A big thank you to NINDS and the NIH for this amazing opportunity. Looking forward to finishing up my training by learning new skills and exploring questions about descending modulation that could have implications for treating #chronicpain.

Excited to share that I received the NOA for my HEAL K99/R00 award! I am so grateful to my amazing mentors who helped me at all stages of my training and supported me to get this far! @sarahross1.bsky.social @rpseal.bsky.social @khannalabuf.bsky.social @frankporreca.bsky.social

First Castro Lab paper, brought to you by the hard work of Dr. Kathryn Braden @katybraden.bsky.social In this manuscript we investigate the role of endogenous enkephalin or dorsal raphe nucleus. We find that it is incredibly important for buffering negative affect 😱 www.nature.com/articles/s41...

Very proud to share this @usasp.bsky.social podcast episode featuring PRC postdoc Elisa Damo @elisadamo.bsky.social, one of the Top 5 Travel Awardees from the USASP Annual Scientific Meeting! @karapedsgastrodoc.bsky.social soundcloud.com/usasp/episod...

New work from the Moutal Lab @aubinmoutal.bsky.social shows FGFR3 autoantibodies aren't just markers - they drive small fiber neuropathy pain by directly sensitizing DRG neurons. #Neuropathy #Autoimmune #PainResearch

A big thank you to our incredible partner, @usasp.bsky.social for sponsoring the participation of a trainee at #NAPainSchool! We’re proud to work together in empowering future #pain researchers. 💫 👏 Welcome @hstratton.bsky.social @upittpress.bsky.social

This is going to be a terrific meeting. There is a pain session on the last day, which will be moderated by the one and only Ru Rong Ji. We also have a spinal cord session that should be very exciting, in addition to all the other great work that will be presented at the meeting.

We’re hiring! The University of Pittsburgh is recruiting a tenure-track faculty member in pain research to join the Department of Neurobiology and the Pittsburgh Center for Pain Research—an outstanding and highly collaborative community. Please share. More here: cfopitt.taleo.net/careersectio...

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026

Thanks @nbcnews.com for covering our #SciImmunoloy paper showing the role of IL-10+ monocytes in sex difference in #pain www.nbcnews.com/health/women... #neuroimmunology Original article in comments

Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️

Our paper is now out in Advanced Science ! This study adds our lab's work exploring how autoantibodies can directly drive pain, extending our previous work on CV2/CRMP5. Many painful neuropathies are shaped by autoantibody-driven mechanisms. There is more to come 😉 #PainResearch

We can finally share our latest findings and technical advances in the human DRG. For those who want to get the most from staining the human tissue, we are happy to share our last preprint! 🔬 www.biorxiv.org/content/10.6...

So true. I would argue that most basic biomedical science does not depend on p-values yet almost everyone ignores this. For instance, pharmacology as a discipline is almost entirely independent of p-values at its core. A statistical test is unneeded for how a ligand interacts with receptors.

First pub of 2026! Enjoy www.jneurosci.org/content/46/3...

Our latest preprint. More evidence that diabetic neuropathy is a neuro degenerative disease. Very proud of @ish1789.bsky.social and our whole PRECISION group who made this work possible. #HEALinitiative funded

Pretty cool session on autoantibodies in neuropathic pain 👀

🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ... Now published in Neuropsychopharmacology @npp-journal.bsky.social Open-access link: www.nature.com/articles/s41...

Meyer et al. find that the kinase GCN2 regulates neuronal sensitization and mechanical allodynia in response to a reactive glycolytic metabolite. Learn more in #PAIN bit.ly/43SpEgM

Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain www.science.org/doi/10.1126/... Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane

Pretty exciting to develop simpler, faster ways to target specific neuronal subtypes 🤩 I'm looking forward to seeing this be expanded and integrated in future pain studies ☄️ #PainResearch #Neuroscience #DRG #FACS

In this week’s #PAIN Featured Image, Weinrich et al. depict heightened spontaneous ACC activity during nitrous oxide exposure, revealed by calcium imaging and distinct neural clusters. Learn more at bit.ly/4oTY3ny 

Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.

Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social www.biorxiv.org/content/10.1...

In case you missed it: A new US population-based analysis shows significant increases in the prevalence of chronic #pain in the wake of the pandemic. The upsurges were clear for almost all pain sites considered in the study, including #migraine/head pain. migrainecollaborative.org/chronic-pain...

🚨 Please RT! We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain. Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged. Apply 👉 recruit.apo.ucla.edu/JPF10647 #Neuroscience #Postdoc

huge news for T-type Ca channels: ir.praxismedicines.com/news-release...

New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch

18 years since the Khanna lab began! Grateful to all the amazing trainees, collaborators, and to @ninds.bsky.social for their support. Excited for the next decade of chronic pain discoveries. Let’s keep the science cool, rigorous, and impactful! 🔬💥 #ChronicPain #CRMP2 #Nav1.7 #NeuroScience

Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization. Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity. #PainResearch #Autoimmunity

MSC News: A US population-based analysis shows significant increases in chronic pain prevalence, and of high-impact chronic pain, after the pandemic. The upsurges were apparent for almost all pain sites considered in the study, including head/migraine pain. migrainecollaborative.org/chronic-pain...

Attending #SfN2025 in San Diego☀️? Don’t miss the Dorris Neuroscience Center Symposium at @scripps.edu, happening right before the meeting. A great lineup of speakers to kick off your SfN week. Plan your trip accordingly and register for free here: www.eventbrite.com/e/dorris-neu... Please amplify!

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

Well, well, well: www.nature.com/articles/s41...

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience www.cell.com/cancer-cell/...

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41... This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes. #PainResearch