Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization. Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity. #PainResearch #Autoimmunity

I realized reading Dear Reader, the Unauthorized Autobiography of Kim Jong Il that some extraordinary men can see mitochondria with their naked eyes just walking around so I’m not surprised.

The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social

Webinar – 8 September Artificial Intelligence (AI) in Exploratory Human Research Register: bit.ly/478tBk2 ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns. #PainEducation

Please consider donating. This is an incredible resource that is the foundation for so much of what we know in biology.

very well done video on what is happening to basic health research right now all over the US: www.nytimes.com/2025/08/24/o...

Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing. www.biorxiv.org/content/10.1...

The list of the latest published pain papers is out now on PRF! Dr. Qiufu Ma's curated list for August 15-21, 2025 and his choice for Editor's pick can be found here: painresearchforum.org/paper @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

Really enjoyed going to see the Steeler's preseason game yesterday! The Steeler's played well but in the end lost to Tampa Bay. It was my first time to a Steeler's game and I have to say I enjoyed it. Although it was very hot!

This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF

Hats off to lead author Tony Lim who drove this project from writing the fellowship application, to establishing new techniques in the lab. We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA. Next step, in vivo!

Just posted on Pain Research Forum! Dr. Greg Scherrer's curated list of pain-related papers published August 1-7, 2025 and his choice for Editor's pick. Check it out at painresearchforum.org @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

Check out our new paper in Nature Communications! CRMP5 is a central regulator of pain and DRG hyper-excitability!

What do you think Li et al.’s findings in @natcomms.nature.com of a non-canonical dynorphin receptor does to change our understanding of the endogenous opioid system? bit.ly/3J9hxoA #EditorsPick #PRF

‘Congress has your back’: US senators tell scientists they want to protect NIH budget www.nature.com/articles/d41...

Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #migraine#podcast #newepisode #PRF

cool explainer thread ⬇️

We're hiring! Nature Neuroscience is hiring an Associate or Senior Editor with experience in cellular and molecular neuroscience, glia, and genomics to work in our New York or Shanghai office. Applications are due August 19. springernature.wd3.myworkdayjobs.com/en-US/Spring...

Check out this most recent webinar on improving trust in clinical trials. An incredibly important topic!

The #nihHEALinitiative is an amazing program And I hope it can continue! This is the type of science we need more of!

Amazing new paper out on KCC2 expression in human spinal cord! Love the translational potential of these findings. Seems like chloride dysfunction could be really important in chronic pain! Great work @tedpricethepainguy.bsky.social, Mike, Yves, and the team! #Science

Of course it was supported by the #nihHEALinitiative 💜💜

And a whole lot of reviewers who want to give their colleagues and field a fair shot at progress, even as they themselves struggle. SROs and POs can’t do anything if we can’t get those grants through peer review!

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

How do you think this article from Cai et al. in @cp-neuron.bsky.social can help us continue to understand the gut-brain-pain connection in #fibromyalgia? bit.ly/4lYjvX8 #fibromyalgia#PRF #EditorsPick

What do you think of Abdelkader et al.’s recent study in @painthejournal.bsky.social. reporting rejuvenation of aging mice with the transfer of young serum, including normalized mechanical sensitivity and alleviated postsurgical mechanical pain? bit.ly/4eDCcgd #PRF #EditorsPick

Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar where @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social, and more outline how to produce reliable evidence bit.ly/44GBtGP

Check it out! Amazing new resource through the Pain Research Forum!

Check it out! Dr. Juliet Mwirigi hosts a lively discussion with a panel of leading migraine researchers and clinicians. What successes have we had in understanding and treating it and what challenges do we still face? Produced by Lite Yang and Dr. Adam Dourson. Listen here: tinyurl.com/397vvar5

Do you agree that Title et al.’s report in @science.org suggest a regulatory mechanism that tune dorsal horn output in acute pain conditions and could contribute to pain chronification? bit.ly/3GDIaRN #PRF #EditorsPick

Check out this great opportunity!

So proud of Lyuba Salih as she defends her PhD at SLU! Watching her grow, tackle tough questions, and become the scientist she is today has been one of the best parts of my job. #PainResearch

USASP is currently participating in virtual Hill visits to educate congressional staff about the importance of NIH funding for pain research.🎉 Want to help? Help us make your voices heard. Reach out to your representatives and share why pain research matters to you. Learn more here ⬇

How could the recent pilot study involving the popular weight-loss drug liraglutide described in @nature.com by @marilenharo.bsky.social change the trajectory of #migraine treatment? bit.ly/44aLIE8 ##migraine#PRF

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

Carl Sagan in 1986 on the problems with media and science literacy.

"Commercial success in these areas grew out of basic research in computer science and solid-state physics in universities, funded by the federal government. With a bottom line to consider, for-profit businesses likely would not have started these disciplines from scratch" We need basic science!

It was a great pleasure to work on this project with Emmanuel Bourinet's lab revealing expression and function of T-type Ca Channel Cav3.2 in the human DRG: academic.oup.com/brain/advanc...

This is the truth of science. Breakthroughs can't always be predicted. Translation depends on basic science!!

Check out our newest article about how stress can worsen post surgical pain. we developed a new monoclonal antibody therapy that can prevent worsening of post-surgical pain specifically in female mice. link.growkudos.com/1eayfcuwbgg

Amazing example of the power of federally-funded research in the U.S. 🧪 "[it] began decades ago with federal funding for basic research on bacterial immune systems. That led eventually, with more federal support, to the discovery of CRISPR... www.nytimes.com/2025/05/15/h...

This is a huge deal! The harm to science cannot be over stated!

Surgeries are a common source of #pain in the clinic. Check out our new paper published today in PNAS exploring how stress can lead to enhanced pain after surgery. We found that targeting prolactin can improve outcomes in females. @pnas.org www.pnas.org/doi/10.1073/...

This was a great showing of the strength of pain research here at Pitt! Amazing showing for the first annual #PainDay!