Hey Chromatin Friends! Long time no chromatin question... For many of you, CUT&x (RUN/Tag) works really well but some of you have had their frustrations with CUT and "gone back" to ChIP-Seq. Can you share your experiences in the comments!? Would love to hear from you! Sharing is appreciated : )

Ramsey Najm and I have a joint postdoc position advertised through the @hlsalliance.bsky.social Interinstitutional Postdoc call! Our project proposes to generate better posterior cerebellar organoids to improve fidelity of pediatric medulloblastoma models. www.health-life-sciences.de/opportunitie...

Esther Becker, Simone Mayer and @lenakutscher.bsky.social teamed up to summarise current approaches for generating #cerebellar #organoids and advocate for the establishment of rigorous quality control standards to ensure reproducible, high-quality research. Read doi.org/10.1242/dmm....

Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...

Some friends and I wrote a review with @biologists.bsky.social !! Together with Esther Becker and Simone Mayer, we explore the state of the cerebellum organoid field and offer practical guidance on getting this model system started in your own lab. journals.biologists.com/dmm/article/...

From my work on gerrymandering, I know that New Jersey politicians play dirty. Now my campaign faces its first test. To beat their petty games, I need at least 1,000 signatures from Democrats and unaffiliated voters in the 12th District. It's cold work. To help, sign up at SamForNJ.org - or DM me!

News from central Jersey: I'm running to represent New Jersey's 12th Congressional District. By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come! samwang.substack.com/p/entering-t...

I've started my own lab 🎉 PhD/postdoc positions available - reach out if curious about cerebellum evo-devo and autism spectrum disorders. We’re based at Uni Tartu, Institute of Genomics (home to Estonian Biobank), and funded by @simonsfoundation.org @embo.org, and the Estonian Research Council.

Today I made a small but momentous start to work in 2026 by changing a single number. I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”. Stay tuned for more file updates on 1st January 2027.

I love this live version of the new @themountaingoats.bsky.social song. 🎶"There's always a clock ticking somewhere."🎶 youtu.be/pv53gRqjvxY?...

This entire weekend

The @dkfz.bsky.social PhD Program is open, and the Mall Lab is recruiting PhD students. 1: in vivo and organoid models to study and treat autism associated disorders. 2: cancer cell plasticity in brain tumors using single cell genomics and perturbation screens. Apply now: www.dkfz.de/en/career/in...

This will be a very exciting meeting! Looking forward to see you there Please spread the word

Olya Yarychkivska of @rockefeller.edu will kick off the #SDBPostdocSeminar with her talk "Myelin regulatory factor 1, identified by single cell transcriptomics, primes a migrating cell for non-apoptotic cell death" Image: Linker cell at the tail of a C. elegans male

Emmy Noether grant for DKFZ researcher Jens Puschhof.👏 With this grant, he aims to decipher the role certain intestinal bacteria play in the earliest stages of colon cancer development and how this process can be halted. t1p.de/aoeve @jenspuschhof.bsky.social

Paracetamol remains an important option to treat pain or fever in pregnant women. Following rigorous assessment of the available scientific data, we find no evidence that taking paracetamol during pregnancy causes autism in children. Read more 👉 www.ema.europa.eu/en/news/use-...

I am more than thrilled to announce that I will be starting my own lab at the Neuroscience Department at MUSC in November 2025! We will be studying the origin of pediatric brain cancers through the lens of brain development! My lab is hiring see here: cschmidtlab.xn--com-gr63bea

Like our sister journals, you can also submit an additional language abstract at @dev-journal.bsky.social and we cater for non-Western characters for author names. Did you know Development also facilitates retrospective author name changes?

🧠 Position still opened! Don't hesitate to apply if you want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders!

The mid-decade redistricting wars are unending. I'll be on CNN with Jake Tapper to talk about what we know and what it means. Is democracy dead? Is there hope? What can citizens do? This Wednesday August 13, sometime around 5:00-7:00pm Eastern. Precise time when I know it.

While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...

i love my job #fluorescencethursday

We’re hiring! Come join our group at the DKFZ in Heidelberg. We’re seeking a MSc or PhD level bioinformatician who enjoys working in a team! Would be grateful for you to share with your networks. jobs.dkfz.de/en/jobs/1678...

Serious FOMO that I can't attend #Worm25

Did the miss the Cerebellum Development and Disease conference last year? Never fear, as we wrote up a conference report! link.springer.com/article/10.1...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

In response to someone in our running WhatsApp saying they were the slowest in the group, somebody replied, “Comparison is the thief of joy…” I’m going to think about that for the rest of the day

There’s been some “advice” coming from some quarters for scientists not to focus on DEI-related funding cuts. I wholly reject this concept. Cutting programs designed to reduce science and healthcare disparities is as detrimental to science as anything else, both morally and functionally.

Big congrats to our longtime collaborators in the Stefan Pfister and @lenakutscher.bsky.social labs — large-scale chromosomal changes as early tumour-initiating events in Group 3/4 medulloblastoma!

new out in Nature www.nature.com/articles/s41...

important reminder for people getting into arguments with people who are wrong in my mentions

Yes. This is an absolute crisis—and not a subtle one. Thread:

MSK's Dr. Alexandra Joyner is hanging up her lab coat following an illustrious 40-plus-year career. When asked what advice she has for new scientists, she shares: "You have to decide: Why are you going into this career? And then you have to stay true to that." Learn more about her legacy & impact ⬇️

Deadline extended! 🌟 Join us at the Neurogenomics Conference! 🧠 Dive into cutting-edge research on neurodevelopment, brain evolution, neurodegeneration, and more. Submit your abstract & register by 14 April 👉 humantechnopole.it/en/trainings...

"we have been watching with growing concern policy changes in the US...The scale of disruption to science is unprecedented...We are concerned with policies that threaten censorship & removal of public data...To our colleagues in the US, we stand with you" journals.biologists.com/jcs/article/...

🔬✨ Be a part of #EANO2025! Submit your abstract now and present your research as an oral presentation or poster at the big event in Prague. We can't wait to see your contributions! Click here for more information: www.eano.eu/eano2025/abs... #NeuroOncology #neurosurgery #cancernurse

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org a 🧵

Carolinians - this Thursday 3/27, join NC Supreme Court Justices Anita Earls and Allison Riggs and me for a panel discussion about voting rights in North Carolina. Doors open at 5:30 pm and the discussion begins at 6 pm at The Varsity Theatre on Franklin Street, Chapel Hill.

Developmental biology research leads to fundamental discoveries for biomedical research. Apoptosis. Ellis & Hovitz, 1986. PMID: 3955651. Worm image by Tokiko Furuta (Arur Lab) @socdevbio.bsky.social 9/12

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025

Rita Levi-Montalcini defied fascism, which excluded her from university due to her jewish ancestry, by setting up a clandestine lab in her own bedroom. During 1940-42 she carried out experiments that set the foundations for her Nobel-prize-winning research a decade later. nautil.us/a-lab-of-her...

Lab surprised me with a gift celebrating 5-years of the Kutscher Lab. Couldn’t imagine a better group! Excited for the next 5 years! 🫶🫶

#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology

Each piece of good news no matter how small is like a knife of light and we will need many to cut through this shroud. There I no question we will need a concerted effort to help our colleagues who find themselves in a terrible situation through no fault of their own. But we can do both. /2

Happy Valentine’s #fluorescentfriDay photo cred by postdoc Dr. Patricia Benites

Big news - I'm going to be moving to a new position at The Company of Biologists, working across all our journals. This means my job is up for grabs! If you're an experienced editor with a love of developmental biology and its community, this could be the role for you. Full details in the link.

Join the International Heidelberg Organoid Meeting 2025 🧠🫀🫁🔬March 20-21 @ Marsilius-Kolleg #Heidelberg! With exciting keynotes and abstract-selected posters & talks, iHOME will cover #cancer #organoid research from basic to clinical. Limited spots; register now: indico.dkfz.de/event/1249/