We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

The most November of weathers but we caught the first snowfall of the season

One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc

Nice opportunity for canadian #PainResearch folks abroad to feel a bit more connected, as well as any postdoc at a canadian uni!

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Every tech company eventually either reinvents the bus or reinvents phrenology

Subscribe to The Onion instead of whatever this shit is. Membership.theonion.com

the jetlag is real but it's always worth it for a leafy escape 🍁

it's cool that there are still elections

I do not regret to inform you that we are going to win

Can't say I'm surprised, but I'm certainly disappointed

I shouldn't be this nervous for a budget but oh my goodness we need a win

We’re so excited to share our exclusive Christmas jumper with you! 🦖🎄

Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC

Testimonies describe bodies in streets, families torn apart and days without food as paramilitary seizes Sudan city.

🗣️📢 Call for short essays, poetry and short fiction: LOOMING ‘zine (issue 2, winter 2025). Deadline: Dec 1 LOOMING is a technocritical zine celebrating the human and the analog in the face of Big Tech. CC @kconrad.bsky.social Submit to: [email protected]

all my gloves are now lost in leaf piles

FUCK WHY DID YOU GUYS LET ME TRY THIS IVE NEVER BEEN SO STRESSED IN MY FUCKING LIFE

We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693

time to learn how baseball works

The NIH has insisted there are no banned words But, an analysis by @jeremymberg.bsky.social found over 700 hundred grants changed their titles from '24 to '25 Some see it as a small price to pay to keep their grant, but others are worried about what comes next www.statnews.com/2025/10/29/n...

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

paper acceptance mondays are the best kind of mondays

introducing folks to all the ways you can use maple syrup, one belated thanksgiving at a time

My favourite thread from this year - working on a dream project and nothing like a new set of results to put a spring in our steps! 🤩🧬

the academic job market is bleak but at least I'm not close friends with JD Vance

It's that time of year again... time for #DisabledInSTEM 2026 Mentorship applications! I'm so excited to be running this program for the sixth year and seeing the growth over the years! Mentee form: forms.gle/um5DvYnBi3tn... Mentor form: forms.gle/BvaxnQm8uhUR... Applications due December 5th!

But seriously, I can’t wait for the first bubble to burst because it might actually be possible to have a conversation about what’s useful and interesting and what’s just more bullshit hype yelled in a circle

Registration is now open for the EuBIC-MS Winter School 2026! Join us in Harrachov, Czechia for a week of keynotes, workshops, and networking on computational MS. Info and registration: eubic-ms.org/events/2026-... #EuBIC2026 #MassSpectrometry #MassSpec #Bioinformatics #Proteomics #Metabolomics

"The EHRC’s exclusionary interim guidance has had a devastating impact on trans people’s lives" “Now the guidance has been withdrawn, so should the exclusionary policies that organisations rashly implemented in its aftermath. If not, they could find themselves in hot water.”

Still not over this paper..."Living organisms are assumed to produce same-species offspring" loool not here. www.nature.com/articles/s41...

#OnThisDay in 1920, the first women received their Oxford degrees 🎓 📷 | St Anne's College Oxford

These sunny lunch runs though

Don't mind me, just stress cleaning my code for a false sense of control over *points to everything*

When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!

Ok. But are there any downsides?

🤯

@asta-at.bsky.social did an amazing job leading this study, a first of its kind for neck pain!

The first publication of our project, which identifies altered gene expressions in the human DRG associated with neck pain. Fantastic collaboration with @tedpricethepainguy.bsky.social lab, Christoph Hofstetter from Neurosurgery, and a stellar team. urldefense.com/v3/__https:/...

We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.

Have you heard about the new MSc programme #PainResearch

That's quite the chart annotation. www.nature.com/articles/d41...

YES! THIS on GenAI! Please read this absolutely splendid piece of writing that had me cheering, a little bit weepy, and writing in the margins: "An extraordinary amount of money is spent by the AI industry to ensure that acquiescence is the only plausible response. But marketing is not destiny."

As Netanyahu addresses the United Nations in New York City this morning, the world recoils in horror at the ongoing genocide in Gaza.

This is incredible and so inspiring on so many levels. This is what science can do.

A single-cell spatial transcriptomic census of human skin anatomy https://www.biorxiv.org/content/10.1101/2025.09.22.676865v1

NEW WRITING: I talk about a new memoir that’s set to debut next week from Gazan physics student Wasim Said, aspiring astrophysicist, who has created a forceful record of the genocide. I also share parts of my conversations with Said. The book is a must read. #BookSky 🧪⚛️🔭

Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch