🏳️‍🌈 #PrideMonth: we're highlighting research led by ERC grantee Kath Browne @ucddublin.bsky.social, exploring perspectives on social change around sexual and gender rights, with a focus on understanding polarisation and fostering dialogue. 🎥 @kathbrowne.bsky.social

Very insipring work from Magdalena Gotz lab - Nuclear proteome reveals microtubule-associated protein regulating fate and disease: Cell www.cell.com/cell/fulltex...

I am thrilled to announce I’ve been awarded a DFG Emmy Noether grant to establish the Pravata Lab at FAU! 🎉🔬 We'll explore how glycosylation shapes human brain development & evolution using neural organoids. And... we are hiring! 🧵👇 @dfg.de @fau.de

Thrilled to shared our new preprint with @djabaudon.bsky.social ! Led by Ilaria Morassut, we explored "the extent to which early brain maturation requires interactions with the outside world". This wouldn't have been possible without our incredible collaborators, specially the @lanevol.bsky.social 🧵

“Comparative analysis of the cellular landscape in mammalian striatum” Very valuable resource, by @konopkalab.bsky.social @sonjavernes.bsky.social and collaborators (interesting specificity observed in bats and key primate/non-primate differences) 🧪🧠🧬 www.nature.com/articles/s41...

Glycan Atlassing is online at @natnano.nature.com! Thanks to everyone involved, especially to @dijo-mj.bsky.social and @nazlicanyurekli.bsky.social who spearheaded the work. Read the paper here: dlvr.it/TSXNDb #Glycotime

Great paper on developmental gene expression patterns underlying species-specific cortical features (with a nice combination of tools and datasets) By @itsmeawais.bsky.social @estherkli.bsky.social @djabaudon.bsky.social @silvianeuro.bsky.social @mveronicapravata.bsky.social and colleagues 🧪🧠🧬

The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...

There are transient interactions between cellular elements in the developing brain. Proteomic data generation is now essential for ligand–receptor pair prediction & validation. We examined brain regions, of a single human 20GW brain from @HDBR, Univ Newcastle. onlinelibrary.wiley.com/doi/full/10....

Who “belongs” in biology? The first comprehensive analysis of the LGBTQ+ climate in the biological sciences! #LGBTinSTEM #preprint 🏳️‍🌈 #preLight prepared by @ryanharrison13.bsky.social, Stefan & @reinierprosee.bsky.social ⬇️👀 prelights.biologists.com/highlights/l...

📢 We are pleased to announce our 4th open science summer school! #OSSS25 📌 Sept 15-19, Munich & Zoom 🔥 keynotes and outstanding hands-on workshops 2️⃣ dual-track: open science training and instructor training tracks! ➡️ apply before July 14 or register anytime for the public lectures!

Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...

Still openings, check it out!

Very cool @natgenet.nature.com study by @danielibrahim.bsky.social revealing hidden enhancer conservation across distant species via genome synteny 🧪🧬 Nice overview by @alexdemendoza.bsky.social: www.nature.com/articles/s41...

Check out this superb, beautiful and insightful work from @silvianeuro.bsky.social lab led by my brilliant colleague @mveronicapravata.bsky.social! What a thrill to learn about key biochemical changes across evolution contributing to drive brain formation😊 www.biorxiv.org/content/10.1...

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Excellent work from @silvianeuro.bsky.social lab on DCHS1 ! @mveronicapravata.bsky.social congratulations! www.biorxiv.org/content/10.1...

Excellent work from @silvianeuro.bsky.social lab, led by a brilliant young scholar, @mveronicapravata.bsky.social, on the impact of a mutation in DCHS1 distinguishing sapiens from Neandertals: shifting the ratio between cortical & striatal progenitors (Nice to see work going beyond the cortex) 🧪🧠🧬🧫

Delighted to share our new preprint, the outcome of many years of collaborative work with Giuseppe Testa’s group, both at the bench & in front of the computer, probing human brain evolution using organoids. We tried something cool, and learned a lot 🧪🧫🧠🧬 [follow 🧵] www.biorxiv.org/content/10.1...

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation

Brilliant new preprint by @ioansarr.bsky.social @marisepp.bsky.social @tyamadat.bsky.social @steinaerts.bsky.social @kaessmannlab.bsky.social on the evolution of gene regulation in mammalian #cerebellum development 🧪🧠🧬 www.biorxiv.org/content/10.1...

Amazing Lab, fantastic people and a stellar PI: Klingler Lab is a wonderful place for a great postdoc!!

Open positions in human developmental neuroscience, check it out!

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

☕️Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human #pluripotent stem cells by interacting with #NuclearMatrix protein, Matrin-3, and regulating primed-specific genes. 👉https://rdcu.be/ebq0W bit.ly/4iiVHLV

I often see misunderstandings & confusion (in media but also scientific literature) over what studies of the FOXP2 gene can & cannot tell us about human evolution. Here's a short commentary I wrote a few years ago for @currentbiology.bsky.social with aim of clarifying for a general readership. 🧬🗣️🧪

Beautiful new work by @itsmeawais.bsky.social @estherkli.bsky.social @djabaudon.bsky.social @silvianeuro.bsky.social @mveronicapravata.bsky.social & L. Gomez, probing evolutionary changes in the developmental expression of shared genes, focusing on the cortex. Key role for JUNB in human 🧠 👇🧬🧫🧪

🚀 Excited to share our latest work uncovering TGIF2 as a key transcription factor (TF) safeguarding neural stem cell (NSC) fate and regulating neurogenic priming! 🧠 🔗 biorxiv.org/content/10.1101/2025.02.13.635953v1 Here’s how we found it and why it’s important!🧵👇

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...

Three fantastic @science.org papers on convergent development & evolution of neurons + their connections in the bird & mammalian pallia, by @kaessmannlab.bsky.social @steinaerts.bsky.social & Fernando García-Moreno. Expertly synthesised by @giacomogattoni.bsky.social & Maria Antonietta Tosches 🧪🧠

Our new paper is out in BioRxiv. Using human fetal tissue and cortical organoids, we figured out how human bRG cells colonize the developing neocortex to expand the oSVZ stem cell niche. Turns out, it's a more complex process than we had anticipated! www.biorxiv.org/content/10.1...

Our International Max Planck Research School is offering two PhD fellowships, funded by @maxplanck.de & hosted at @mpi-nl.bsky.social, to carry out innovative research projects on language & genetics, & on multimodal language. Application portal closes 6th Jan 2025! 🧪 www.mpi.nl/imprs-phd-fe...

🌟 Whether you’re a new student, lab leader or decision-maker at an institutional level, you can now find free tools and guidance all in one place. Our Learning Resources page launched in October thanks to insights from eLife Ambassadors. #12DaysOfeLife https://buff.ly/4f8vIpk

After an inspiring visit to MPI-EVA (thanks Genevieve Housman!), I’ve been re-reading one of my favorites, Neanderthal Man. If you’re a young student considering PhD, read Chapter 2. If you’re a PhD student feeling a bit lost in your project, read Chapter 2. If you're...., read Chapter 2 anyway

The CSHL conference on neural stem cell models & development coincides this year with the publication of a consortium effort in Nature. This article outlines a framework for experiments with #organoids, #assembloids from QC of pluripotent stem cells to characterizing cells in vitro & in vivo.

I wrote some thoughts about why peer review matters It shapes scientific standards, maintains field coherence & trains new researchers Yes, it needs improvement—but it's the glue that holds scientific progress together briscoelab.org/2024/12/11/i...

Excellent perspective from @sergiuppasca.bsky.social, Paola Arlotta, @silvianeuro.bsky.social, @studerl.bsky.social & others on the need to improve experimental design & carefully characterise hPSC quality to improve the reproducibility of organoid & assembloid models. www.nature.com/articles/s41...

Excited to attend the Development & 3D Modeling of the Human Brain with the support of a #DMMgrants Conference Travel Grant! Grateful to @dmmjournal.bsky.social for this opportunity to present and connect! If you are into Evo-Devo, pass by poster 154 on Wednesday! #DMMConference #cshl2024brain

Terrific summary and forward looking overview by Georgia Panagiotakos and Nan Yang of our recent work in Cell Stem Cell to generate large cell diversity in neural #organoids using outcome-agnostic screening approaches www.cell.com/cell-stem-ce...

‼️Job alert ‼️(please share) The lab is slowly growing 😃 I'm looking for a postdoctoral fellow in computational biology👇 Please get in touch if interested in the position!!

My first paper as lead author as a postdoc is out on bioRxiv! We show how CSTB influences ganglionic eminence development via intrinsic and extrinsic mechanisms. Huge thanks to @rossdg.bsky.social, Silvia Cappello, and the team for their collaboration on this exciting work!

🚨 Come work with us, we’re hiring! 🚨 See below our 2 postdoc positions at @institutpasteur.bsky.social in Paris. Funded by our ERC Synergy grant, this is a collaboration with the labs of Víctor Borrell in Spain ( @borrell-lab.bsky.social), Laurent Nguyen in Belgium and Kristian Franze in Germany 🧵⬇️

The integrated transcriptomic cell atlas of human neural #organoids, Barbara Treutlein's lab, @fabiantheis.bsky.social @graycamplab.bsky.social @sergiuppasca.bsky.social @giorgiaquadrato.bsky.social and colleagues: www.nature.com/articles/s41...

We are committed to ethical publishing and are a member of several organisations dedicated to maintaining #PublicationEthics standards. To celebrate #PublicationIntegrityWeek we present some key information regarding our publication integrity work. www.biologists.com/stories/the-...

Interesting study from Igor Adameyko & co developing clonal lineage analysis in mouse embryos Nice analytical method: Adapting word2vec as a way to embed & cluster lineages on the basis of their cell type composition www.biorxiv.org/content/10.1...

🚨 We’re hiring! 🚨 We're looking for a postdoc for our ERC Synergy project Unfold (unfold-lab.github.io). Join our lab at @institutpasteur to model brain morphogenesis! (1/10)

We have a few more spots on this #bluesky starter. Who else should we include? Please suggest #brain #development #neurodevelopment go.bsky.app/SxcKi5z