In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH

Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

Check out articles like “Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain” by Martin et al. in #PAIN bit.ly/3YxTyUV

Bavencoffe et al. find that hyperexcitability in nociceptor somata isolated from ganglia innervating painful and nonpainful regions suggests new functions for widespread, ongoing nociceptor activity. Learn more in #PAIN bit.ly/3G4Y5rB

Check out articles like “Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats” by O’Brien et al. in #PAIN bit.ly/3S2xpe3

PRC Highlight: Congrats to @pazduran.bsky.social for "Best Poster Presentation Finalist in Basic Science" Titled "Compartmentalized Signaling Of Mas-related G-protein Coupled Receptor X1 (MrGPRX1) And Transient Receptor Potential Vanilloid (TRPV) Channels In Pain And Itch Pathways"👏 #USASP_2025

Amazing talk by @tedpricethepainguy.bsky.social on progress in our understanding of pain mechanisms using human DRG and spinal cord. Really cool data on spinal projection neurons in human spinal cord. This is quite amazing!

Congrats to all the poster award winners at #usasp2025! Very proud of my friend Paz Duran who won an award for her amazing work!

Amazing times with @nyupainresearch.bsky.social at the @usasp.bsky.social meeting. Congratulations to all our post docs including @pazduran.bsky.social @sarahanajjar.bsky.social for their amazing presentations! @nyupainresearch.bsky.social @newyorkuniversity.bsky.social

Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week! #USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels

HOWZAT!! Amazing paper 🤩 Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/... Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉

CaV1.3 channels are vital for dopamine neuron function. We found that mutant LRRK2 (G2019S) enhances their activity via CaVβ3 phosphorylation, a potential key factor in Parkinson's disease. #neuroscience #ionchannels #ParkinsonsDisease #LRRK2 #CaV1.3 www.mdpi.com/1422-0067/26...

NaV1.8/NaV1.9 double knockout mice show their combined role in pain signaling & altered gene expression in DRG neurons. Valuable for studying human pain mutations #ionchannels #pain #neuroscience

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

PRC Highlight: @nyupainresearch.bsky.social Dr. Steve Davidson was featured in The New York Times- offering his insights on a BMJ review that examined studies on non-surgical, interventional treatments for low back pain nytimes.com/2025/03/18/w... #nyuniversity #NYUDental #NinaAgrawal @nytimes.com

PRC Highlight: The Jensen Lab is making strides in understanding diseases at the molecular level — paving the way for #future breakthroughs in #oral health and beyond #NYUDentistry #nyuniversity #Jensenlab #3minutemondays

Detailed characterization of VGSCs (Nav1.7, 1.8, 1.9) in pain-sensing neurons. Reveals new insights into their roles in action potential generation and pain disorders #painresearch #ionchannels

🔬We study the dorsal root ganglion (DRG), which is a cluster of cells located just outside of the spinal cord. The DRG routes pain signals from the periphery to the central nervous system. #FluorescenceFriday #sciart #neuroart

@nyupainresearch.bsky.social Shoutout 📢 to The NYU Molecular Pathobiology for #hosting an amazing tea time #Mardi #Gras style! #Brazil #Zamba #Turnupthursdays #Happymardigras 🪅🎉🎊🪩💃🕺🏼 #NYUDental #newyorkuniversity

European Calcium Channel Conference 2025 Early registration and abstract submission are still open until March 10, 2025! For additional information, please visit the meeting website: calciumchannel.eu and for registration: calciumchannel.eu/registration... #calcium #channelopathies #ionchannels

PRC Highlight: Achievement Announcement #Jensen's #Lab at the @nyupainresearch.bsky.social DDS student #BrandonBloom was selected to present his research at the New York Academy of Dentistry and was recognized with an #award for outstanding work! #Congratulations 🍾🥳 #NYUDental #NewYorkUniversity

Macrophages in diabetic neuropathy delay sensory axon loss, providing neuroprotection against nerve damage #PainResearch #Immunecells #Neuroscience

Migraine frequency matters! 🤯 New study shows repeated migraines sensitize BOTH male & female mice to CGRP, impacting treatment efficacy #Migraine #CGRP #Neuroscience

Impressive article showing that probiotic treatment, by suppressing inflammatory pathways, can reverse the pain of diabetic neuropathy in rats #painresearch #microbiomeresearch

How does spinal cord stimulation (SCS) relieve pain? 💡 New study shows SCS inhibits NK1R+ neurons in the spinal cord, key players in pain transmission #PainResearch #SCS #Neuroscience journals.lww.com/pain/fulltex...

#Contulakin-G (CGX), a conotoxin targeting the neurotensin receptor 2 (NTSR2), shows promise for cancer-induced bone pain, acting via #Cav2.3 channels #PainResearch #Neuroscience #Conotoxins #NTSR2 journals.lww.com/pain/fulltex...

Tyler Nelson (who we are actively collaborating with at UF in @khannalabuf.bsky.social lab) and Robert Gregg (who used to be at UTD, and whose work I deeply admire) were very brave to speak up for this new article in NY Times: www.nytimes.com/2025/02/22/s...

PRC Highlight: Awesome presentation given by #postdoc Marcella de Amorim Ferreira on, “The role of #endocytosis in synaptic #transmission in #itch” hosted by our NYU Molecular Pathobiology- Work in Progress seminar series! #painresearch #itchresearch #circleJLabs🥳🍾👏

@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch

C2230, a novel CaV2.2 blocker that relieves pain by stabilizing CaV2.2 in an inactivated state, reducing neurotransmitter release—without motor or cardiovascular side effects. It’s effective across multiple pain models and delivery methods! @pazduran.bsky.social www.jci.org/articles/vie...

A compound with potential for managing diverse pain conditions! @khannalabuf.bsky.social @shestehave.bsky.social & team identify C2230 that targets Ca2+ channels & relieves neuropathic, orofacial, and osteoarthritis pain in models: https://www.jci.org/articles/view/177429

Its @khannalabuf.bsky.social day at Journal of Clinical Investigation!! Check out this great paper from his lab: www.jci.org/articles/vie...

Structures and anti-epileptic drug binding site resolved for native GABA-A receptors from patient tissue. Wow! www.nature.com/articles/s41...

🎉 Happy Valentine's Day, we love you science! ❤️ #FluorescenceFriday #sciart #neuroart

Panx1 is a key regulator of sex differences in neuropathic pain. While spinal Panx1 activation drives pain in both sexes, it does so through distinct immune pathways #SexDifferences #PainResearch www.sciencedirect.com/science/arti...

@NYUPainResearchCenter a #HUGE shout out and warm #WELCOME to @sdavidson.bsky.social PRC is extremely excited for this new addition to our Lab! 👏🥳 #anamanu #stevedavidsonlab #newbies #labfam #paineurobio #ephys

Excellent writing from @dereklowe.bsky.social : What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog... I think I would have appreciated it equally with the curse words.

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

Voltage-gated sodium channels as drug targets tinyurl.com/39ymf5jd rdcu.be/d8JJY The pioneering non-opioid drug for pain approved by the FDA last week, suzetrigine, targets the sodium channel NaV1.8. Read about drugs targeting NaV channels for epilepsy, muscular disorders and pain in this new Review