New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/46mJrGO

Neue Heisenberg-Professur für die FAU: Prof. Dr. Ruth Beckervordersandforth wird von der @dfg.de‬ gefördert 👏 Beckervordersandforth untersucht Astrozyten, die die Funktion von Nervenzellen im Gehirn unterstützen und regulieren. Mehr über ihre Forschung erfahren: www.fau.de/2025/09/news...

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

Three amazing days of the #neurogen2025 conference at @humantechnopole.bsky.social in Milan. Many thanks to all the participants, speakers and fellow co-organizers. We heard fantastic talks in #neurodevelopment #brainevolution #cancerneuroscience #neuroimmunology #neurodegeneration #neurodiversity

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Excellent work from @silvianeuro.bsky.social lab, led by a brilliant young scholar, @mveronicapravata.bsky.social, on the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors (Nice to see work going beyond the cortex) 🧪🧠🧬🧫

Latest publication from the lab just out in @dev-journal.bsky.social. Find out what happens to the cerebral cortex when depleted from Cajal-Retzius cells... doi.org/10.1242/dev.... Congrats to all authors, and special thanks to Vicente Elorriaga, Benoit Bouloudi and Nathalie Spassky

Regional differences in progenitor metabolism shape brain growth during development: Cell www.cell.com/cell/fulltex...

Exploring human brain development and disease using assembloids: Neuron www.cell.com/neuron/fullt...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

This detailed volume explores techniques for the study of neurogenic niches and neural lineage progression, specifically addressing major methodological challenges in studying neural stem cells (NSCs) and related cell populations, such as astrocytes, oligodendrocytes, and neurons.

...excited to be back home ☺️

Aging activates escape of the silent X chromosome in the female mouse hippocampus | Science Advances www.science.org/doi/10.1126/...

Three fantastic @science.org papers on convergent development & evolution of neurons + their connections in the bird & mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno. Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids | Science Advances www.science.org/doi/10.1126/...

Why do people still use the term "Malformations of Cortical Development" (MCD)? A malformation is a developmental process, there is no need for redundancy; development cannot be malformed. "Cortical Malformations" (CM) alone does the job. Just like the gulf of Mexico is the gulf of Mexico.

The new edition of European Conference on Comparative Neurobiology, ECCN2025 will take place from May 6th to 8th in beautiful Alicante (Spain) and soon you will be able to register and submit your abstracts through the conference website: eccn2025.umh.es

New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵] 🧪🧠🧫🧬

Happy to share some good news today, and our latest study on DDX3X! Led by super talented @federicamosti.bsky.social we use live imaging, transcriptomics and interaction studies to define how clinically diverse missense mutations in DDX3X influence neural development. dx.plos.org/10.1371/jour...

Interested in using functional genomics to understand the brain in health and disease? Check out our Gordon research conference below! Slots for posters and short talks are still available! Deadline March 9th www.grc.org/functional-g...

Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...

So excited to share our new @natureportfolio.bsky.social review on modeling human brain development using organoids! 🧠 Loved collaborating with the brilliant @lancasterlab.bsky.social , led by the incredible @marcellabirtele.bsky.social Check it out! 🔬 #Neuroscience #BrainOrganoids rdcu.be/d3llp

The CSHL conference on neural stem cell models & development coincides this year with the publication of a consortium effort in Nature. This article outlines a framework for experiments with #organoids, #assembloids from QC of pluripotent stem cells to characterizing cells in vitro & in vivo.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Great work from @sergiuppasca.bsky.social’s lab (study led by N. Amin & K. Kelley), producing neural diversity with a multiplexed morphogen screen in organoids (I particularly liked the section on Purkinje neurons, but that’s my cerebellum bias. The whole study is great) www.cell.com/cell-stem-ce...

New Publication 📑 A team led by Silvia Cappello shows how developing #brain #cells communicate with each other through #extracellular #vesicles & that the #protein composition changes during brain #development and varies among different #cell #populations. Read more ➡ www.lmu.de/en/newsroom/...

🧠 Neural stem cell-derived extracellular vesicles (EVs) show promise in tackling neurodegenerative diseases by boosting brain plasticity and repair. Unlike full stem cell transplants, EVs offer targeted, immune-friendly benefits. 🧬 #Neuroscience #BrainHealth #EVtherapy doi.org/10.1093/stmc...

Excited our Large Extracellular Vesicles/Midbody Remnants generated during the cell cycle is out! #ev #mbrs #extracellularvesicles #cellcycle #mitosis www.molbiolcell.org/doi/10.1091/...

Very interesting brain organoid study from Michèle Studer’s lab (study led by M. Bertacchi), demonstrating the key role of FGF8 in regional patterning 🧠🧫🧪🧬 elifesciences.org/digests/9809...

We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social

My first paper as lead author as a postdoc is out on bioRxiv! We show how CSTB influences ganglionic eminence development via intrinsic and extrinsic mechanisms. Huge thanks to @rossdg.bsky.social, Silvia Cappello, and the team for their collaboration on this exciting work!

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

Now in Nature! As a highly collaborative team with people from the Treutlein lab, @fabiantheis.bsky.social and @graycamplab.bsky.social, led by me, @le-and-er.bsky.social and @josch1.bsky.social, we generated the so far largest cell atlas of neural #organoid. www.nature.com/articles/s41...

Last preparations for what will be an amazing CSHL conference on human #brain development and modeling with #organoids #assembloids and #transplantation Keynotes: Carla Shatz & Chris Walsh @djabaudon.bsky.social @debbysilver.bsky.social @vanderhaeghenp2.bsky.social @graycamplab.bsky.social

🗓️ Mark your calendar: May 19-21, 2025 There will be a great #neurogenomics conference @humantechnopole.bsky.social in Milan (@harschnitz.bsky.social ‬ is one of the organizers). Grateful to have been invited alongside (some joined 🦋 recently): @silvianeuro.bsky.social @sergiuppasca.bsky.social 1/