So true. I would argue that most basic biomedical science does not depend on p-values yet almost everyone ignores this. For instance, pharmacology as a discipline is almost entirely independent of p-values at its core. A statistical test is unneeded for how a ligand interacts with receptors.

First pub of 2026! Enjoy www.jneurosci.org/content/46/3...

Our latest preprint. More evidence that diabetic neuropathy is a neuro degenerative disease. Very proud of @ish1789.bsky.social and our whole PRECISION group who made this work possible. #HEALinitiative funded

Pretty cool session on autoantibodies in neuropathic pain 👀

🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ... Now published in Neuropsychopharmacology @npp-journal.bsky.social Open-access link: www.nature.com/articles/s41...

Meyer et al. find that the kinase GCN2 regulates neuronal sensitization and mechanical allodynia in response to a reactive glycolytic metabolite. Learn more in #PAIN bit.ly/43SpEgM

Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain www.science.org/doi/10.1126/... Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane

Pretty exciting to develop simpler, faster ways to target specific neuronal subtypes 🤩 I'm looking forward to seeing this be expanded and integrated in future pain studies ☄️ #PainResearch #Neuroscience #DRG #FACS

In this week’s #PAIN Featured Image, Weinrich et al. depict heightened spontaneous ACC activity during nitrous oxide exposure, revealed by calcium imaging and distinct neural clusters. Learn more at bit.ly/4oTY3ny 

Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.

Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social www.biorxiv.org/content/10.1...

In case you missed it: A new US population-based analysis shows significant increases in the prevalence of chronic #pain in the wake of the pandemic. The upsurges were clear for almost all pain sites considered in the study, including #migraine/head pain. migrainecollaborative.org/chronic-pain...

🚨 Please RT! We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain. Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged. Apply 👉 recruit.apo.ucla.edu/JPF10647 #Neuroscience #Postdoc

huge news for T-type Ca channels: ir.praxismedicines.com/news-release...

New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch

18 years since the Khanna lab began! Grateful to all the amazing trainees, collaborators, and to @ninds.bsky.social for their support. Excited for the next decade of chronic pain discoveries. Let’s keep the science cool, rigorous, and impactful! 🔬💥 #ChronicPain #CRMP2 #Nav1.7 #NeuroScience

Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization. Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity. #PainResearch #Autoimmunity

MSC News: A US population-based analysis shows significant increases in chronic pain prevalence, and of high-impact chronic pain, after the pandemic. The upsurges were apparent for almost all pain sites considered in the study, including head/migraine pain. migrainecollaborative.org/chronic-pain...

Attending #SfN2025 in San Diego☀️? Don’t miss the Dorris Neuroscience Center Symposium at @scripps.edu, happening right before the meeting. A great lineup of speakers to kick off your SfN week. Plan your trip accordingly and register for free here: www.eventbrite.com/e/dorris-neu... Please amplify!

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

Well, well, well: www.nature.com/articles/s41...

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience www.cell.com/cancer-cell/...

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41... This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes. #PainResearch

Totally agree. This is not at all true in my field of sensory neurobiology. We have collectively built an expansive understanding of how sensory neurons work with publications that have built on each other over decades and that are now leading to transformative therapeutics.

Gabapentin is widely prescribed for nerve pain, but it doesn’t work the same for everyone. We studied actual human sensory neurons from donors and found that some responded strongly - and others hardly at all. #fromlabtolife #neuroskyence #PainResearch 1/4

🚨 New @jama.com review: Gun violence survivors need more than emergency care. 🔹 68% report chronic pain 🔹 50%+ show signs of PTSD 🔹 75% leave hospital with bullet fragments 🔹 10% suffer reinjury UMSOM trauma experts urge better long-term care. 🔗 bit.ly/3UfHPIh #GunViolence #Healthcare #PTSD

Always good to step away from the bench and catch up with brilliant colleagues over food, drinks, and fun! #AcademicLife #SLU #PainResearch

Hope this paper gets some recognition. www.biorxiv.org/content/10.1... Basic pharmacological principles are kinda important for experimental design.

So proud of Lyuba Salih as she defends her PhD at SLU! Watching her grow, tackle tough questions, and become the scientist she is today has been one of the best parts of my job. #PainResearch

Do DRG neurons have an AIS or not? A challenger appears academic.oup.com/brain/advanc...

Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social doi.org/10.1101/2025...

Shout out to my co-first author Mahdi Dolatyari and all the other team members from the Porreca lab! @aubinmoutal.bsky.social and team made essential contributions to this study. Hoping to explore this more in the clinic with our MD collaborators! #Science #research

We developed a novel monoclonal antibody that prevented stress induced hypersensitivity in a humanized mouse model of post surgical pain. Hoping this will lead to rapid #translation to the clinic!

Surgeries are a common source of #pain in the clinic. Check out our new paper published today in PNAS exploring how stress can lead to enhanced pain after surgery. We found that targeting prolactin can improve outcomes in females. @pnas.org www.pnas.org/doi/10.1073/...

Job opportunity🥼 I'm looking for an engineer or junior researcher to work on a project analysing the links between adverse childhood experiences and pain. Previous experience in cellular imaging or electrophysiology +++ contact me if interested. Job located in the beautiful French Strasbourg city

🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...