This paper was a tour de force and would not be possible without he help of so many collaborators like @juanbonifacino.bsky.social and many more. Thank you!!!

Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago

Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...

Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!

Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social‬ for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn

BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn

🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...

Excited to share our new review with @depaceraffa.bsky.social‬, @saikat2025.bsky.social‬, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...

Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof

New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social ‬and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...

👉 New publication ahead of print from our lab: tinyurl.com/ye7pntte We show that the protein SPG21, mutated in hereditary spastic paraplegia 21, localizes to endolysosomes via RAB7A, where it promotes mTORC1-dependent TFEB phosphorylation, reducing expression of a subset of TFEB regulated genes

me, every work week battling with the cloud.

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

Nice to meet @manorlaboratory.bsky.social in Canada and learn of his work on label-free imaging!

Happy to have made a minor contribution to this exciting study by Tasha Morrison, John O’Shea, and colleagues highlighting the key role of glycosphingolipid metabolism in natural killer and CD8⁺ T cell biology. authors.elsevier.com/c/1l0F9_278y...

Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks ! Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters. bit.ly/42jWXYD. /n

Job ad is here! Check it out :)

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!

just published onlinelibrary.wiley.com/doi/full/10....

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering

RIP my fellow "porteña" Olivia Hussey. "Born on April 17, 1951, in Buenos Aires, Olivia lived a life full of passion, love, and dedication to the arts, spirituality, and kindness towards animals." www.cnn.com/2024/12/27/e...

What are the chances I'd be in Buenos Aires just when @juanbonifacino.bsky.social is enjoying a couple of days off in his hometown? Couldn't dream of a better guide!

“Behind the Paper” commentary on our recent publication demonstrating regulation of Golgi PI4P and downstream processes by a SYS1–ARFRP1–ARL5–ARMH3–PI4KB axis go.nature.com/4fKotEg

Fantastic lecture by Svante Pääbo on archaic genomics, shedding light on human evolution and the genetic basis of diseases www.youtube.com/watch?v=tt4I... 🦴🧬

I submitted two recommendation letters today, and I'm once again begging programs to eliminate meaningless ranking metrics and simply let me upload a letter. We can collectively decide to stop wasting each other's time.

Fascinating study by Anne Simonsen's lab and colleagues reveals the role of BEACH-domain-containing proteins in cargo sorting at recycling and secretory tubular-vesicular compartments hubs.la/Q02XJ4TY0

Act now to stop millions of research papers from disappearing www.nature.com/articles/d41...

Looking forward to it!

📢 Open POST-DOCTORAL POSITION @IRBBarcelona.bsky.social in Tumour Immunology📢 ➡️ recruitment.irbbarcelona.org/jobs/5229393...

In remembrance of those lost to COVID-19, I created a Spotify playlist featuring songs by musicians who passed away from the disease: open.spotify.com/playlist/6jE.... So much beautiful humanity gone.

The world needs this cat right now.. 😊

Reposting @yousufakhan.bsky.social reference to a preprint demonstrating that programmed ribosomal frameshifting generates a PLEKHM2 proteoform that behaves as a constitutively active adaptor for ARL8-dependent coupling of lysosomes to kinesin-1, with collaboration from our lab tinyurl.com/mtrkzdrm

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

Interesting paper showing that yeast adaptor protein complex AP-3 lacks "ear" domains, and that the disordered "hinge" domains are required for budding from the late Golgi (equivalent to the mammalian TGN) journals.biologists.com/jcs/article/...

A 25-year-old woman with type 1 #diabetes started #producing her own #insulin <3 months after receiving a #transplant of reprogrammed #stem #cells. She is first person with the disease to be treated using cells that were extracted from her own body. #breakthrough? www.nature.com/articles/d41...

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.

This is very interesting and highly relevant paper to clinical genetics and rare disease researchers. I wrote the accompanying News & Views piece. Free sharing link here: rdcu.be/d0VlK

This post is about a commentary that I wrote with Xin Yong about recognition of cargo vesicles by tethering factors involved in endosomes to TGN retrograde transport.

"The evolution of animal stem cells might have involved the exaptation of a pre-existing set of transcription factors", such as Sox, from unicellular organisms rdcu.be/d0NA9

One positive aspect of moving to Bluesky @bsky.app has been discovering new users to follow, which has broadened my interests. It's refreshing to have a change of perspective from time to time.

Q: What's wrong with these plots? A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility. Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...

Thank you for the suggestion! www.phylopic.org features "free silhouette images of animals, plants, and other life forms, available for reuse under Creative Commons licenses."

A favorite place. Library of the National Academy of Sciences in Córdoba, Argentina anc-argentina.org.ar

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Happy to join @bsky.app! Looking forward to rebuilding our science community here and fostering open sharing of discoveries, ideas, resources, and peer feedback. 🦋