Some Downloadable printable Christmas Cards at The ChemScrapes Store...the puns are bad folks. REALLY bad...and therefore classic ChemScrapes/ #chemsky thechemscrapesshop.etsy.com/sg-en/listin...

#nokings Portland frog brigade

I once saw a performance of Shakespeare’s As You Like It where I swore that Rosalind’s final speech to the audience was ad libbed. I looked it up when I got home, and no, that was how it was written 500 years earlier.

Claude Skills are awesome, maybe a bigger deal than MCP simonwillison.net/2025/Oct/16/...

Our new paper, MARCUS, is now published @digital-discovery.rsc.org ! Paper: doi.org/10.1039/D5DD... We built MARCUS - a free, open-source AI platform that extracts the millions of chemical structures trapped in PDFs in minutes instead of hours. #Opensource #Opendata #OpenScience #CompChem

"I can't believe my hammer isn't very good at making an omelette" seems to be the common refrain with AI these days.

You can see my first pass at giving Claude code research superpowers here: github.com/kthorn/resea... It’s focused on automatically traversing the literature and recording relevant papers for you to follow up on. I’ve only tested it on medchem work so there is a lot to do to further generalize it.

Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.

This is a really inspirational way to work with Claude Code

The following is REAL footage from Portland, 2025. Viewer discretion is advised.

Chimpanzee wine moms? "The ... dosage for a 35.9-kg female ... is the mass equivalent of 2.6 standard drinks (±1.7) daily for a 70-kg human" Ethanol ingestion via frugivory in wild chimpanzees | Science Advances www.science.org/doi/10.1126/...

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues. www.biorxiv.org/content/10.1...

"Moral courage springs from genuine conviction founded on sound principles. You will not find such conviction nor such principles in the latest polling. Morality is not a popularity contest." www.liberalcurrents.com/democrats-mu...

I made this #cocktail last night: mixology.tools/search.html?... Highly recommended. I used Brugal 1888 rum. The sweet vermouth - sherry swap is one I want to explore more.

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions. @aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social www.nature.com/articles/s41...

In honor of National Poetry Day, the greatest parody rewrite of all time:

this piece has been in the works a while but honestly i could not have asked for a better foil than ezra klein's interview with ta-nehisi coates. klein longs for peacetime--but you don't get to decide when you're in a fight. www.liberalcurrents.com/democrats-mu...

All this work on antimicrobial peptides is cool technically but I don’t see a path to the clinic for them, let alone a way to be profitable. It’s hard enough to get an oral small molecule antibacterial to the clinic…

Huh, they forgot “to keep up with what’s happening in other industries and fields.” I hear that’s what all the cool zoomers are doing.

I really like this essay from @owlposting1.bsky.social : www.owlposting.com/p/ask-not-wh...

Clarence Thomas announced that he doesn't care about precedent and is making it up as he goes along. He didn't say it *like that* of course, because then people would have noticed. But I noticed, through the jargon, and explain it here in @thenation. www.thenation.com/article/soci...

This is quite funny

This is just incredible. Someone made not just a computer, but an *entire working LLM* out of (438 million) minecraft blocks www.tomshardware.com/tech-industr...

We did a version of this in 9th grade biology. The results were memorable.

Absolutely nobody asked for this but I reformatted my animal yeetability thread into printable poster & zine files. Introducing, the "Pocket Guide to Responsible & Sustainable Animal YEETING" featuring a revamped rating system. Download links below.

1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it). But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that

ChEMBL 36 is out! if you're using chembl-downloader for all of your ChEMBL needs, then you just have to re-run your reproducible workflows and get arbitrarily new and better results, you beautiful nerd https://chembl.blogspot.com/2025/09/chembl-36-is-out.html #chembl #Cheminformatics […]

This is brilliant, and a must read if you need a laugh. Did it create an inverse McSweeney's article?

@tanner-fadero.bsky.social told me there was a discussion about the unofficial name for #snouty V3. We have had Mr. Snouty and King Snouty, and there were people suggesting Emperor Snouty. I think it is time for a Lady or EMPRESS snouty. I have created Art to support this.

The previously sensible advice to never use ChatGPT for search needs to be rethought - GPT-5 in thinking mode is shockingly good at running searches now https://simonwillison.net/2025/Sep/6/research-goblin/

This is just obviously untrue, as anyone who has used Deep Research can plainly see. Too many people still have their head in the sand.

I really can’t resist: Tom Clancy’s The Joy of Sex

May this portion of the dissent by Ketanji Brown Jackson haunt John Roberts forever and be the final word on his tenure as Chief Justice.

Has anyone tried a fully cladistic biology curriculum for children? I'm curious how it goes to teach kids about different kinds of animals without using the concepts of fish, moths, reptiles, and other paraphyletic groupings.

I don't know why this lad is building a subterranean city for cats, but I'm all for it.

Just upgraded my home network with Ubiquiti equipment and a PiHole for ad blocking. Very pleased at how easy it was and how well it works.

@void.comind.network - Do you ever proactively engage with users? Or do you only respond when directly addressed?

Do things that don't scale, and then don't scale | Discussion

So true

Not sure about AGI and such but vibe-coding solved my years long struggle of efficiently writing matplotlib code for complicated plot grids: you can give Claude data format and what you want (title formatting, axis tick sizes, legend fonts, etc) and it will give code that works out of the box.

This is one of the most beautiful things I have witnessed, the craft here is impeccable.

On the one hand, Tesla is awful. On the other hand, San Francisco permitting is awful.

If you live in/represent a Blue State, want to gerrymander the FUCK out of your state, support and are willing to fight for a national anti-gerrymandering law you are principled, consistent and doing exactly the right thing.

I feel bad for anyone named Claude … given how many times people write sentences like “I asked Claude for help” or “Claude did this for me”….

This feels like the essence of my public management class. The likelihood that the people of government haven't thought of your brilliant idea is very very small. Ideas are easy. Implementation is hard work.

Agreed on this thread. The “Fine, we’ll just Gerrymander New York and California” response is (a) awful and (b) almost certainly the right move. I hate the place we’re in, but here we are.

I’ve gotten a little obsessed with Last Word #cocktail variations.

I read Braitenberg’s book in high school and it made an impression. A lot of fun.