It is an all too common feature of academics, particularly grant funded scientist ones, to assume implicitly or explicitly that our systems select on pure merit. Right up until we, or our peeps, come up on the bad side of the dice roll. Only then is the system excoriated for being unfair.

In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz

In this week’s #PAIN Featured Image, @khannalabuf.bsky.social‬ et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz

New human DRG atlas just dropped! 🌟

Another excellent position at UT Dallas, this time in the Biological Science Dept: jobs.utdallas.edu/postings/30702 Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!

The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

🚨 Mark your calendars for #NAPainSchool 🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more! northamericanpainschool.com/registration/ #Pain #PainResearch #NPAW2025 #PrioritizePain

Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC

🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome. 🧠 Abstracts due Nov 2 – all published in a JGP special issue! 🔗 sodiumchannelconference2026.org/WELCOME/

🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease. 🧠 Abstracts due Nov 2 🔗 sodiumchannelconference2026.org/WELCOME/ #NaV #ionchannels #cardiacphysiology #scienceconference

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693

⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference! Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org #WSCC26 #SodiumChannels #PainResearch

The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...

The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...

Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species. Learn more in a new #SciencePerspective: scim.ag/43iprSX

It is depressing that we (i.e. the scientific community) can't break out of this bizarro world where publishing in a $$$ Journal is considered a valid proxy for high impact science.

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

We're excited to announce the official lineup for our in-person event! 🎉 There's one week left to sign up - registration closes Nov. 1st. You don't want to miss this! #StoriesOfWiN #SfN #WomenInNeuroscience

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩 More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

How is it that some nociceptors—the sensory neurons that detect heat, chemical irritants and toxins—can withstand a lifespan’s worth of exposure to noxious stimuli, whereas others die? New findings reveal how they do it. By @vcallier.bsky.social #neuroskyence www.thetransmitter.org/sensory-syst...

For anyone on the neuroscience job market, our ads are up. We are looking for anyone working in systems neuroscience of animals to join us in southern Alberta 🇨🇦 #academicsky #neuroskyence #neuroethology #academicjobs #Canada neurojobs.sfn.org/job/39049/as...

my department - medical biophysics - is seeking a new chair informal inquiries welcome please share www.uwo.ca/facultyrelat...

What do you think of Allan Basbaum’s comment on the #pain study featuring the peptide, Vulnusin - newly identified as an acute wound signal in drosophila larvae epidermal tissue, published by Guo et al. in @cp-neuron.bsky.social? Respond now! bit.ly/4qhENCc #pain#PRF

HUGE opportunity at Rutgers: jobs.sciencecareers.org/job/675694/d.... They already have such a dynamic pain group there, and such a great history... really an amazing opportunity.

Faculty position in Neuroscience at UT Austin: apply.interfolio.com/175280 A great Department and an exceptional scientific community in Austin and across the UT System.

We're extremely proud to announce #PAIN's 2025 supplemental issue: Advancing Pain Research and Management for the Next 50 Years. The entire issue is free to read on our website! bit.ly/3IQ6hOq

The cover art, painted by the brilliant Kathleen Sluka, shows a stairway symbolizing the many steps toward truly individualized pain research built on understanding the biological processes and factors that shape patient-reported outcomes. #sciart #neuroart bit.ly/4opxhDw

A special thanks to all the authors who contributed to this special issue, the leadership and vision of our Editor-in-Chief @karenddavis.bsky.social and all the scientists and clinicians who are paving the way to a brighter future for pain relief and management! bit.ly/3IQ6hOq

www.linkedin.com/redir/redire... Positive news for the calcium channel field, this is the T type calcium channel blocker Z944 developed by Terry Snutch!

New preprint from us: Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy www.biorxiv.org/content/10.1...

This is the original story that i wrote about the topic for The Transmitter. www.thetransmitter.org/craft-and-ca...

Never assume that you know all about what any drug molecule is doing in the body - where it's going, what it's binding to. A new example:

🎤 Call for Symposia Proposals topics related to clinical practice, basic science or mechanisms, and translational research related to pain. Ideally, presentations include multiple disciplines. The deadline to submit proposals is October 15, 2025

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

Just here to remind everyone that while the federal government is shutdown, all study sections at the NIH are currently on hold. Another blow to science and to early career scientists like myself with young labs and research groups. Very hard to remain positive about this career path.

This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology. rupress.org/jgp/article/...

Hey pain scientist! Looking for the latest papers on pain? Come check out #PRF's new #PapersoftheWeek selections from Allan Basbaum, who also commented on the latest Editor's Picks painresearchforum.org/paper/correc...

A variant of CRISPR amps up expression of SCN2A, rescuing mice from seizures caused by haploinsufficiency. By @cqchoi.com www.thetransmitter.org/spectrum/boo...

Our model also predicts dynamics of internal pain and effort states- which look intriguingly like two populations of neurons the Betley lab found during miniscope imaging of PBN!

We tried a handful of manipulations, but found that the only really reliable way to suppress pain-coping behavior was to gate out the pain input to the controller. Which PBN is well positioned to do, as it receives direct input from dorsal horn of the spine!

We then asked: computationally, what should NPY signals to to change how this model behaves? Our first guess was it should work by making coping behavior (licking) more 'expensive' in terms of effort, but in the face of a long-lasting pain input (persisting over an hour) this barely changed behavior

Computationally, how is NPY changing behavior? We formulated pain-coping as a control problem- say the goal of the brain is to minimize perceived pain with minimum "effort" (ie time spent attending to pain). Given this goal we can train models to produce 'optimal' behavior to minimize effort + pain

The work builds off of an amazing result from Amber Alhadeff-- paper: www.cell.com/cell/fulltex... essay: www.science.org/doi/full/10.... when mice are food-deprived, AgRP neurons projecting to parabrachial nucleus start releasing neuropeptide Y, and this mechanism suppresses pain-coping behavior.

Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain. A brief rundown... www.nature.com/articles/s41...

The Rutgers Brain Health Institute @rutgersbhi.bsky.social is looking for an accomplished scientist to serve as the Director of the new Rutgers Center on Research in Pain and Pain Therapeutics. Feel free re-post and/or reach out to me if you have any questions jobs.rutgers.edu/postings/225...