Wondering about pain and circadian rhythms? SCN→SPZ→PVN→vlPAG circuit maintains daily rhythms in pain sensitivity, but is dampened at night. www.science.org/doi/10.1126/...

Excited this paper is out @Cell This work explores the role of MOR and SST interneurons in ketamine’s antidepressant effect and identify synergistic approaches to develop new therapeutics. Big shoutout to @hmunguba.bsky.social who led the project and all the team doi.org/10.1016/j.ce...

Excited to share our new study on how the brain generates placebo pain relief! We developed a mouse model that recapitulates key features of human placebo analgesia, then used it to identify causal circuitry. www.sciencedirect.com/science/arti... today.ucsd.edu/story/neurob... 1/n

Such a great day at @nyupainresearch.bsky.social gathering with NYC-area Pain Scientists. Excellent science and people. Thank @karapedsgastrodoc.bsky.social @sdavidson.bsky.social for hosting, my buddie organizer @justinburdge.bsky.social and everyone joined and oresebted! See you next year!

Great structure work about MOR binding states from the Cornelius Gati lab! Congrats to all the authors, particularly Saif Khan. Looking forward!

Very cool findings about the connection of touch and mating processes! www.nature.com/articles/s41...

So cool! 👇🏼👇🏼👇🏼A β-arrestin-2-biased modulator of neurotensin receptor 1 relieves acute and chronic pain by blocking neural sensitization while also reducing opioid abuse risk without affecting motor or cognitive functions www.cell.com/cell/abstrac...

A bit late but definitely proud of my first talk @INRC2025!

Defensive behaviour and dPAG 🐭 www.nature.com/articles/s41...

My first time at #usasp2025. Great science, new and old friends. First talk in a symposium at an international conference. Thank you to my co-speakers @stefpuig.bsky.social and Ream Al-Asani

our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology open access, open data and code w/ @drsmschabrun.bsky.social jamanetwork.com/journals/jam...

Excited to present our lab's new work on GPCR antagonism: Contrary to popular belief, we propose that inverse agonists can bind to and act via GPCR:G protein complexes. We show this at KOR, through cellular assays, radioligand binding and cryoEM studies. A thread. 💊 🧪 www.nature.com/articles/s41...

Excited to share our new preprint here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz, @dirktrauner.bsky.social @gati.bsky.social and Seva Katritch's labs! 👇🏻👇🏻 www.biorxiv.org/content/10.1...