Counting the days to @IASPpain’s World Congress on Pain 2026 in Bangkok? Make the wait easier by revisiting #PAIN’s collection of articles from the 2024 plenary speakers bit.ly/3K7OuT6

In this week’s #PAIN Featured Image, Ridehalgh et al. analyze T2 weighted images of the brachial plexus, dorsal root ganglia, and median nerve at the wrist. Learn more at bit.ly/4nnyQSj

Billens et al. find little consistent link between genetic/epigenetic variants and altered pain modulation in CMP. Dynamic pain measures appear robust, but more reproducible research is needed. Learn more in #PAIN bit.ly/4nhEgxT

Wei et al. find an increased risk of opioid use disorder and opioid overdose among older adults who experienced uncontrolled and high-impact pain after prescription opioid therapy. Learn more in #PAIN bit.ly/3HnqBWs

The October 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/3YGaclU

Jones et al.’s exploratory region-of-interest approach revealed widespread associations between limitations in normal activities due to pain and white matter microstructure in male but not female youth. Learn more in #PAIN bit.ly/3HnqAlm

This week’s #PAIN Featured Images are from the 4th and final entry in our essay series on the past Editors-in-Chief of PAIN. Learn more about Frank Keefe’s fascinating life and career in Williams et al. bit.ly/4ntoMHz

Karoam et al. find that lesions associated with central poststroke pain localize to a nociceptive pathway to a greater extent than lesions that are not associated with pain. Learn more in #PAIN bit.ly/3HnqE4A

Todd et al. find emerging evidence that interpretation biases are a treatment target that can be modified for improved pain outcomes. Learn more in #PAIN bit.ly/4lhSBJa

Taylor et al. assert that racialized, gendered, and rank-based inequities in low back pain follow-up visit and administrative action receipt in active duty service members require mitigation. Learn more in #PAIN bit.ly/3HnqzOk

Counting the days to @iasp.bsky.social’s World Congress on Pain 2026 in Bangkok? Make the wait easier by revisiting #PAIN’s collection of articles from the 2024 plenary speakers bit.ly/3K7OuT6 #PAIN#PainAwarenessMonth

The forebrain circuits that regulate pain modulatory circuits during hyperalgesia are unknown. Crawford et al. identify forebrain activity and forebrain-brainstem connectivity that underpins nocebo hyperalgesia. Learn more in #PAIN bit.ly/46MK8Ki

This week’s #PAIN Featured Image comes from Suñol et al.’s study of resilience in juvenile fibromyalgia. Clusters represent global connectivity increases in the JFM subgroup; psych term associations visualized via wordcloud. Learn more in #PAIN bit.ly/46FWeF4

Early career researchers: does the prospect of peer review feel daunting? Check out this free webinar from #PAIN EiC @karenddavis.bsky.social and #PAINReports EiC David Yarnitsky bit.ly/4nl5pzK #PAIN#PAINReports#PainAwarenessMonth

Ryu et al. find that invasive neural recordings of patients with chronic pain revealed that higher pain levels were associated with increased regularity in spike-like events within the 4- to 15-Hz band. Learn more in #PAIN bit.ly/46HTsPH

Palermo et al. find that parent distress moderated the effects of digital cognitive-behavioral therapy on adolescent sickle cell disease pain. Learn more in #PAIN bit.ly/45jrTK1

This #PainAwarenessMonth, we’d like to highlight an excellent resource for early career researchers: How to Peer Review Pain Research webinar by #PAIN EiC @karenddavis.bsky.social and #PAINReports EiC David Yarnitsky bit.ly/4nl5pzK

Bergeria et al. find that cannabidiol enhances acute hydromorphone analgesic effects. When hydromorphone was combined with higher doses of cannabidiol, more adverse effects and participant-rated Bad Effects were observed. Learn more in #PAIN bit.ly/45n7Jit

#PAIN is proud to highlight work from early career researchers. If you have questions about publishing in the top journal devoted to pain research, we’d love to hear from you! #PainAwarenessMonth

Alayoubi et al. find that myrcene, a terpene found in cannabis, dose-dependently attenuated allodynia associated with nerve injury by engaging CB1 receptors without producing negative reinforcement or direct activation of CB1 receptors. Learn more in #PAIN bit.ly/3HnqzxO

In this week’s #PAIN Featured Image, Medina et al. depict the setup of their high frequency stimulation experiment. They found that find that immersive nature virtual reality reduces the development and spread of mechanical hyperalgesia. Learn more at bit.ly/3HnqEBC

Throughout 2025, #PAIN has been publishing a series of essays recognizing past Editors-in-Chief in celebration of our 50th year of publication. Learn about the founding editors as the journal continues this special 50th anniversary series. bit.ly/4mrI2Vd#PAIN#PainAwarenessMonth

This #PainAwarenessMonth, we’re celebrating 50 years of #PAIN. Here's a rare glimpse of some recent print issues in EiC @karenddavis.bsky.social's office. Can any of our subscribers beat this collection?

In humans and rats, McKibben et al. find that early life adversity is associated with a greater duration of musculoskeletal pain and mechanical hypersensitivity after traumatic stress exposures during adulthood. Learn more in #PAIN bit.ly/3GZqm3W

2025 is the @IASPpain Global Year About Pain Management, Research, and Education in Low- and Middle-Income Settings. Check out our collection of relevant articles in #PAIN bit.ly/3Csdwso#PAIN#painawarenessmonth

Have you ever wondered how some of the leaders in the pain field got their start? Check out this essay from @painthejournal.bsky.social about PRF editorial board member, Allan Basbaum, to learn how he became the journal’s 3rd Editor-in-Chief bit.ly/3JIJTXf #PRF #PainAwarenessMonth

Have you wondered about the factors associated with opioid craving, intake, and misuse in patients with #chronicpain? Check out this study from Bruneau et al. and @painthejournal.bsky.social to see the results bit.ly/3I4H5mH #chronicpain#PRF #PainAwarenessMonth

Evans et al. find that symmetrical (mirrored) bilateral limb pain is more prevalent than previously thought. Pain is facilitated between mirrored contralateral regions and inhibited between nonmirrored contralateral regions. Learn more in #PAIN bit.ly/46N1t62

This #PainAwarenessMonth, we’re celebrating 50 years of PAIN. Our anniversary essay series highlights the life and work of past Editors-in-Chief—the first three are available for free right now! bit.ly/46mpCiT

The studies reviewed by Bedwell et al. show that some drugs reduce magnitude and/or area of secondary hypersensitivity, highlighting the need to clarify physiological mechanisms and clinical relevance. Learn more in #PAIN bit.ly/3Jmqaw5

September is Pain Awareness Month. We’ll be highlighting content from #PAIN related to weekly themes—stay tuned as we share more throughout the month.

Sun et al. used exosome visualization technology to reveal that upregulation of Rab27a increased primary sensory neurons-derived exosomal miR-1306-3p and activated spinal P2X3R, thus contributing to chronic visceral pain. Learn more in #PAIN bit.ly/45t6MFm

This week’s #PAIN Featured Image comes from Donna Hammond’s new essay on the life and work of Allan Basbaum. Here we see Allan flanked by close collaborators Howard Fields, Gail Martin, and David Julius. Learn more at bit.ly/4leGMmQ#PAIN#PainAwarenessMonth

We invite you to read the third in our series of essays on the past Editors-in-Chief of #PAIN. In this piece, Donna Hammond writes about Allan Basbaum and finding joy in pain research. Read for free at bit.ly/4leGMmQ#PAIN #PainAwarenessMonth

Mohammadian et al. find that minocycline, a tetracycline antibiotic, may neither reduce translocator protein positron emission tomography signal nor clinical pain in adults with chronic low back pain compared with a placebo comparator. Learn more in #PAIN #PainAwarenessMonth bit.ly/4liyxGm

2025 is the @IASPpain Global Year About Pain Management, Research, and Education in Low- and Middle-Income Settings. Check out our collection of relevant articles in #PAIN bit.ly/3Csdwso#PAIN#painawarenessmonth

To do no harm, we must first “know harms” Our new perspective piece on the challenge of measuring and reporting adverse events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa... @iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social

Rau et al. argue that the ICD-11 chronic pain specifiers for pediatrics are reliable and user-friendly but should not be the sole basis for therapeutic or reimbursement decisions. Learn more in #PAIN #PainAwarenessMonth bit.ly/3H1CAZT

The September 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/3UwqdZ1#PAIN#PainAwarenessMonth

Birkinshaw et al. review the literature on that parent mental health, cognitions, and behaviors predict child pain. Partner evidence is weak. Studies miss complex interpersonal dynamics. Learn more in #PAIN #PainAwarenessMonth bit.ly/4lfZDxO

September is Pain Awareness Month. We’ll be highlighting content from #PAIN related to weekly themes—stay tuned as we share more throughout the month.

Chang et al. find that insomnia may impact pain perception and inhibition in females with chronic low back pain. Integrating sleep assessments is essential for comprehensive treatment strategies. Learn more in #PAIN #PainAwarenessMonth bit.ly/4ldlXrV

This week’s #PAIN Featured Image depicts topographies of the 5 microstate classes that best explained the data from Jaltare et al.’s study. Learn more at bit.ly/45M6w4z

Baumbach et al. find that rates of early postoperative opioid administration vary in German hospitals. Patients on wards with higher rates report slightly better pain-related outcomes on the first postoperative day. Learn more in #PAIN bit.ly/3HnqxGc

Chronic pain linked to infections affects millions, yet ICD-11 poorly captures overlapping mechanisms. Ostermann et al. propose adding a subgroup for infection-related pain to improve diagnosis, treatment, and global equity. Learn more in #PAIN bit.ly/3URjGb6

Badzińska et al. analyzed the literature on calibration of stimulus intensity in pain research. They found 2 main methods and 3 techniques, but 69% didn’t test effectiveness. No method proved best; inconsistent reporting hinders replication #PAIN bit.ly/46NG8JG

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

De la Peña et al. profile translation in the dorsal root ganglion in a model of paclitaxel and uncover a novel post-transcriptional regulatory network that controls the nonselective sodium leak channel. Learn more in #PAIN bit.ly/46LPyoR

In this week’s #PAIN Featured Image, Shi et al. depict the multilevel mechanisms of tFUS neuromodulation: altering connectivity between pain regions, boosting blood flow, reducing neuroinflammation, modulating ion channels, reshaping synaptic plasticity bit.ly/45mXKtf

Pham et al. show that spinal GAT1 transcription via the STING-TBK1-IRF3-GAT1 pathway modulates mechanical hypersensitivity in paclitaxel-induced neuropathy. Learn more in #PAIN bit.ly/3HnqCtu