Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

The new glutamate indicators were announced today in @natmethods.nature.com. 🔗 www.nature.com/articles/s41...

In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH

A protons charge shapes electric fields in atoms - Learn how to choose the perfect telescope --> https://www.telescopeadvisor.com/how-to-choose-a-telescope.php and Get started with this beginners telescope --> https://amzn.to/3JaxN9u #Astronomy #AmazonAffiliate #NASA #Space

Day 16 #artAdventCalendar the woman who figured out why lead is particularly stable & 2nd woman to win the Nobel Prize for #physics 🧪🐡👩🏼‍🔬🎢 #histsci: German-American theoretical #physicist Maria Goeppert Mayer (1906-‘72). As the series of increasingly large atomic nuclei grows with additional nucleons🧵

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

This is one of those stories where every interview had me like 🤯🤯🤯. For @nature.com Outlook, I dove into the surprising field of cancer neuroscience. Edited by the amazing @scchak.bsky.social www.nature.com/articles/d41... #neuroskyence

The study shows how individual fingerprint ridges deform when we touch different textures, revealing how subtle stretching and shifting along the ridge flanks may drive our remarkably fine tactile sensitivity. buff.ly/4z67Vf1

🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗​​https://unc.peopleadmin.com/postings/308455 #Neuroscience #TeachingJobs #AcademicJobs #HigherEd

Robots don’t just “think”—someone codes their brain. AI doesn’t “learn”—people design its rules. If we want these systems to be just, fair, and brilliant, we need diverse coders shaping the algorithms. #STEMEducation #Robot #Robotics #NoireSTEMinist #STEMForAll #CSEdWeek #CSPowersAI #STEAM

A new blog about our recent three publications on the Nociceptive Apparatus Paradigm #painresearch #physio #neuroskyence painlosophy.wordpress.com/2025/12/06/t...

Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.

Fantastic thread on voltage vs calcium imaging. Via photon flux change per molecule per action potential, they’re similar. What makes voltage imaging so much harder, then? Integration time (EPSPs/APs are short), lim ability to jam GEVIs into membrane, and small size of subthreshold Vm changes. 🧪🧠🤖

PRC’s very own Associate Director, Steve Davidson, PhD, took the spotlight as our Keynote Speaker at the 1st NYC Area Pain Research Meet Up! 🎤✨ Talk Title: Humanizing Pain Neurobiology for Translational Gain.

🚀 NAPS applications open this week! The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec. 📍 Apply Nov 28–Jan 31 👉 northamericanpainschool.com/registration/

I take on average 10,000 stills and a half hour of video every week. Most I'll never think about again. This I'll hold onto until I grow old. 4 hours ago. Zero edits. No recoloring. No cropping. Nothing. Just straight up reality. 🦑

PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️

#BookSky I have not been reading as much as I want lately so big reviews have been on hold. I finished off Haruki Murakami's Dance Dance Dance. Fun to read, it was OK. I tried Hermann Hesse's Steppenwolf. Also, just OK. Maybe it's a sign of growth these literary characters aren't packing a punch. 🤷

Reposting this as a reminder to check back when this book comes out 👍

Pretty exciting to develop simpler, faster ways to target specific neuronal subtypes 🤩 I'm looking forward to seeing this be expanded and integrated in future pain studies ☄️ #PainResearch #Neuroscience #DRG #FACS

🎉 Join the 1st NYC Area Pain Research Meet-Up! 🗓 Fri, Dec 5 | 3–6 PM @nyupainresearch.bsky.social , 433 1st Ave, NY, NY Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats! Registration below 👇 💫 #PainResearch

The Maldives just became the first country to ban tobacco for an entire generation. Anyone born on or after Jan 1, 2007 can never buy or use tobacco — residents and tourists included. www.empr.com/news/maldive....

📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission

Help: We have developed an organoid model of diabetic neuropathy. It has oligodendrocytes, myelin, and adding diabetic stimuli makes them lose myelination, and break down mitochondria. Further yet, we show this can be prevented with pharmacological intervention. Which foundations may like this?

Brain-wide single-neuron bases of working memory for sounds in humans https://www.biorxiv.org/content/10.1101/2025.11.10.687666v1

unbelievable

People moan about AI taking people’s jobs, so interact and keep demand high for in person jobs - Go to the post office when you need to renew/post/register things - Go to the bank and get money out - Go to the shops and spend money, stop buying online - Go use public transport - Go to the library

Very grateful to be at the right place and the right time to run alongside a champion. #NYC #NYCMarathon #Legend #Kipchoge

Important announcement 📣 i’m serving face i’m sorry

So true. But then MORE THINGS arrive to get done. And that's just rude.

Post a non-religious photo you think of as holy #PainResearch #Neurons #PatchClamp

That’s exciting!

New human DRG atlas just dropped! 🌟

Despite some controversy, a science giant has fallen to the very thing he showed a great mastery of; biology. #Biology #Neuroscience #genetics

Excited to announce my thesis paper with is now in print at ELIfe! Excited to share our updated work on automating evoked touch/pain assays in rodents, and the further advancements we’ve made for #PainResearch! elifesciences.org/reviewed-pre...

When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!

Novel perineural invasion (PNI) mouse model mimics the intractable pain of head & neck cancer in humans 🤯, revealing that cancer-related nerve damage shares features with neurodegeneration. 🧠 Crucial tool for testing future pain treatments! 📈 #NYU #PainResearch #PNI #HNSCC

A blood test for pain? New work in Nature identifies circulating biomarkers that distinguish chronic pain states—offering a path toward objective, biologically grounded diagnostics. #PainResearch #Neuroskyence #Biomarkers #ScienceWatch #SciComm #ScienceInTranslation #ChronicPain

Incredible! A new imaging system has allowed researchers to map the entire adult mouse peripheral nervous system at micrometer resolution. This is a massive leap in understanding cellular interactions in health and disease. #Neuroscience www.sciencedirect.com/science/arti...

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

pubmed.ncbi.nlm.nih.gov/40699432/ #PainResearch #NeuroSkyence #Neuron #Neuroscience Inhibiting mRNA quality control in nociceptors reveals pathways driving chronic pain. Must read!

Grant list for general #ECR postdocs and faculty, with additional dedicated lists for #neuroscience / #neuroskyence and #cancer / #oncology A huge thank you to @deniswirtz.bsky.social & team for this collection

We are hiring! Tenure-track position in Neurobiology in the Department of Biology at the University of Nevada, Reno @unevadareno.bsky.social. 🧪🧠 #neuroscience #neuroskyence jobs.sciencecareers.org/job/674336/a...

Lately, I've pivoted to reading scientific literature and not books. I'm sad my book review posts have slowed down because of this. So I'm going to post my to-be-read book list before 2026 instead... #BookSky #ScienceLiterature #NonFiction

🧪 Philadelphia area Neuroscientists: This is a great opportunity to meet other area neuroscientists and share your work as a speaker (postdoctoral fellow) or with a poster (anyone with data!) www.spinephilly.org #neuroscience #Philadelphia #neuroskyence 🧠

One of the Astronauts from the golden era 🧑‍🚀 passing is news that stirs up the calling to reach above and beyond. Honored to have been alive at the same time as these talented individuals. 🙌

Like my mama always said “nothing is as it seems”, “it could be better than you think” 🤔 🌈 The meditation tonight is to sit deep in anxiety, look around the room and observe the chaos inside, it could be the most insightful and fruitful experience yet. 😘 #BlueSky #HOPE #Hallelujah

20 minute walks. 🦋👩‍🍳💋