This is incredible and so inspiring on so many levels. This is what science can do.

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

My editor’s pick: painresearchforum.org/paper/mitoch... “...the findings suggest that nociceptors have evolved to “dial down” the ETC pathway, enabling them to be unusually resilient to oxidative and other intracellular stresses.“

The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social

We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...

I’ve resurrected my monthly newsletter, Notes on Pain eepurl.com/jh0VaM

Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities

Five years ago, a very close relative died of a glioblastoma brain tumor at the age of 13. Today would have been his 19th birthday. And now comes news that an mRNA vaccine is being trialed to treat this very (incurable) malady. Fingers crossed. mbi.ufl.edu/2024/05/01/v...

Phil and Penny Knight announced today a record-breaking $2 billion gift to the Oregon Health & Science University’s Knight Cancer Institute to transform the future of cancer care and set a new standard globally. Thank you to Phil and Penny Knight for their incredible generosity. #GiveCancerHell

Not actual fluorescence for #FluorescenceFriday, but this is pretty, colorful and something I am super excited about. Colors represent spatial clustering of gene expression in human basal forebrain at 2 levels (300um apart) of the lateral septum 🧠🔬🧪

After the past few days, it's more important than ever that we speak out against the war on science and research. Make your voice heard. Join us this Saturday: bit.ly/SoundScience....

pssst...have you seen our new quick-guides for talking about science to your friends and family? #31daysofaction

Katalin Kariko won the Nobel Prize for mRNA vaccine technology. She is certain that RFK Jr is endangering public health by killing $500 million in mRNA research www.thetimes.com/us/news-toda...

Have you checked out the relaunch of PRF? Editors’ picks are selected by rotating editorial board members like @gregscherrer.bsky.social @painresforum.bsky.social

Just posted on Pain Research Forum! Dr. Greg Scherrer's curated list of pain-related papers published August 1-7, 2025 and his choice for Editor's pick. Check it out at painresearchforum.org @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

‘Congress has your back’: US senators tell scientists they want to protect NIH budget www.nature.com/articles/d41...

At some point, the Republican project shifted from attacking scientific consensus on particular subjects that ran counter to their political interests to trying to shut down all scientific inquiry wherever it might be headed.

Why call? Why sign letters? Why protest? What does it do?? It. Adds. Up. And PRESSURE WORKS! Keep it up, Dorks! #StandUpForScience www.politico.com/news/2025/07... 14 Republican senators urge White House to release delayed NIH funds - POLITICO

Looking forward to some exciting #PainResearch / #Neuroskyence in our Symposium: "Not just neurons: pain is orchestrated in partnership with many non-neuronal cells" @cherylstucky.bsky.social / @mdburton.bsky.social / Anne-Marie Heegaard

Check it out! Dr. Juliet Mwirigi hosts a lively discussion with a panel of leading migraine researchers and clinicians. What successes have we had in understanding and treating it and what challenges do we still face? Produced by Lite Yang and Dr. Adam Dourson. Listen here: tinyurl.com/397vvar5

Check out our new, interactive website for preclinical and clinical pain researchers! Webinars, podcasts, interviews, job listings, meeting announcements, funding opportunities, Papers of the Week and more! painresearchforum.org

www.cell.com/cell/abstrac... !!!

JUST IN: The Trump administration is suing to overturn CA state laws intended to prevent cruelty against egg-laying chickens. The administration says these laws have driven up egg prices and are preempted by a 1970 federal law. storage.courtlistener.com/recap/gov.us...

Does everyone know there is a comment period re: changes in animal research at NIH? I didn't. Closes July 14. The scientific community need to respond en masse. I asked university leadership to distribute to reach our colleagues not on social media, you can too go.pardot.com/e/858023/duc...

From brain gain to brain drain: theconversation.com/turbulent-re...

Does anyone have Cre mouse line recommendations for comprehensive peripheral nerve labeling, other than Prph and Uchl1? Find more information about this request, respond, and make your own methodology inquiries at Pain Researcher now bit.ly/4etEHlb #PRF

Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar where @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social, and more outline how to produce reliable evidence bit.ly/44GBtGP

Excited to see this finally out! Projection-TAGs allows you to do multiplex high-throughput multi-modal profiling of projection neurons. www.nature.com/articles/s41...

#AltPride #AltGov To close out Pride Month, we are recognizing neuroscientist Ben Barres. Beyond making seminal discoveries related to glial cell function, he was also a staunch advocate for equality in science for both women and the LGBTQIA+ community. 1/n www.nature.com/articles/d41...

😅 Wouldn't want to know the weekly stable cost!

I rarely post personal things. But I need to talk about my 4-year-old niece, Hope. She has a rare disease. A drug called elamipretide has helped her survive. But the FDA recently denied its approval. Now, her health hangs in the balance. Please share her story & urge the FDA to reconsider. 🧵

A must read and share!

Former NIH director Francis Collins speaks out about why he left NIH: “I didn’t feel I could raise alarms about the harms that were being done to medical research. I was prohibited from speaking about it.” #medsky www.aamc.org/news/former-...

Thrilled to join the Rita Allen Scholars community (ritaallen.org/stories/2025...) and grateful for the support! Glad to (re)discover many inspirational colleagues as current and former award in pain scholars.

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...

@standupforscience.bsky.social represented in #Oakland,CA. incredible turnout including @danfeldman.bsky.social

Extremists have eviscerated the National Institutes of Health, responsible for 80% of the *world’s* grant investment in biomedical research The losses are incalculable, but here are several of them Thank you @propublica.org for documenting this —>

We need more PhDs in Congress. This interview with the ONLY PhD in congress has some good advice, like: universities and researchers in red states can get a group meeting with your Congress rep. federalnewsnetwork.com/budget/2025/...

BWJoneslab Moving To The University of Pittsburgh I can now officially reveal that we are moving the BWJoneslab from the University of Utah, Moran Eye Center to the University of Pittsburgh, Department of Ophthalmology, effective August 1st, 2025. bryanwjones.com/2025/06/bwjo...

Hey anyone want to be part of a BlueSky truth squad next week when Jay Bhattacharya testifies before Congress? Would mean live-skeeting the hearings. DM if interested so we can coordinate. #NIH #Science #MedSky #EpiSky

Women are disproportionately affected by chronic pain. @a2cps-pain.bsky.social et al. describe sex-specific mechanisms in the transition to chronic pain that may inform individualized approaches to pain management in both sexes. buff.ly/1vi5oNT

Cuts have consequences, illustrated. As seen on TV 📺

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...

How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With @vincentcostaphd.bsky.social and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test: www.biorxiv.org/content/10.1...

I hope Senator @johnfetterman.com and his team enjoy nonfiction books (or at least this one). Nearly everyone is either themselves afflicted with a brain or mental condition, or knows someone who is. We must do better for those individuals! To achieve that, we need federal support of science.

"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger” an $18 Billion cut Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced www.statnews.com/2025/05/30/n...

If "mental anguish" from watching the news is an actionable tort WE'RE ALL GOING TO BE RICH, BOYS!

The sense of sadness and despair that many of us who left countries, where science and research were not valued or that simply there were no resources, feel about the wanton and deliberate destruction of US science (a beacon for the world) is immeasurable.

This is the truth of science. Breakthroughs can't always be predicted. Translation depends on basic science!!