🎉 Join us for the 1st NYC Area Pain Research Meet-Up! 🗓 Fri, Dec 5 | 3–6 PM 📍 NYU Pain Research Center, 433 1st Ave Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats! See you there! 💫 #PainResearch #NYCScience #Neurobiology

NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454

PRC PI Research Talks for the win! 🎉 Our guest speakers — Brian L. Schmidt, Edwin Rosado-Olivieri, and Nestor Jimenez — shared powerful research insights and sparked thoughtful discussion across the PRC community. A huge thank you to each of them for inspiring the work we do!

A new study: The Piomelli lab found that injury flips a metabolic switch in the spinal cord, fueling chronic pain. Restoring lost nutrients reactivates autophagy and stops pain from becoming chronic, hinting at diet-based ways to block pain persistence! www.sciencedirect.com/science/arti...

The Cancer Neuroscience Program at MD Anderson invites you to attend the International Cancer Neuroscience Symposium happening February 18–20, 2026, in the TMC³ Collaborative Building. mdanderson.cloud-cme.com/course/cours...

The latest in PNAS: Endosome-targeted nanomedicines deliver PAR2 antagonists directly to intracellular signaling hubs → producing sustained analgesia. A paradigm shift in GPCR-based therapy.

New research identifies a specific bacterial protease, Bfp1 from Bacteroides fragilis, that cleaves & activates host PAR2. This causes intestinal barrier disruption, sensitizes pain neurons, and triggers inflammation, leading to abdominal pain in IBD/IBS models. www.sciencedirect.com/science/arti...

Press release for 2 exciting papers from Bunnett and Jensen Lab researchers! #JensenLab #BunnettLab www.nyu.edu/about/news-p...

New Cell Host & Microbe paper alert! Chemoproteomics were used to uncover a previously unknown serine protease Bfp1 from B fragilis! This sneaky enzyme cleaves PAR2, setting off a chain reaction of barrier dysfunction, colonic inflammation, and nociceptor activation pubmed.ncbi.nlm.nih.gov/41015045/

Fascinating new work on the central mechanisms of sustained pain! A new study found an endogenous analgesic hub in the brain's parabrachial nucleus. Activity in neurons expressing the NPY receptor Y1 predicts chronic pain coping. www.nature.com/articles/s41...

Excited to share Bunnett lab's work on targeting compartmentalized GPCR signaling! Using endosome-accumulating nanoparticles, they selectively blocked intracellular PAR2, achieving complete, long-lasting pain relief in inflammatory disease models. www.pnas.org/doi/10.1073/...

A new study finds that reducing mitochondrial ETC activity shields TRPV1⁺ nociceptors from excitotoxic damage by limiting calcium and ROS, revealing a built-in neuroprotective strategy. www.sciencedirect.com/science/arti...

PRIMED Speaker Blake Kimmey (UPenn) Paging the PAG: Pain, Opioids & Relief. Epic talk on Periaqueductal gray opioid circuits for pain aversion & relief. Blake broke down how brain circuits in the PAG decide what hurts and what doesn’t. Stress, booze, and opioids all play a part!

Huge thanks to "3-Minute Mondays!" for this fantastic feature! Don't forget to subscribe @nyudentistry on #YouTube.... To learn more about the #NYU #PainResearchCenter. Click below to dive in! www.youtube.com/watch?v=naoQ... #YouTube #NYUDentistryoutubechannel #PainResearchCenter

Big congratulations to postdoc Sarah Najjar from the Margolis Lab on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏

🎉 Congrats to Dr. Moayedi on receiving the Whitehead Fellowship! This project explores how sensory feedback from upper airway muscles supports voicing—unlocking neural pathways with big implications for treating airway disorders. 👏🧠💬

The PRC PRIMED team is on fire! 🔥 They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled: "Understanding Enteric Neuroplasticity to Inform Regenerative Therapies." Exciting insights and cutting-edge science—well done, team!

Huge news! The Moayedi Lab has officially received their first R01 grant to study the neural mechanisms of astringency transduction and sensation! Can we get a whoop whoop hooray?! 🥳🎉🪩 @yaldamoayedi.bsky.social

A warm #welcome to Dr. Jordyn M. Boesch, our newest PRC Associate Member! 🐾 A board-certified veterinary anesthesiologist at Cornell, she’s now diving into translational research to bridge animal and human pain relief. #OneHealth #PainResearch blogs.cornell.edu/comparativep...

Thank you Brian Kim, MD, MTR for visiting the #NYU #PRC, giving a spectacular talk on neuroimmune interactions in bladder hypersensitivity and meeting with our members!

What a blast with Dr. Zhen Wang at PRC PRIMED! 🎉 His amazing talk, "An Interorgan Neuroimmune Circuit Drives Visceral Hypersensitivity," had us all engaged and inspired. #NeuroImmune #PRCPrimed #ScienceRocks 👏👏👏

PRC Highlight: Warm #welcome to Associate Member to the PRC! Kenny Chan, PhD studies how gut-brain-immune interactions under chronic stress drive depression and IBS—aiming to find targets to ease both neuropsychiatric and GI symptoms.

Flashback Friday! The PRC PRIMED was thrilled to welcome back Dr. Thomas Myers, a candidate in Dr. Robin Krimm’s lab at the University of Louisville. His engaging presentation, titled “Genetic Identification of a Fungiform-Innervating Low-Threshold Mechanoreceptor,” was a hit with everyone!

Amazing new paper from the Sadler Lab showing gut microbiota and metabolite contributions to pain in sickle cell disease. Congratulations to you and your team on this impressive work Kate! www.sciencedirect.com/science/arti... @katesadlerphd.bsky.social @utdpaincenter.bsky.social

PRC Highlight: We are excited to #welcome Dr. Yuki Miura as an Associate Member to the PRC. Yuki’s work leverages stem cell–derived organoids and assembloids to model human neural circuits -level disruption contributes to neurological disorders and pain! 🧪🧑‍🔬 #YukiMiura #PRC

The PRC & Molecular Pathobiology Dept made a splash at the NYU Plenary! Great catching up with Jeff Love, Lillian Moran, Gretchen North, Dr. Sasan Rabieh, Dr. Denise Trochesset, Nuray Ozu, Dr. Davide Cuocolo, Candy Tobar & more! Till the spring

New research identifies SLC45A4 as a pain gene, encoding a neuronal polyamine transporter that shows genetic association with human pain. #therapeutictarget #paintreatment www.nature.com/articles/s41...

PRC Highlight: #MargolisLab making strides again! Congrats to Chalystha Lee who received the 2025 ISSR Travel Award at the #ISSR2025 hosted in Vienna! With mentorship from Dr. Kara Margolis & Dr. Michael Gershon lighting the way. #mentorship #ISSR #womeninresearch @chalysthalee.bsky.social

A new study sheds light on a potential new way to treat migraine. Activating the nociceptin receptor (NOP) system can block the pain caused by CGRP. A peripherally restricted compound showed the same efficacy as a brain-penetrant one. bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

New research on COVID-19 and pain reveals something fascinating. Researchers found that the SARS-CoV-2 nucleocapsid (N) protein can intensify and prolong pain by interacting with a key pain channel, Nav1.7. This discovery could open the door for new therapies. journals.lww.com/pain/fulltex...

The Margolis Lab had a great time at #ANMS2025 in Minneapolis! Postdocs Sarah, Lin & Chalystha gave abstract talks, PRC Director Kara closed the conference, and we met Keynote Speaker & 2021 Nobel Laureate David Julius and his team! #ANMS225

Why does pain persist in rheumatoid arthritis even when inflammation fades? New review uncovers how ectopic nociceptor sprouting may be the missing link, offering fresh targets beyond antirheumatic drugs. link.springer.com/article/10.1...

Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

Fascinating new study on TMD! Researchers found that TMJ injury leads to persistent pain behaviors and peripheral sensitization of trigeminal nociceptors in mice, with distinct sex-dependent effects. buff.ly/jsFza40

Incredible! A new imaging system has allowed researchers to map the entire adult mouse peripheral nervous system at micrometer resolution. This is a massive leap in understanding cellular interactions in health and disease. #Neuroscience www.sciencedirect.com/science/arti...

Awesome new paper from the Khoutorsky Lab showing that transplanting healthy microbiota reduces fibromyalgia pain in mice and in humans! #microbiome #fibromyalgia #chronicpain www.cell.com/neuron/fullt...

Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 www.cell.com/neuron/fullt...

New model, New itch insights: Researchers created a mouse model where genetic tweaks in keratinocytes spark TRPV1 neuron–mediated neuropathic itch. A powerful tool to dissect itch circuits #Neuroscience #ItchResearch #ChronicItch #Gabapentin www.pnas.org/doi/10.1073/...

New study uncovers that Gαi acts as a pH sensor, where acidic conditions trigger structural changes that impair G-protein signaling by limiting Gβγ release. #GPCR #G-protein signaling #pH sensor

🧠💩 Pain in the Gut: Fusobacterium varium bacteria triggers IBS symptoms by hijacking Piezo2 signaling #GutMicrobiome #Piezo2 #VisceralHypersensitivity #Neurogastroenterology pmc.ncbi.nlm.nih.gov/articles/PMC...

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells buff.ly/Jafo68c

Fascinating work on neuropathic pain! Researchers found peripheral nerve injury enhances 4E-BP1-dependent protein synthesis in spinal microglia, pushing them to a reactive state and promoting pain. Excitingly, inhibiting this process reversed pain www.jci.org/articles/vie...

New research confirms Cav3.2 calcium channels in human DRG neurons! This study highlights their sensitivity to the clinical-stage blocker Z944 (but not ABT-639) and significant sex differences in expression. Great news for pain research and exploring Cav3.2 as a therapeutic target! buff.ly/Bz6MDsB

Longitudinal calcium imaging reveals distinct ALT neuron tuning to thermal/mechanical stimuli, with acute vs. chronic pain states driving divergent plasticity in spinal nociceptive coding #Spinalcord #Neuropathicpain buff.ly/3jzukkv

Revolutionizing pain relief: Discover groundbreaking strategies beyond opioids! This review unveils cutting-edge nonopioid analgesic strategies, from ion channel modulation to AI-driven pain assessment #painmanagement #nonopioidtargets

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

Fascinating new research! 🤯 A study reveals paracetamol's metabolite AM404 directly inhibits NaV1.7 & NaV1.8 sodium channels in peripheral sensory neurons to reduce pain. #PainResearch #Neuroscience buff.ly/FeCHdxG

A major step forward in non-opioid pain relief: NIH scientists report that a single intrathecal dose of Resiniferatoxin, a TRPV1 agonist, reduced severe cancer pain by 38% and opioid use by 57% in a Phase 1 trial #PainResearch #TRPV1 #Resiniferatoxin evidence.nejm.org/doi/full/10....

Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄

And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride