Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karapedsgastrodoc.bsky.social jamanetwork.com/journals/jam...

A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karapedsgastrodoc.bsky.social doi.org/10.1016/j.ns...

Huge congratulations to PRC Associate Director Steve Davidson on securing an NIH R01 to investigate new targets for diabetic neuropathic pain! #painresearch @sdavidson.bsky.social @yysquare.bsky.social @karapedsgastrodoc.bsky.social

NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social

New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. www.sciencedirect.com/science/arti... @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social

Congratulations to the Margolis Lab on their standout translational study published in Gastroenterology! @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social

We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social

Come see us at our presentations today at #USASP2026! @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @afshin419.bsky.social @mariafialho.bsky.social @sarahanajjar.bsky.social @goinsyeah.bsky.social

Don’t miss Dr. Kara Margolis’ talk this afternoon at #USASP2026 on serotonin signaling in the gut-brain axis! @karapedsgastrodoc.bsky.social

Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social

NEW PRC PREPRINT 🚨 The Thomsen Lab identifies a shared hydrophobic “hotspot” within GPCRs that mediates direct competition among their transducers, pointing to a universal mechanism that regulates receptor access & desensitization. buff.ly/OAtZd9X @karapedsgastrodoc.bsky.social

NEW PRC PAPER 🚨: Research from the @adesgeorges.bsky.social Lab with @harsh3b.bsky.social reveals that beta-arrestin 1 actively drives cell signaling, not just as a scaffold, but as a direct activator. #StructuralBiology #GPCRs buff.ly/4BfXcYz @karapedsgastrodoc.bsky.social

Very proud to share this @usasp.bsky.social podcast episode featuring PRC postdoc Elisa Damo @elisadamo.bsky.social, one of the Top 5 Travel Awardees from the USASP Annual Scientific Meeting! @karapedsgastrodoc.bsky.social soundcloud.com/usasp/episod...

Congratulations to Haoming on graduating from New York University with a Master of Science in Biology from the Graduate School of Arts and Sciences! 🎓✨ Wishing you all the best in your next chapter, we’re so proud of you! @karapedsgastrodoc.bsky.social

Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

More shots from our PRC Symposium yesterday. We were grateful to host wonderful keynote speakers: Dr. Walter Koroshetz, Dr. Lin Chang, Dr. Jeffrey Hubbell, and Dr. Ru-Rong Ji! @karapedsgastrodoc.bsky.social

Highlights from the 2026 Pain Research Center Symposium! Dr. Kara Margolis presented: “Compartmental Serotonergic Signaling in Gut–Brain Health: Clinical Implications for Mood and Abdominal Pain” Thanks to everyone for a great day of science! @karapedsgastrodoc.bsky.social

The Margolis Lab was proud to be represented by six poster presenters at the 2026 Pain Research Center Symposium! Congratulations to: Sarah, Daniel, Chalystha, Lin, Rahi, Taeseon Great job to everyone who presented and contributed to a fantastic day of science! @karapedsgastrodoc.bsky.social

ConGRADulations, Mariam! 🎓 It has been a pleasure having Mariam in the Margolis Lab through NYU Dentistry's TRIP&ICE program. We are so proud of all she has accomplished and wish her the very best in her next chapter! @karapedsgastrodoc.bsky.social @chalysthalee.bsky.social

Look who stopped by NYC from across the globe! Felt like worlds colliding having my PhD PI @elimelb.bsky.social and postdoc PI @karapedsgastrodoc.bsky.social in the same room. So fitting on Intl Day of Women&Girls in Science to celebrate two brilliant women who paved the way for me!

Such a great day at @nyupainresearch.bsky.social gathering with NYC-area Pain Scientists. Excellent science and people. Thank @karapedsgastrodoc.bsky.social @sdavidson.bsky.social for hosting, my buddie organizer @justinburdge.bsky.social and everyone joined and oresebted! See you next year!

The 1st NYC Area Pain Research Meetup was a roaring success! What started as an idea from @dr-lupo.bsky.social and myself turned into an incredible gathering with the help of @karapedsgastrodoc.bsky.social, and her team at @nyupainresearch.bsky.social. #PainResearch #Neuroscience #Neuroskyence

Happy holidays from the Margolis lab! Pic after a hard core karaoke party😂

Shoutouts to @nyupainresearch.bsky.social @vabraira.bsky.social @dr-lupo.bsky.social @sdavidson.bsky.social @karapedsgastrodoc.bsky.social for helping organize!

New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues. @karapedsgastrodoc.bsky.social 🔗 www.nature.com/articles/s41...

@chalysthalee.bsky.social did an amazing job presenting at the ISSR! Such a well-deserved travel award and so proud to have her representing the lab!!

A new study shows that food structure plays a key role in determining which gut hormones are released. @karapedsgastrodoc.bsky.social #GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege 📖 Nature Metabolism www.nature.com/articles/s42...

🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌ Game-changer for gut health. sciencedirect.com/science/arti... #guthealthmatters #WBAIL2 @karapedsgastrodoc.bsky.social

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)

🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity

Round two- ding ding! 🥊 Time for an AMPIRS photo dump that’ll knock your lanyard off 😎🚨poster session 2 coming in 🤳📸 picture perfect!👌

And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride

Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄

New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults. @vivtawfik-mdphd.bsky.social @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...

IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells @karapedsgastrodoc.bsky.social www.pnas.org/doi/10.1073/...

@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @amergastroassn.bsky.social PRC Website: dental.nyu.edu/research/pai... Margolis Lab: dental.nyu.edu/faculty/mole...

Yes! Your taste buds do talk to your brain🧠! Thank you Dr. Nirupa Chaudhari for a fantastic talk! #brain #NYUdentistry #PRC

Tea 🫖 Time ⏰! Happy monthly birthday shoutout! #PRC #NYUdentistry #NYU #MPB 🎂🥳🎈#happybirthday

A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....

Green light for pain relief! 🟢 Researchers found green light therapy reduced osteoarthritis pain in rats, via analgesic endolipids engaging the endocannabinoid system. #PainResearch #GreenLight #Osteoarthritis journals.lww.com/pain/fulltex...

🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter

#PRC Highlight: Happy Flash back Friday! Flashing Back to Cinco De Mayo! 💃🕺🏼🪇 MPB Tea Time always celebrating in style! #PRCpride #teatime #🫖 #cincodemayo #flashbackfridays #thankyou #PRC

New research reveals prolactin as a driver of stress-induced post-surgery pain in women. Blocking prolactin shows promise for better pain management & reduced opioid use! #PostoperativePain #Prolactin #PainResearch www.pnas.org/doi/10.1073/...

Great talk given to the PRC PRIMED Club by guest speaker Manon Bohic on Spinal Oxytocin Modulates Touch Reward and Pain Relief Through Shared Dorsal Horn Circuits. Manon Bohic is a research associate at Rutgers University.👏 #Thankyou for the visit! #SpinalDorsal #PRC #womeninscience