These rankings are kinda silly… but hey, we’re #1 🍾🥂🥳

Form follows function, or function dictates form? 📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible grad student Boli Wu! www.biorxiv.org/content/10.6...

Xin Jin FTW! "We developed Perturb-CLEAR, which integrates pooled CRISPR screening and whole-mount imaging to quantify brain-wide cytoarchitecture, and paired it with Perturb-seq to link structural phenotypes to transcriptomic changes." www.biorxiv.org/content/10.6...

Thrilled to announce Critical Mass Ventures, a philanthropic initiative bridging science, capital, and community to close the gap between lifespan and healthspan. Our inaugural postdoc fellowship is now open. 🔬 criticalmassventures.co #ScienceSky #AcademicSky #Healthspan #Longevity #Postdoc

“Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq” Truly impressive work by @xinjin.bsky.social 🤯🧪🧬🧠 www.biorxiv.org/content/10.6...

Excited to introduce @perturb.ai, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics www.perturb.ai/news

Excited to share: enhanced capture in vivo multiome Perturb-seq! Worried about low gRNA recovery and wasting sequencing on cells that can’t assign a perturbation? We engineered gRNA transcripts to stay in the nucleus, enabling efficient multiomic Perturb-seq! www.biorxiv.org/content/10.6...

Assoc. Prof. @xinjin.bsky.social has been named a 2026 Sloan Research Fellow by the @sloanfoundation.bsky.social, recognized for pioneering in vivo Perturb-seq—a gene-editing approach combining CRISPR technology and single-cell RNA analysis to uncover how genetic variation shapes brain development.

It was such an amazing visit at Utah Neuroscience! I learn from such a diverse crowd of neuroscientists doing super cutting edge works in many fields - and their trainees who are engaging and thoughtful. Campus view is unbelievable! Thank you @jasonsynaptic.bsky.social for having me!

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.

Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond. Free registration link: www.eventbrite.com/e/dorris-neu...

Actively hiring! Video made by Sora-2 but the job post is 100% real. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

First time bringing my fantastic students to the HHMI Science Meeting and they absolutely shined at the session! ✨ It remains one of the most stimulating mtg — I’m science-starstruck every 10 min. We’re grateful for the chance to spark new collaborations that will take our technologies further

We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Terence Tao (@teorth.bsky.social) has written a thread on Mastodon about the impact of the federal grant freeze to UCLA, particularly to his own field of Mathematics. UCLA's IPAM (Institute of Pure and Applied Mathematics) could shut down entirely mathstodon.xyz/@tao/1149568...

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

BIG NEWS: “Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.” Thank you to members of the Senate Appropriations Committee on both sides of the aisle! www.axios.com/pro/health-c...

Science and innovation drive every breakthrough. On 7/21, a nation-wide campaign kicks off to honor Apollo 11’s legacy -- tell Congress NO to research‑funding cuts. Speak up here: ProtectScienceAndInnovation.org #ProtectScience #InnovationMakesAmericaGreat

I don’t think anyone is prepared for what they just did w/ ICE. This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined. It is setting up to make what’s happening now look like child’s play. And people are disappearing.

Working link here! www.biorxiv.org/content/10.1...

Honored to be an HHMI FHS! Grateful to brilliant colleagues who push me to think deeply, and to my students whose curiosity & energy make the lab a joy. My grad advisor said in genetic screens, you don’t get what you want—you get what you deserve. Hope we are deserving www.hhmi.org/programs/fre...

Congratulations to the 2025 McKnight cohort!

Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!

Love seeing friends and colleagues #slay! Congrats to @moriel-z.bsky.social @utah.edu for becoming a @hhmi.org Hrabowski scholar! Also congrats to @tinakim-neuro.bsky.social @xinjin.bsky.social @doctheagrif.bsky.social www.hhmi.org/programs/fre...

Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1 www.cell.com/cell-reports...

KODAMA goes spatial. doi.org/10.1101/2025... #spatialtranscriptomics #visium #visiumhd #seurat #giotto

It was fantastic to share some unpublished work with the Klingenstein family, especially on the same panel with my friend @justuskebschull.bsky.social! Grateful for the opportunity and inspiring talks all around from our cohort

The bipartisan framing of Chinese people as dangerous to the United States has been building up for years and has created this deeply racist and xenophobic opening for the Trump administration. I stand with my Chinese colleagues and all of our Chinese students. 🧪

This administration is so stupid.

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord. This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators. 🧠📈 www.nih.gov/news-events/...

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Great article by @nobelprize.bsky.social laureate @ardemp.bskyverified.social outlining the health, economic and national security benefits of US biomedical research, and the devastation of government efforts to destroy our leading edge. www.cnn.com/2025/04/09/h...

Thrilled to share 2 reviews from the lab: 🧬Annual Review Functional Neurogenomics annualreviews.org/content/jour... 🧠Current Opinion high-throughput analysis of corticogenesis authors.elsevier.com/sd/article/S... Thanks to my labbies and the field—we were honored to showcase your work! #WeAreHiring

Another scoop from Jeff Mervis (@policyhound.bsky.social): NSF's ~1400 grant terminations have disproportionately affected PIs from groups underrepresented in science: women, racial & ethnic minorities, & those with disabilities. 1/3 www.science.org/content/arti...

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Science has its highs, lows, low-before-highs, and occassionally ‘cowboy hat + champagne’ plot twists. Not every day is easy, but some are downright legendary. Grateful for the laughs -- with colleagues that I adore

The current administration’s narrative that Harvard (and all universities) feel “entitled” to federal dollars misleads the public. Nor are these funds a “privilege” 1/n

EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...

A few of us at Scripps had the pleasure of having dinner with the amazing @dulaclab.bsky.social after the first of two Kuffler lectures at UCSD! Great company with Lisa Stowers, @antihebbiann.bsky.social, and @xinjin.bsky.social

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

We are hearing that there is a meeting of all NIH IC directors happening now. We are also hearing, from several sources, rumors about director and assistant director level removals coming soon. The impact of this wld be enormous. IC directors have all grantmaking authority for each institute. 🧪

Despite the trying times, thrilled to share our @natprot.bsky.social Nature Protocols on massively parallel in vivo Perturb-seq: www.nature.com/articles/s41... Grateful for the excellent primer by Christopher Bock and Eugenia Pankevich: www.nature.com/articles/s41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

To my friends and colleagues at UAB, IU, UF, FSU, UL, WashU, OSU, CWRU, etc, etc. Call both your senators and your representative. They listen. Emphasize the direct economic impact of NIH research, and the indirect impacts on pharmaceutical/biotech. Underscore its relevance to national security.

Devastating. It's called indirect costs but there’s nothing 'indirect' about it. It covers electricity, HR, payroll, research core facilities: the kind of costs that any business would budget for as essentials. They are everything that keeps science running.

Federal restrictions & funding freezes threaten vital research and halts scientific progress that benefits all Americans. Join fellow #NeuroAdvocates in urging Congress to protect congressionally approved funding & ensure uninterrupted support for the scientific workforce. 👇 #NeuroSky

Dear All, I believe that this thread will become one of my most important contributions to the fly field (I hope I will make other contributions)! Here, I introduce the Soy Milk Machine Fly Food Method, a.k.a., DeepCook!#Drosophila#NewPI