Why do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...

We had a great experience publishing in Development (doi.org/10.1242/dev....). High-quality reviews, quick turnaround, and our editor (Jim Wells) was very helpful and provided feedback about the reviewers comments.

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg

NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-... Know of a relevant event that’s missing? Please reply below

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1

Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

One of the best reviews I read this year...

Hi all! We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids. www.biorxiv.org/content/10.6... #3DGenome #chromatin #Cohesin #centromere

Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)

Nice preview of our paper by Hanwen Yu and Yan Liu. Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...

I know Americans overly romanticize Europe but I still think moving to a little house on a canal in the Netherlands could solve like 82% of my problems

NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US: Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar

📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social! Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV

Redundancy masks functional specificity of SMARCD paralogs in neurodevelopment https://www.biorxiv.org/content/10.64898/2025.12.05.692564v1

TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque: "This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".

Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...

We are excited to share our new preprint: SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids. www.biorxiv.org/content/10.64898/2025.12.01.691499v1

High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/

Last bit of fall still hanging on in Central Park

Don't miss this episode! Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment. Check it out: https://bit.ly/48dmghX

Now live, and thanks to @erictopol.bsky.social for organising this!

New work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants. www.nature.com/articles/s41...

Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium https://www.biorxiv.org/content/10.1101/2025.11.18.689013v1

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

The link between the gut #microbiome and autism is not backed by science, researchers say. Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA#microbiome @wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social

There’s a terrific review of CRICK in @science.org tonight, thanks to @adrianwoolfson.bsky.social. The PDF isn’t working right now; I’ll post a screenshot later. Here’s the paywalled html link:

We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉 Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds https://www.biorxiv.org/content/10.1101/2025.11.08.687374v1

In the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics Listen here: www.activemotif.com/podcasts-rya...

Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...

Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...

Wow... www.statnews.com/2025/11/04/a...

Oocyte-like mouse cells made from stem cells even without the guiding signals from ovarian cells. Another step towards in vitro gametes. www.cell.com/developmenta...

tepid take: a lotttttt of job postings for bio-AI researchers, not enough job postings for generating-the-extremely-necessary-data-for-bio-AI researchers

The Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!

Post-translational Tuning of Human Cortical Progenitor Neuronal Output https://www.biorxiv.org/content/10.1101/2025.10.27.684791v1

Talk about an in-flight meal. For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn

Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast https://www.biorxiv.org/content/10.1101/2025.10.27.683165v1

For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease. But the mouse reference genomes still have missing pieces. The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains. 🧬💻

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1

What a cool paper. Also note that this very careful analysis does not support the majority of synonymous variants being non-neutral in yeast

🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵

Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice https://www.biorxiv.org/content/10.1101/2025.10.16.682851v1

Xenopus embryo growth cones move at 100-120 µm/hour 🏎️ doi.org/10.1083/jcb.... Scale bar below if 10 µm and total time is 11 minutes.That's about 2 times the speed of the fastest cell in the 2013 Cell Race! (doi.org/10.1016/j.cu...)

Very exciting announcement from @plasmidsaurus.bsky.social Bye Bye forever qRT-PCR!! plasmidsaurus.com/rna