No, Tylenol does not cause autism. And there is no compelling evidence that leucovorin reduces symptoms. A consensus summary is found here - www.coalitionofautismscientists.org

Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra www.biorxiv.org/content/10.1...

New #cilia preprint alert Our latest manuscript is now live on bioRxiv: "The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity" We hope you enjoy reading it! www.biorxiv.org/content/10.1...

New preprint alert! Excited to share our latest study, now live on bioRxiv: "The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress" www.biorxiv.org/content/10.1...

Detailed characterization of the recurrent, independent evolution of a medically relevant locus across humans and great apes — the 17q21.31 locus By @psudmant.bsky.social and colleagues 🧪🧬 www.biorxiv.org/content/10.1...

🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders! We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social 📅 Event date: September 19, 2025 📍 Location: Erasmus MC Rotterdam 🔗 Register now: www.neurodevdisorders.org

It was a pleasure of having @cedricboeckx.bsky.social visiting us on his way to the Max Planck in Nijmegen. He even wanted to help @ellylewerissa.bsky.social in the lab. Look at her reaction.

What an incredible week at the GRC on Excitatory Synapses! Thrilled for the chance to share our work on building an all-human co-culture of excitatory and inhibitory neurons, astrocytes and microglia to better capture synapse biology in health and disease. A huge team effort driving this forward!

If you are at the GRC on excitatory synapses @nickyscheefhals.bsky.social will be presenting on Wednesday.

🎥 MAP2 (green), PSD95 (magenta), inhibitory neuron (blue) @naelnadifkasri-lab.bsky.social lab

New paper alert! How many neurodevelopment disorders would be amenable for ASO treatment? Fabulous PhD student @Kim Wijnant, did the analysis. genomemedicine.biomedcentral.com/articles/10....

Bart De Strooper giving The EMBO Keynote Lecture - From correlation to mechanisms: how genetics determine your risk of Alzheimer’s disease at #neurogen25 @nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social @r3rt0.bsky.social

Nael Nadif Kasri @naelnadifkasri-lab.bsky.social exploring the role of the primary cilium in neuronal plasticity and development: How the quiet organelle claims center stage! at #neurogen25 @nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social @r3rt0.bsky.social

RIP #JanTerlouw. Zijn boeken leerden me lezen, dromen en denken. Dank je wel, Jan.

Bonus result: the lysosome/autophagy pathway surfaced as an important dimension of maturational tempo, in line with our recent work with @naelnadifkasri-lab.bsky.social (study led by @olivieroleonardi.bsky.social & @ellylewerissa.bsky.social) www.biorxiv.org/content/10.1...

New paper alert! We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense oligonucleotide therapy. Kudos to PhD student Kim Wijnant www.biorxiv.org/content/10.1...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...

New paper alert on Inter-individual variation in fusion transcript expression representing an overlooked source of genetic diversity #evolution #disease www.biorxiv.org/content/10.1...

Interested in disease modelling, stem cell models metabolism and novel on-chip technology? Then this might be an exciting project for you. PhD position in now open www.radboudumc.nl/en/vacancies...

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...

Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social

Loved this lab coat that I spotted in Raleigh

Science matters! Supporting all my colleagues around the world and especially in the US. Let's hope for a great turnout today. #standupforscience2025

📣 Science matters! #FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬 🔗 Read the full statement: loom.ly/cn7vJR4 #sciencematters #standupforscience #sciencenotsilence #scienceforall

Great opportunity for students in the EU to attend summer school with stipend!

📢 Final call for stipends for our stem cell summer course on neurological disease modeling. Deadline: ‼️ March 05 2025 ‼️ Students studying in the EU (but not in the Netherlands) can apply here: loom.ly/yJqQ0rY

If you are interested in disease modelling using state of the art stem cell based approaches, consider joining us during the summer school. fellowships are available!

Nice work by my former colleague Franck Oury, on a new function for osteocalcin in the primary cilia! www.nature.com/articles/s43...

haha loving Danish humor denmarkification.com

It's #DarwinDay, the year 2025. And (sad to say) this insight from the 1870s is more relevant than ever.

Interested in neuronal disease modelling? Consider joining our summer school in July. It will be fun👇

Super excited to share this study.

It’s a privilege to announce Solve-RD’s latest manuscript based on years of work: “Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses” www.nature.com/articles/s41... A thread (1/n)

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

A quantitative spatial atlas of transcriptomic, morphological, and electrophysiological cell type densities in the mouse brain https://www.biorxiv.org/content/10.1101/2024.12.30.630728v1

Just bumping this up for those who may have missed earlier announcements-- we have a new PI position in the Neuroscience & Mental Health program here at SickKids. Neural and glial mechanisms in cognition.

Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human https://www.biorxiv.org/content/10.1101/2024.12.21.629881v1

Scala naturae thinking is alive and well! It turns out that the brain of humans is different from that of other species, could not have guessed that... Ah, also in the "correct order"... From: www.nature.com/immersive/d4... #neuroscience

Wishing everyone a lovely holiday season. Warm MEA- Xmas greetings from the lab!

#Organoid puzzle done!

PhD Job alert! If you are interested in #metabolism, neuronal function, #ipsc and Chip technology, consider applying for this position. www.radboudumc.nl/en/vacancies...

More on the timing of neanderthal/sapiens admixture www.nature.com/articles/d41...

Very interesting functional precision medicine study: glioblastoma patient-derived organoids treated with dual-targeting EGFR-IL13Rα2 CAR-Ts mirrored clinical parameters www.cell.com/cell-stem-ce...

Cilia take center stage in neurodevelopmental disorders. I think this is only the beginning, many more studies to follow. Stay tuned #cilia www.biorxiv.org/content/10.1...

Also check out the rest of the #HumanCellAtlas paper collection including insightful perspective articles: nature.com/collections/... @natureportfolio.bsky.social

🗓️ Mark your calendar: May 19-21, 2025 There will be a great #neurogenomics conference @humantechnopole.bsky.social in Milan (@harschnitz.bsky.social ‬ is one of the organizers). Grateful to have been invited alongside (some joined 🦋 recently): @silvianeuro.bsky.social @sergiuppasca.bsky.social 1/

Great to know these online tools are available for making cartoons! bioart.niaid.nih.gov bioicons.com scidraw.io

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

Last preparations for what will be an amazing CSHL conference on human #brain development and modeling with #organoids #assembloids and #transplantation Keynotes: Carla Shatz & Chris Walsh @djabaudon.bsky.social @debbysilver.bsky.social @vanderhaeghenp2.bsky.social @graycamplab.bsky.social