Nature Reviews Gastroenterology & Hepatology (@natrevgastrohep.nature.com)

Rethinking B cells in ulcerative colitis: a CAR T cell opportunity Nature Reviews Gastroenterology & Hepatology, Published online: 14 November 2025; doi:10.1038/s41575-025-01154-9A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions. https://www.nature.com/articles/s41575-025-01154-9?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro