Our final contribution to this collaboration is now online. We obtained electrophysiological recordings of DRG/TG neurons and Fos+ neurons of spinal dorsal horn & vlPAG in 2 models of neuropathic pain to study the actions of a humanized P2X4R scFv #PainResearch www.sciencedirect.com/science/arti...

Back in the saddle! #PainResearch #ephys

⚡We are finally electrocuting DRG neurons in the @alleslab.bsky.social since moving to @cincychildrens.bsky.social! #PainResearch #ephys #NeuroSkyence

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

Elegant work highlighting an important aspect of PA activity in sciatic nerve injury-related chronic pain! journals.lww.com/pain/fulltex... #PainResearch

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

📸 Big day in the lab! Our new electrophysiology rig is officially up and running — huge thanks to everyone who helped make this happen. Excited for the science ahead! 🧠⚡️ @alleslab.bsky.social @cincychildrens.bsky.social #PainResearch

Almost ready to rumble! #ephys #PainResearch @cincychildrens.bsky.social

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41... This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes. #PainResearch

Thanks for the highlight of our recent work! #PainResearch @painresforum.bsky.social painresearchforum.org/paper/expres...

Our collaborative study with the de la Peña lab is now online! Here we analyzed ephys & transcriptomic actions of gabapentin on hDRG neurons. Kudos to co-first authors Jenna & @docnessmonster.bsky.social. Special thks to our donors & their families #PainResearch journals.sagepub.com/doi/10.1177/...

Now online - our studies of mouse and human sensory neurons in the context of visceral pain! #PainResearch journals.sagepub.com/doi/10.1177/...

A read only for the DRG nerd: "Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons". www.nature.com/articles/s42...

Great week for Nav channel work - this time it's Nav1.9 from the Bosmans lab www.science.org/doi/10.1126/...

Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine pubmed.ncbi.nlm.nih.gov/40424150/ #PainResearch

Lab outing for a Reds game and we beat the Cubs... go @reds.com!

Good times at the Cincy Neuroscience Retreat connecting with neuro people @cincychildrens.bsky.social & UC and exploring trails of Ohio! #neuroskyence

Lovely preprint with some thought-provoking findings from Diane Lipscombe's group www.biorxiv.org/content/10.1...

First day! @cincychildrens.bsky.social #PainResearch

🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...

This is shaping up to be a pretty cool collection of papers! If you're interested in submitting something, give me a shout. #PainResearch www.frontiersin.org/research-top...

Our book chapter on the role of CCK in nociception & pain is now online! @docnessmonster.bsky.social #PainResearch www.sciencedirect.com/science/arti...

Made it to Cincy and I found the trail! 🏃‍♂️

@unm.edu it's been real. Off to start the next adventure soon @cincychildrens.bsky.social #PainResearch

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

Congrats to the newly minted Dr. Goins who passed with DISTINCTION!!! 🎉🎉 #PainResearch

Excited to be a part of this latest preprint from the de la Pena lab exploring the circRNA landscape in hDRG! #PainResearch www.biorxiv.org/content/10.1...

Super proud of @goinsyeah.bsky.social getting her thesis to her committee today!! You got this! 🍻#PainResearch

All kids deserve to feel the love on Valentine's Day! Be sure to send a free e-Card to our patients by February 14: give.cincinnatichildrens.org/site/SPageNa...

Very cool paper from Tuan Trang's group at UCalgary! #PainResearch www.cell.com/neuron/fullt...

📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells. authors.elsevier.com/sd/article/S... #neurobiology

Please help us advertise this new opening 🧠 in our research group. I am happy to answer any queries about it.

Disruptions in membrane lipid nanodomains in nociceptor DRG neurons increase HCN2 channel activity, leading to heightened neuronal firing and contributing to neuropathic pain. #PainResearch #Neuroscience" www.nature.com/articles/s41...

Our lab started human DRG electrophysiology studies @unm.edu We are excited about building this pipeline at @cincychildrens.bsky.social to help improve our understanding of human pain #PainResearch

Great way to kick off 2025 with a visit to see my buddy & fellow human tissue enthusiast @mikehildebrand7.bsky.social at Carleton University in my hometown 🇨🇦 #painresearch

It is with great pride that I share the bulk of thesis work from my first PhD Cand @goinsyeah.bsky.social on neuroimmune mechanisms of chronic back pain! This is a new direction for the lab led by Aleyah's sheer curiosity and drive. Congrats Aleyah! #PainResearch www.biorxiv.org/content/10.1...

Elegant paper from the Gereau lab examining intrinsic adaptive plasticity in mouse and human sensory neurons rupress.org/jgp/article/...

Looks like all members of the @alleslab.bsky.social will be moving! Most of us to Cincy & one of us for a great postdoc opportunity elsewhere. Excited to see great things from each of you! 💪👩‍🔬🔬 #PainResearch @docnessmonster.bsky.social @goinsyeah.bsky.social @drjones26.bsky.social

Riding the year out on a high ✨ - latest paper out now in @pnas.org! ☺️ 🙏 Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes! www.pnas.org/doi/10.1073/... #PainResearch #Neuroskyence More on this work below 👇 🧵 [1/10]

Our latest work in collaboration with the de la Pena lab on the effects of neuropathic pain drug gabapentin on human DRG neurons is now online!! Spoiler alert: interesting donor-specific actions! #PainResearch

We have an exciting postdoc opportunity to study the spinal circuits involved in spatial restriction of pain. Please spread the word and get in touch if you’re interested in joining our team. Application details to follow! @uclnpp.bsky.social @ucllifesciences.bsky.social #painscience #neuroskyence

@docnessmonster.bsky.social and I wrote a chapter for this on the role of CCK in nociception and pain! Pre-order your copy here if interested #PainResearch www.amazon.com/Cholecystoki...

Interesting work! #neuroskyence www.science.org/content/arti...

Happy Thanksgiving from the Sandias! #nmtrue

PhD opportunity with Carole Torsney in Edinburgh, "Developmental tactile and pain processing in Grin2b related neurodevelopmental disorder": sidb.org.uk/phds/torsney... #PainResearch

This looks great!

Thrilled to announce that the Alles Lab & family are moving! We will join the Dept of Anesthesiology at Cincinnati Children's Hospital next year. We look forward to continuing our work on molecular/cellular mechanisms of #chronicpain & starting exciting new projects soon 🎉🥂 #PainResearch

#FluorescenceFriday preprint coming soon! #PainResearch