Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

Preparing an RNAseq experiment

Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

The things I’ve learned about drug development in the last few weeks are astounding. Our society & economy are centuries behind our science & it is devastating to think about all the parents and children who are held captive. www.statnews.com/2025/10/09/c...

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

I've once again found myself in the news for unfortunate reasons. I must be cursed, or perhaps the universe is just balanced and all the positive press I've gotten for our work just needs to counteracted with some negativity www.youtube.com/shorts/kkmYw...

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026. Deadline: 20 December 2025 https://meetings.embo.org/event/26-cytoskeleton#cytoskeleton#research#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below: gbm-online.de/de/tagungska...

For academic purposes, I generated 100 UMAPs from the same tabular raw data, I sorted them and the result looks too funny to not share it with you 😃 haesleinhuepf.github.io/BioImageAnal...

The stories in this article are a huge part of what motivated me to start studying rare disease, which is actually one of the most common diseases (~10% of people have a rare disease) These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...

Soooooo what happens to all the NIH study sections in October if the government shutdown lasts 30+ days like last time? 😬😬😬

#GEF25 the expansion microscopy community would benefit from high NA, long working distance water objectives. Who's working on these? What's out there?

I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams. open.spotify.com/episode/1rjG...

I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams. open.spotify.com/episode/1rjG...

I have recently used abranalysis (from the GitHub repo) for analysis of a couple of recent datasets and it does a very nice job once I account for the acoustic latency differences. I just had to put our data into the right intermediate format, which was a simple process. Very nice contribution!

2/2: ABRA, which can automatically analyze auditory brainstem response electrophysiology data from a broad range of mice with varying levels of hearing function/loss. New features in the open-source, free-to-use software (hosted on the San Diego Supercomputer Center!) increase usability and control.

Pleased to share updates for 2 deep learning papers: 1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.

Pleased to share updates for 2 deep learning papers: 1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.

Proud to announce that our superstar postdoc Yasmin Kassim was awarded a Schmidt AI in Science fellowship! Check out her recently updated VASCilia paper and then ponder the fact that this barely scratches the surface of what we’ve done and will be doing more of together 🙌🙌🙌

I love SciSky, great term.

Flying out of San Jose buzzing after @chanzuckerberg.bsky.social #ImagingTheFuture. Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!

SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!

DSIR A 2 decades old algorithm (Outch) co-developed by my ex-boss. More than 1 year and hundreds of sequences have been experimentally tested to valide the tool, which at the time was quite some work. biodev.cea.fr/DSIR/

SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!

Trump proposed 40% cut to NIH. Senate committee (16 GOP, 10 DEM) voted 23-3 to INCREASE NIH budget by $400M Next step is House.

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

🙌🙌🙌

WARNING WARNING WARNING #ResearchAdmini I am hearing reports of NIH Awards being issued with ~15% indirect cost rate without comment. I believe the hope is that they will be accepted with noticing this.

I'm a science journalist for @statnews.com looking to talk with folks who applied to biomedical Ph.D. programs and had offers rescinded earlier this year. What have you been up to since then? You can reach me at [email protected] or via Signal (username jwosen.27). #journorequest

🙌🙌🙌 This is such an important point that I've been making for a long time (this is why our original PSSR paper included downstream biological analyses such as segmentation, event detection, etc., and not just PSNR/SSIM metrics). Very happy to see Siân put in the hard work on formalizing this!

🔬🧠 Our paper on smart microscopy & the issue of interoperability! www.biorxiv.org/content/10.1... LONG THREAD WARNING: Smart microscopy uses real-time image analysis to automatically guide the acquisition or perturbation of the sample (closed feedback-control loop). Many applications exist:

Mass spec imaging system being installed in the Sandbox today!!!

Here you go..." Why strong mentorship was essential for my career success in science" JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors. www.nature.com/articles/d41...

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

Absolutely beautiful paper with some awesome imaging of our AC-ER probe for monitoring ER-associated actin (PMID: 32778832) 🤯

What a legacy Jim leaves. His brilliance and love of science was palpable and inspiring. He was an incredible scientist- I teach his groundbreaking work on careful measurements of mechano ion channels every year. I’ll miss him. Here is a good memory with 3rd gen @yasmeen-hamed.bsky.social.

💔💔💔

Jim Hudspeth has died 💔 I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other. May his memory be a blessing. www.ted.com/talks/jim_hu...

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

Important- if you had an illegally terminated grant that was reinstated, you might not be safe. Staff are being told that grants *may* be canceled after October 1st, 2025 if not "in line with agency priorities". POs are being muzzled and can't tell grantees directly. #NIH #NIH_funding

Update - we got ahold of them. Apparently emails were going to spam?!

So…if one out of three F32 reference letter writer disappears & fails to upload by due date, what is your recourse on that last day? Can you just find someone else to submit a letter even if they’re not on your cover letter? Feeling quite desperate and would love know options!

I am unspeakably humbled and grateful for this honor - to "wear" Goeddel's name is simply insane. I can only promise to do my best to do it justice. ONWARDS!!!

Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!

I need feedback on my application. Do I know anyone with a Sloan award or, even better, has reviewed such applications in the past?

Nature Methods is also hiring to replace me (applications close August 4th!!!) and I will do everything I can to support their next bioimaging editor (ask me anything!). springernature.wd3.myworkdayjobs.com/SpringerNatu...

If you’d like to join me on this journey, NBME is hiring!! This is a fantastically rewarding career that keeps you very much in science. springernature.wd3.myworkdayjobs.com/SpringerNatu...

This is 100% true, although I cannot speak to any times of imperfection - Rita is the ideal editor, and is in my opinion the strongest possible argument for why science as a whole benefits from edited journals (in spite of all the issues).