Why do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...

Read about our recent paper here: www.bdi.ox.ac.uk/news/first-d...

✨ NEW PUBLICATION ✨ We combined large-scale human genetics with CRISPR-Cas9 editing in fat cells to identify genes linked to fat accumulation. Check out the full study, now published in AJHG! www.cell.com/ajhg/fulltex...

Check out this PhD opportunity to work with a great supervisor at Oxford! 🌟

So excited to give a talk at #ESHG2025! ✨ I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants. This has implications for: - Screening of rare disorders 🔎 - Target discovery 💊 - Improving trait prediction 📈