Sarah Najjar
@sarahanajjar.bsky.social
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Postdoc Fellow at NYU studying gut-brain axis and pain disorders
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Sarah Najjar
Kate Sadler
15 days ago
1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia!
www.cell.com/cell-host-mi...
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Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00338-5
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reposted by
Sarah Najjar
Nature Reviews Gastroenterology & Hepatology
6 months ago
#GastroEdPick
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
@cp-cell.bsky.social
www.cell.com/cell/fulltex...
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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.
https://www.cell.com/cell/fulltext/S0092-8674(25)00258-2?rss=yes
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reposted by
Sarah Najjar
Ardem Patapoutian
8 months ago
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition:
chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
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Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
https://chng.it/kK2HMP5pGk
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So excited this paper is finally out!!!
add a skeleton here at some point
10 months ago
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reposted by
Sarah Najjar
CLaE
10 months ago
Current Biology Interoception and gut–brain communication
www.cell.com/current-biol...
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Interoception and gut–brain communication
The brain senses changes to the internal state of the body, eliciting responses that maintain homeostasis. Alhadeff and Yapici provide an overview of this process, termed interoception, with a particu...
https://www.cell.com/current-biology/fulltext/S0960-9822(24)01389-7
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reposted by
Sarah Najjar
Katrina Ray
10 months ago
NEW in
#NatureReviewsGastroHep
! This Review on gut-brain axis & pain signalling in the gut By Kim Meerschaert & Isaac Chiu
www.nature.com/articles/s41...
🔓
rdcu.be/d1dFo
🧪
#gastrosky
#GIsky
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The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract - Nature Reviews Gastroenterology & Hepatology
Visceral pain is a major clinical issue, most commonly associated with gastrointestinal disorders. This Review discusses molecular mechanisms by which neurons are sensitized in the gut, outlining sign...
https://www.nature.com/articles/s41575-024-01017-9
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