Did you know that dermal dendritic cell and epidermal Langerhans cell numbers are increased in #CRPS? Check out Allan Basbaum’s #EditorsPick from Karrasch et al. in @painthejournal.bsky.social bit.ly/492G1u9 #CRPS#EditorsPick#PRF

Episode 4 of Pain Exchange is out now! In this episode we hear about @painthejournal.bsky.social newest article type, Pain Essays, with Dr. Jane Ballantyne as well as @ksluka0101.bsky.social custom artwork for the cover of the journal’s 50th Anniversary supplementary issue! bit.ly/3JznbkG

In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH

Bree et al. find that augmented activation of Gq-coupled signaling in visual cortex astrocytes, which does not produce cortical spreading depolarizations, is sufficient to drive CGRP-mediated meningeal nociception and migraine-related pain behaviors. Learn more in #PAIN bit.ly/4oD55N9

Kalingel Levi et al. find that higher vagal tone correlates with reduced pain sensitivity in autistic adults, suggesting parasympathetic activity may modulate pain processing despite overall autonomic dysfunction. Learn more in #PAIN bit.ly/4pQhNsU

Barakat et al. investigated the contribution of bone tumor microenvironment to multiple myeloma bone pain by mapping cell-cell communication between bone marrow cell types and sensory neurons. Learn more in #PAIN bit.ly/48gpOBo

In a novel murine model, Schillebeeckx et al. find that catheter-associated UTIs associated with biofilm formation cause bladder pain and reduce voiding efficiency and mean urethral flow rate. Learn more in #PAIN bit.ly/48rhm2t

Meyer et al. find that the kinase GCN2 regulates neuronal sensitization and mechanical allodynia in response to a reactive glycolytic metabolite. Learn more in #PAIN bit.ly/43SpEgM

In this week’s #PAIN Featured Image, Rollet et al. summarize the risk and protective factors for acute pain at the time of birth among women delivering with epidural analgesia. Learn more at bit.ly/4hH7wwa

Morgan et al. find that chronic pain symptoms stay largely stable during short no-treatment periods, with only tiny improvements in pain and disability and no change in mood. Learn more in #PAIN bit.ly/4oT2hMa

As an accompaniment to this new perspective piece on measuring harms in pain research, the recording of our webinar "Assessing harms in pain research" is now available. @iasp.bsky.social @iasp-mesisig.bsky.social @efic.bsky.social @britishpainsoc.bsky.social perc.iasp-pain.org/methodology-...

Suri et al. find that a person-dependent definition of “flare” among individuals with low back pain has convergent validity, as shown by its associations with pain intensity and pain interference. Learn more in #PAIN bit.ly/49DHYxX

Banerjee et al. find that natural variability in androgen levels in healthy young adolescent girls is not associated with experimental pain sensitivity, and pubertal stage does not impact these relationships. Learn more in #PAIN bit.ly/4oUnKnV#adole...

Alongside altered pain behavior, Abdelkader et al. find that aging mice display sex-dependent low-grade systemic inflammation. Rejuvenating aging mice with young serum restores serum homeostasis and normalizes pain phenotype. Learn more in #PAIN bit.ly/3WFYVAk

Runge et al. report that sleep terminology and definitions in CMP research are highly inconsistent, creating confusion and limiting comparability. Clear standards are urgently needed to strengthen the evidence base. Learn more in #PAIN bit.ly/3JnVnzI

Adamczyk et al. find that painful polyneuropathy exhibits enhanced spatial summation and impaired offset analgesia, highlighting specific dysfunctions in pain modulation and offering insights into neuropathy-associated pain mechanisms. Learn more in #PAIN bit.ly/47vgc5y

Liu et al. find that specific activation of a glutamatergic brain neural circuit can modulate trigeminal neuropathic pain by increasing glutamate release and enhancing neuronal activity. Learn more in #PAIN bit.ly/4hLWt4Z

Our first endeavour in understanding how endogenous cannabinoids (eCBs) contribute to pain sensitivity. in @painthejournal.bsky.social. We found that baseline, fasted eCB ligands are not associated with point estimates of pain sensitivity, except for pressure pain. journals.lww.com/pain/fulltex...

In this week’s #PAIN Featured Image, Grol-Prokopczyk et al. depict the percentage of review articles addressing specific axes of social difference. Sex/gender, race/ethnicity, and age have been the most common “independent variables” #PAIN bit.ly/43OI4Pt

Beveridge et al. find that children had increased odds for chronic pain in adolescence when their mothers reported chronic pain and greater anxiety symptoms or ineffective parenting earlier in childhood. Learn more in #PAIN bit.ly/47q68uu

@massih.bsky.social et al. assert that identifying pain-specific processes requires salience-matching noxious and control stimuli. Salience ratings fully mediate stimulus intensity and physiological arousal relationship, demonstrating adequacy for matching. #PAIN bit.ly/3LuWKgq

Jin et al. find that patients with painful bortezomib-induced peripheral neuropathy show reduced TRPV1 immunoreactivity on skin nerve fibers, associated with decreased thermal sensation and increased pain levels. Learn more in #PAIN bit.ly/3JJrpGm

Davis et al. find that KCC2 membrane localization in dorsal horn neurons is decreased in people with a history of chronic pain and/or opioid use. Learn more in #PAIN bit.ly/4oSW2rR

Roberson et al. emphasize the complexities of family relationship dynamics and their long-reaching effect on chronic pain incidence and persistence for underserved aging African Americans. Learn more in #PAIN bit.ly/3JIwSxb

Huerta et al. find that standard analgesics reliably reduce spontaneous neuropathic pain in preclinical models, mirroring clinical efficacy and highlighting the value of assessing non-evoked pain. Learn more in #PAIN bit.ly/4hHOvJU

Physiotherapists and patients collaborated as coresearchers in a multistage iterative co-design study, developing a novel resource to enhance pain science education implementation into clinical practice. Learn more in Wilson et al.’s paper #PAIN bit.ly/4onJ9WN

Adams et al. propose unifying existing principles into practical guidance for trial data documentation. Learn more in #PAIN bit.ly/3WDb3Cb

McCoy et al. find that the neurokinin-1 (substance P) receptor antagonist CP-99994 reduced mechanical allodynia but had minimal effects on facial grimacing in mice postsurgery. Learn more in #PAIN bit.ly/3LrkNwT

Have you heard of the INTEGRATE-Pain Core Outcome Sets for different pain categories? Check out this article from Bova et al. in @painthejournal.bsky.social special 50th Anniversary supplemental issue and clinical editor David Finn’s comment now bit.ly/49OheLa #PRF

📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission

Our lab has 2 new papers in the current issue of @painthejournal.bsky.social: The first study, by Georgia Hadjis, shows that motivational conflict, rather than resource competition, determines priority assignment when pain is concurrent to competing demands. journals.lww.com/pain/fulltex...

In this week’s #PAIN Featured Image, Nishimura et al. depict a schematic representation of the neural innervation in bone tissue, highlighting the pathways and types of nerve fibers involved in bone innervation. Learn more in #PAIN bit.ly/3WIf08B

Liu et al. find that the SARS-CoV-2 N protein exacerbates pathological pain, potentially by interacting with Nav1.7 and enhancing Nav1.7 currents in dorsal root ganglion neurons. Learn more in #PAIN bit.ly/3X0blTT

Su et al. find that the saphenous-sural nerve injury model reliably replicates key clinical features of neuropathic pain, including spontaneous and evoked pain behaviors, without introducing confounding motor deficits. Learn more in #PAIN bit.ly/4oYjOmr

Osagie et al. find that varying acute low back pain definitions influence predictors and transition rates to chronic pain, underscoring the need for standardized criteria to advance LBP research. Learn more in #PAIN bit.ly/3WFQpRW

Fialho et al. find that synaptojanin 1, endophilin A1, dynamin 1, and adaptor-associated protein kinase-1 mediate synaptic vesicle recycling and neurotransmission in nociceptive circuits in the spinal cord. Learn more in #PAIN bit.ly/3WIf08B

The November 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/40uZAYx

Rolová et al. find that long-term prescription opioid use is associated with an increased risk of death. Most of the excess deaths occurred in the younger population from unnatural causes. Learn more in #PAIN bit.ly/3LrhXrB

Gilron et al. find no difference between melatonin and placebo in the treatment of neuropathic pain. Learn more in #PAIN bit.ly/3WGK2xI

We’re very proud to announce that the 2025 supplemental issue of #PAIN is online now! Read about what to expect from the next 50 years of pain research: bit.ly/3IQ6hOq

Li et al. analyzed two large data sets to create progression models (pain forest) for chronic overlapping pain conditions and mental disorders. Learn more in #PAIN bit.ly/4oYpTzi

Giancotti et al. find that intrarostral ventral medulla delivery of ozanimod attenuates behavioral hypersensitivities by engaging noradrenergic/serotonergic inhibitory projections. Learn more in #PAIN bit.ly/3JKW8Tu

Brask-Thomsen et al. find that in diabetic polyneuropathy and type 2 diabetes, development of and relief from neuropathic pain was common over a 5-year period. Associated factors were investigated. Learn more in #PAIN bit.ly/3WGJYOu

In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz

Harrison et al. find that individual differences in pain adaptation are stable over time. Neural sensory and appraisal systems are implicated in this process. Learn more in #PAIN bit.ly/4nkc4up

Stemper et al. find that the bradykinin 1 receptor antagonist fulmetibant did not reduce pain scores vs placebo in patients with diabetic neuropathic pain in the phase 2a BRADiNP study. Learn more in #PAIN bit.ly/4gIvwP2

Using a virtual reality approach, Xu et al.’s study shows that biases in attention and interpretation of pain information are interrelated and uniquely, not synergistically, predict pain interference. Learn more in #PAIN bit.ly/425OEAv

Drummond et al. find that pain expands in patients with longstanding complex regional pain syndrome in line with signs of peripheral and central nociceptor sensitization. Learn more in #PAIN bit.ly/3KckZ2z

The November 2025 issue of #PAIN is now available! Catch up on the latest pain research at bit.ly/40uZAYx

New in #PAIN: “Predicting placebo analgesia responses in clinical trials: where to look next? A meta-analysis of individual patient data” by Lunde et al. bit.ly/4nnYciW