It's such a good week for preprints! Looking forward to reading this one www.biorxiv.org/content/10.1... #PainResearch

We present the first subset-specific proteomic signature of electrophysiologically-defined, pain-sensing neurons. One step closer to uniting function with molecules- one neuron at a time. Thanks to all who have contributed, especially @coscialab.bsky.social @garyrlewin.bsky.social #neuroscience

Fantastic piece in Nature Reviews Neuro by @nicolecrust.bsky.social on the importance of science communication. My take? Everything matters - just do something. It will make a difference for how science is valued and trusted, how community understands. Let's get out there and communicate! 👏

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

This week’s #PAIN Featured Image comes from Suñol et al.’s study of resilience in juvenile fibromyalgia. Clusters represent global connectivity increases in the JFM subgroup; psych term associations visualized via wordcloud. Learn more in #PAIN bit.ly/46FWeF4

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN: www.biorxiv.org/content/10.1...

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss. rdcu.be/eGU0W

This #PainAwarenessMonth, we’d like to highlight an excellent resource for early career researchers: How to Peer Review Pain Research webinar by #PAIN EiC @karenddavis.bsky.social and #PAINReports EiC David Yarnitsky bit.ly/4nl5pzK

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

2. www.nature.com/articles/s41...

Have you ever wondered how some of the leaders in the pain field got their start? Check out this essay from @painthejournal.bsky.social about PRF editorial board member, Allan Basbaum, to learn how he became the journal’s 3rd Editor-in-Chief bit.ly/3JIJTXf #PRF #PainAwarenessMonth

A very interesting and stealthy property of RNAs once they get modified by glycosylation:

A new #MachineLearning platform called Fentanyl-Hunter described in #ScienceAdvances can screen for opioid metabolites in biological and environmental samples. https://scim.ag/4gawS4U

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch www.science.org/doi/10.1126/...

Our department at UT Southwestern Medical Center has openings for TT faculty position! Our Neuroscience Research Division has diverse research programs, from genes to neural circuits to human brain imaging. UTSW has a vibrant/growing neuroscience community! www.nature.com/naturecareer...

UC Davis is hiring! A tenure-track assistant professor of psychology, in human cognition or cognitive neuroscience #psychjobs recruit.ucdavis.edu/JPF07300

The 50th anniversary of PAIN essay series highlights the life and work of past Editors-in-Chief—the first three are available for free right now for #PainAwarnessMonth! bit.ly/46mpCiT

September is Pain Awareness Month. We’ll be highlighting content from #PAIN related to weekly themes—stay tuned as we share more throughout the month.

Sun et al. used exosome visualization technology to reveal that upregulation of Rab27a increased primary sensory neurons-derived exosomal miR-1306-3p and activated spinal P2X3R, thus contributing to chronic visceral pain. Learn more in #PAIN bit.ly/45t6MFm

Have you seen the latest result from the Julius lab showing mitochondrial electron transport chains tuning as an intrinsic cellular strategy protecting nociceptors against excitotoxicity? Check out this #EditorsPick from @alexchesler.bsky.social now! bit.ly/46jodto #EditorsPick#PRF

Your regular post-conference reminder that bsky is a great place for pain researchers ⬇️

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

Excited to share our development of a novel model of TMD pain lead by @daspainbrain.bsky.social with @andpru.bsky.social!

🎙️ Our #QPRNmember Prof. @jeffreymogil.bsky.social (@mcgill.ca) was on The Most Painful Podcast by the Chronic Pain Centre of Excellence. He discusses preclinical #research to understand #ChronicPain and develop new #treatments. 👇 www.spreaker.com/episode/insi...

18 years since the Khanna lab began! Grateful to all the amazing trainees, collaborators, and to @ninds.bsky.social for their support. Excited for the next decade of chronic pain discoveries. Let’s keep the science cool, rigorous, and impactful! 🔬💥 #ChronicPain #CRMP2 #Nav1.7 #NeuroScience

We invite you to read the third in our series of essays on the past Editors-in-Chief of #PAIN. In this piece, Donna Hammond writes about Allan Basbaum and finding joy in pain research. Read for free at bit.ly/4leGMmQ#PAIN #PainAwarenessMonth

A preclinical study in #ScienceSignaling identifies a mechanism behind the opioid paradox—where the long-term use of opioids leads to pain sensitivity—and hints that targeting this pathway may inform safer and more effective use of #opioids in pain management. https://scim.ag/4mKgieL

Per Jeff Mogil: “Every successful treatment out there started with an animal model,” he said. “Science works best when you let a thousand flowers bloom. Everyone can do the kind of work they want to do.”

My editor’s pick: painresearchforum.org/paper/mitoch... “...the findings suggest that nociceptors have evolved to “dial down” the ETC pathway, enabling them to be unusually resilient to oxidative and other intracellular stresses.“

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026. 🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others. 💡 Submit abstracts by the 26th of September, 2025: lnkd.in/eDhPUVKd 💻 More info: lnkd.in/eJw9pfMz

Doing my best to get better at this! You will see more and more from me as I try to communicate what we do, how we do it, and what it all means! Hoping to reach not just the science folks here on BS but non-scientists as well!

Join our next PURPOSE Network coffee chat! This informal drop-in session is a great opportunity to get your questions answered about the NIH HEAL Initiative PainCare Clinician Training Program (PCTP). Register now: painresearchers.com/events/138420

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...

We LOVE our trainees ! From @nihvigils.bsky.social today ❤️❤️

The list of the latest published pain papers is out now on PRF! Dr. Qiufu Ma's curated list for August 15-21, 2025 and his choice for Editor's pick can be found here: painresearchforum.org/paper @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

Check it out! An interview on pain mechanisms and therapeutics with Dr. Clifford Woolf, PhD, MB, Bch of Harvard Medical School by Julia Nickols at the North American Pain School is now posted on PRF! painresearchforum.org. @utdpaincenter.bsky.social @iasp.bsky.social @usasp.bsky.social

Hearing that all 27 NIH institutes have been instructed to stop using "paylines" in funding decisions starting Oct 1. Order issued in the last 48 hours. Using paylines means scientific peer reviewers control funding decisions. Removing them allows more political interference. 🧪 1/

this will never end: www.nytimes.com/2025/08/21/u...

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

I’ve resurrected my monthly newsletter, Notes on Pain eepurl.com/jh0VaM

Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to “write” proteins to do whatever we want them to do, is just remarkable …

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social pubs.acs.org/doi/10.1021/...

Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience www.cell.com/cancer-cell/...

The 2025 North American Pain School gathered 29 early-career scientists with global experts for a week of mentorship, collaboration & cultural exchange in Montebello, Quebec. IASP proudly supports NAPS and our full network of Pain Schools & Camps. Learn More: bit.ly/3Ujg1CL #NAPS2025

pssst...have you seen our new quick-guides for talking about science to your friends and family? #31daysofaction

Have any thoughts on our #EditorsPicks this week? Subscribe to the new PRF website, where you can receive monthly newsletters, comment on your favorite #PRF articles, and more! bit.ly/3U4yiUa#EditorsPicks#PRF#PRF

As others have said the effect of suzetrigine was barely/not significant from placebo in clinical trials, though data from the Bean lab shows an effect on NaV1.8 currents. I am thinking this may not be the ‘best’ target.