Was a fun & collaborative article to write, hopefully interesting to the reader as well!

Huerta et al. find that standard analgesics reliably reduce spontaneous neuropathic pain in preclinical models, mirroring clinical efficacy and highlighting the value of assessing non-evoked pain. Learn more in #PAIN bit.ly/4hHOvJU

Crisp & sunny start to the day: 🏃🏻‍♂️ = ✅

🚀 NAPS applications open this week! The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec. 📍 Apply Nov 28–Jan 31 👉 northamericanpainschool.com/registration/

Have you heard who the speakers of the distinguished Keynote Prize Lectures will be for #IASP2026? Check out @iasp.bsky.social President Andrew Rice’s announcement on #PRF to find out now bit.ly/47ZGkWt

Have you heard of MDFIC2, the newly identified sensory neuron-enriched modulator of PIEZO channels? Check out Habib et al. in @pnas.org, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/4renN08 ##EditorsPick#PRF

Bleak, blustery, & a little damp, but 🏃🏻‍♂️ = ✅

Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain www.science.org/doi/10.1126/... Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane

Happy #Caturday 😺😺😺

Bit later than anticipated, courtesy of a 4-hour transfer delay in Chicago, not much sleep = not much energy, but Friday short 🏃🏻‍♂️ = ✅

Pretty exciting to develop simpler, faster ways to target specific neuronal subtypes 🤩 I'm looking forward to seeing this be expanded and integrated in future pain studies ☄️ #PainResearch #Neuroscience #DRG #FACS

Great time at @sfn.org meeting, catching up with old friends & making new ones 😊 Great to have got positive feedback on our symposium & @interlukein.bsky.social / @mayadannawi.bsky.social had lots of interest in their posters 😃 ✈️ tomorrow with lots of ideas...just got to get 💷 to support them!

At 13:00 our @phar.cam.ac.uk lab will be live @sfn.org! Poster N3 sees @mayadannawi.bsky.social presenting on overexpression of Prdm12 in the adult sensory nervous system Poster O6 sees @interlukein.bsky.social presenting on loss of Piezo2 in colonic sensory neurons with age Please drop on by 😃

Last San Diego ☀️ 🏃🏻‍♂️ = ✅

Spread the word!! Our amazing EPLS programme is open for applications! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social

San Diego sparkling in the sun & 🏃🏻‍♂️ = ✅

Had a great time at our @sfn.org #PainResearch symposium yesterday, talks covering a whole range of pain states & roles of non-neuronal cells, review article for more reading: www.jneurosci.org/content/45/4... Thanks to @cherylstucky.bsky.social, @mdburton.bsky.social & Anne-Marie Heegaard!

Interesting @sfn.org session kicking off: “What’s in a name? Define the boundaries of neuronal cell types”. Introduced by @vabraira.bsky.social who provided a background on her name, engaging way to emphasise the importance of names. Talks from Jeremy Miller & @tedpricethepainguy.bsky.social

Swapped wet & windy Cambridge for wet & windy (& warmer!) San Diego, which definitely has bigger boats than Cambridge 😅 Pre-symposium warm up 🏃🏻‍♂️ = ✅: if you’re at @sfn.org & want to know more about pain, come along this afternoon 👇

Very wet & windy this morning, & extra early start as 🚕, 🚊, 🚇, ✈️ & San Diego / @sfn.org await, but 🏃🏻‍♂️ = ✅

With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch Here's our accompanying review! www.jneurosci.org/content/45/4...

Wet, windy, & lots of puddle hopping required, but 🏃🏻‍♂️ = ✅

Here's the lineup of #sfn25 artist exhibitors all on one page

Submit your Painhack project for the 2026 World Congress on Pain in Bangkok, Thailand. During the Painhack, interdisciplinary teams will collaborate to develop new ideas and methods to address key challenges in pain research and management. Submission Deadline: 21 November. bit.ly/4nB9tM7

How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science. 🔗 www.sciencedirect.com/science/arti...

Cool & sunny out this morning, great weather for 🏃🏻‍♂️ = ✅

Slow start to this #Caturday 😺😺😺

🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology! Paper: biorxiv.org/content/10.1... Data: humandrg.painseq.com

Misty out round Cambridge this morning: Friday short 🏃🏻‍♂️ = ✅

After some hangups in getting the data available on SPARC, our Nageotte nodule Visium data described in this paper: www.nature.com/articles/s41... is now freely available to download on SPARC: discover.pennsieve.io/datasets/490

To the colon! Acidic buffer virtually FAILED to activate lumbar splanchnic nerves from KO 🐭. a couple of years on from when @LukePaine4 first showed me the data I am still 🤯

Warm out this morning for early November + dead legs = not much fun, but 🏃🏻‍♂️ = ✅

A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...

A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...

Looking rather autumnal, it’s almost 5-years to the day that I collected some acorns from Coldfall Wood, an ancient woodland in the heart of London, & decided to grown some oaks!

Wet & grey start to the day, with jet lag thrown in for fun, but November half marathon 🏃🏻‍♂️ = ✅…should aid circadian reset & help with sleeping tonight 😅

Happy #Caturday 😺😺😺 Great to be back in Cambridge & greeted by these 3!

Friday short 🏃🏻‍♂️ = ✅ & last day in Shanghai, which has been a blast!

Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...

#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch 📖: www.sciencedirect.com/science/arti...

Lovely morning in Shanghai & 🏃🏻‍♂️ = ✅

Great to meet up with former visiting student Guangbing,give a talk, & discuss research at Tongji University - another day of great hospitality!

🏃🏻‍♂️ = ✅, ready for the day ahead 😃

Had a great couple of post-conference days around Hangzhou, visiting West Lake & Lingyin Temple

Check out this new paper from Stefan Lechner's lab showing with minflux nanoscopy how PIEZO1 channels cluster and invagininate the membrane. Glad we could make a small contribution to this nice story! www.science.org/doi/full/10....

Lovely morning in Hangzhou: Friday short 🏃🏻‍♂️ = ✅

👨🏻‍🏫 = ✅, thanks @merrylabnotts.bsky.social for the photo!

Conference 3 of trip about to kick off, 10th Asian Federation of Laboratory Animal Science Associations Congress, my keynote is this afternoon, rather a large hall! Always great to have the opportunity to discuss the work that our group undertakes 😃 #neuroskyence #PainResearch

Lovely morning in Hangzhou - all set for day ahead: 🏃🏻‍♂️ = ✅