Alex Chesler
@alexchesler.bsky.social
📤 632
📥 388
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Touch, pain and coffee
reposted by
Alex Chesler
Pain Research Forum
3 months ago
Have you seen the latest result from the Julius lab showing mitochondrial electron transport chains tuning as an intrinsic cellular strategy protecting nociceptors against excitotoxicity? Check out this #EditorsPick from @alexchesler.bsky.social now!
bit.ly/46jodto
#EditorsPick
#PRF
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reposted by
Alex Chesler
Pain Research Forum
3 months ago
The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week!
painresearchforum.org/paper
@utdpaincenter.bsky.social
@nyupainresearch.bsky.social
@iasp.bsky.social
@usasp.bsky.social
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reposted by
Alex Chesler
Donald Iain MacDonald
6 months ago
Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science!
www.science.org/doi/abs/10.1...
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Sort of last minute but my group is looking to recruit a a recent college grad as postbac to start this summer and work on PIEZO channels. Project involves cell based assays, patch clamp recording, and imaging. Info on the NIH program can be found here:
www.training.nih.gov/research-tra...
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https://www.training.nih.gov/research-training/pb/pb/
6 months ago
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reposted by
Alex Chesler
Kara Marshall
6 months ago
Vote today for SfN leadership! Ellen Lumpkin and Irene Tracey both there!
www.directvote.net/SfN/
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DirectVote Election: Login
https://www.directvote.net/SfN/
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reposted by
Alex Chesler
Stephani Sutherland
7 months ago
The last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for
#painresearch
at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share!
heal.nih.gov/about/nih-he...
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The NIH HEAL Initiative 2025 Annual Report: Research in Action | NIH HEAL Initiative
https://heal.nih.gov/about/nih-heal-initiative-annual-report-budget/2025-annual-report
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reposted by
Alex Chesler
International Association for the Study of Pain (IASP)
7 months ago
Read this #PapersoftheWeek #EditorsPick from Ghitani et al. and @Nature.com demonstrating that nociceptor activity is both necessary and sufficient for inflammatory tactile allodynia
bit.ly/4mcTuV4
#PapersoftheWeek
#EditorsPick
#PRF
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reposted by
Alex Chesler
Quanta Magazine
7 months ago
The feeling of a hug comes from the pressure and vibration of millions of nerve endings.
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Touch, Our Most Complex Sense, Is a Landscape of Cellular Sensors | Quanta Magazine
Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has spent his career cataloging the neurons beneath everyday sensations.
https://www.quantamagazine.org/touch-our-most-complex-sense-is-a-landscape-of-cellular-sensors-20250416/
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Happy “May the 4th” or as I like to call it “Piezo Day”.
7 months ago
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reposted by
Alex Chesler
Lauren Atlas
7 months ago
Here’s just the most recent of the many NCCIH studies of
#pain
(from colleague
@alexchesler.bsky.social
published last week in Nature). Nearly 50% of NCCIH funding goes to studying pain, with a focus on nonpharmacological treatments and mechanisms. The proposed budget eliminates NCCIH.
add a skeleton here at some point
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reposted by
Alex Chesler
Todd Macfarlan
7 months ago
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply!
www.training.nih.gov/jobs/pdf-mb-...
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https://www.training.nih.gov/jobs/pdf-mb-070125/
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Four old men from NYC. Reunited to see a punk band that I last saw live at CBGBs in high school. Friends for four decades.
7 months ago
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reposted by
Alex Chesler
Zachary Knight
7 months ago
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata.
www.nytimes.com/2025/04/26/h...
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What Nearly Brainless Rodents Know About Weight Loss and Hunger
https://www.nytimes.com/2025/04/26/health/hunger-brain-ozempic.html
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An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here:
www.nature.com/articles/s41..
.
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https://www.nature.com/articles/s41..
7 months ago
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Huge congratulations to the always amazing, truly brilliant
@clairelepichon.bsky.social
who just received TENURE from our NIH intramural program.
7 months ago
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reposted by
Alex Chesler
Tim Behrens
7 months ago
add a skeleton here at some point
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www.science.org/content/blog...
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Pain Continues to Be a Pain
https://www.science.org/content/blog-post/pain-continues-be-pain
7 months ago
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reposted by
Alex Chesler
eLife
7 months ago
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
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Watch out Ozempic, there’s a new kid in town.
www.nytimes.com/2025/01/30/h...
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F.D.A. Approves Drug to Treat Pain Without Opioid Effects
https://www.nytimes.com/2025/01/30/health/fda-journavx-suzetrigine-vertex-opioids.html?smid=nytcore-ios-share&referringSource=articleShare
10 months ago
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Finished my holiday project. Gutted a $150 Gaggia Classic I found on Craigslist and turned it into a Gaggiuino (
gaggiuino.github.io#/
). Stop by my office for coffee sometime.
11 months ago
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Great start to 2025
11 months ago
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Absolute Bagels mysteriously closes??? A staple of my graduate student life at Columbia. Although I live over 200 miles away, I need answers.
www.nytimes.com/2024/12/12/n...
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A Bagel Shop Closes, and the Upper West Side Is Absolutely Losing It
The neighborhood reaction to the sudden, mysterious closure of a Manhattan bagel shop was intense: “No no no no no no no no no no no!!”
https://www.nytimes.com/2024/12/12/nyregion/nyc-absolute-bagels-closed.html?smid=nytcore-ios-share&referringSource=articleShare
12 months ago
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NIH’s own
@mikekrashes.bsky.social
telling it like it is.
add a skeleton here at some point
12 months ago
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There goes the neighborhood
@mikekrashes.bsky.social
is here.
about 1 year ago
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Kate Zernike and Nancy Hopkins taking questions from the crowd at NIH.
about 1 year ago
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My latest favorite idea. We are inviting friends over the day after Thanksgiving - everyone brings leftovers
about 1 year ago
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Super excited to be co-hosting scientist Nancy Hopkins and author Kate Zernike at NIH this Wednesday as part of a event jointly organized by the Porter Book Club, Women Scientists Advisors (WSA) and Women Scientist Fellows (WSF). Details:
linktr.ee/wsf.nih?utm_...
videocast.nih.gov/watch=55349
about 1 year ago
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