Giorgia Quadrato (@giorgiaquadrato.bsky.social)

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic backgrounds, Stadtfeld and colleagues show that genetic variation is a major driver of epigenome stability and identify candidate regulators. These findings will enable novel approaches to stabilize the epigenome of pluripotent cells in culture. https://www.cell.com/stem-cell-reports/fulltext/S2213-6711%2825%2900054-2