What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs

Let us go then, you and I, When the evening is spread out against the sky Like a patient etherized upon a table

One of my great regrets from my academic work is that I never got to do a mucus microrheology study I discussed with an MD.

Fig. 7: Real biology

I use ChatGPT5.1 Thinking for a lot of questions both at work and personally - with web search, it’s very good at searching the scientific literature. Lately , I’ve realized not only is it useful, I like its tone and personality. For example:

who decided to call it Secret Santa when Nondisclosure Claus was right there

I loved Arcadia, but I think my favorite is Coast of Utopia. I remember being blown away by part 2 when I saw it on Broadway

Sad news. Tom Stoppard was one of the greats.

I love the JBB story for a few reasons: - stringing 120 miles of wire - months of analzying paper roll data - her PI was like "that can't be right, do it again," the motto of PI's everywhere. - rare case of a landmark discovery becoming ubiquitous in popular culture for no particular reason

Audience culture is the worst it's ever been, I swear to god. People forgot how to act. I'm at the theater, trying to enjoy my show, which I've paid GOOD MONEY for, and these two old assholes are in the balcony heckling the life out of the poor bear onstage. Not letting him finish a single joke.

This is an insightful but deeply upsetting article about why everyone in the US feels poor, and why the current political situation emerges as a direct result. www.yesigiveafig.com/p/part-1-my-...

I can’t find the cyber truck one but it’s hardly alone

Bottom part of your rocket coming detached from the top part? Problematic stage gap

First, assume a spherical robin…

This result is crazy. You finetune a teacher model to love owls. Then you have the teacher model generate a string of numbers, and finetune the student model on those numbers. The student model will then also love owls. alignment.anthropic.com/2025/sublimi...

Well it's time to check out what's happening on my social media feeds OH DEAR GOD NO

people are actually very susceptible to just-so stories about human origins because listening to bullshit helped us survive on the savanna

Some of the art posted on this account reminds me very strongly of a book or books I had as a child but cannot remember.

ryan is right. people HATE hearing this. but it is just a matter of simple incentives. if you want a more representative legislature — and if you want a legislature more resistant to corruption — then you need to jack up the salaries. serving as mayor of NYC should net you a cool 500K *at least*

Has Claude Code gotten cheaper recently? I spent a lot on it last month, and now I find myself doing fairly complex refactors with it and only spending like $3.

Every image this account posts would have sold me a paperback book in the 1980s. I would have been unable to resist these covers.

I feel like this headline sums up everything wrong with American policy: www.nytimes.com/2025/11/03/h...

Oh my! the reviewer and editor comments 😜😂

When I was a kid, a family I knew went as Mark (Karl) and Lenin and Marx Groucho) and Lennon.

I agree with this analysis and it aligns with how we’ve been working at ArrePath.

I’ve been having pretty good luck using agents for data wrangling - downloading excel and sd files from supplementary material and having the agent help parse and clean the data by asking it questions about the data. Saves me writing a lot of boilerplate pandas code.

I once went snorkeling in the Caribbean as pelicans dove around me to eat fish. It was very cool.

I am the very model of an ancient trunkless leg of stone, My shattered visage lies half buried with a sandy sneering frown, The sculptor carved my arrogance upon these broken lifeless things, My name is Ozymandias, the self-describèd King of Kings!

We are introducing a very early research preview of Letta Code. Letta Code is our solution to the terminal-based coding assistant, but with state and learning built in. No more compactions. Just specialist agents that learn your code with every commit.

A sad consequence of this is that much academic software is unmaintained, so many useful tools require, for example, obsolete python versions to use.

The irony in this is that the guardrails do absolutely nothing when bad actors are elected (see the current administration).

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

This is beautiful

I really think that we need to talk more about the fact that Republicans have basically quietly abolished the House of Representatives

The German company that makes the mechanical ladder used in the Louvre heist has used the image to advertise, with the text 'When you need to move fast' 10/10 response, no notes

Achira is growing! We’re looking for talented software engineers, ML research engineers, and AI/ML scientists to join our team in building foundation simulation models to power the future of drug discovery. Apply at achira.ai

if disney does a theatrical release of the original star wars films for the 50th anniversary and offers them on physical media i will forgive them for every terrible decision they've made with star wars

I've just released the first version of a new Claude Code plugin that helps it remember what it was doing yesterday, why it changed direction, and every conversation it has with you. blog.fsck.com/2025/10/23/e...

Does anyone else think it’s possible that the government shutdown never actually ends?

No, your study section will not meet during the shutdown. No, your grant will not be reviewed during a shutdown. No, POs, SROs, and everyone else in NIH/NSF is not allowed to contact you so stop expecting a "heads up." The government shutdown is your "heads up."

I am very concerned about this, and I think the effects will be felt sooner than 3-5 years.

Whoa:

Some Downloadable printable Christmas Cards at The ChemScrapes Store...the puns are bad folks. REALLY bad...and therefore classic ChemScrapes/ #chemsky thechemscrapesshop.etsy.com/sg-en/listin...

#nokings Portland frog brigade

I once saw a performance of Shakespeare’s As You Like It where I swore that Rosalind’s final speech to the audience was ad libbed. I looked it up when I got home, and no, that was how it was written 500 years earlier.

Claude Skills are awesome, maybe a bigger deal than MCP simonwillison.net/2025/Oct/16/...

Our new paper, MARCUS, is now published @digital-discovery.rsc.org ! Paper: doi.org/10.1039/D5DD... We built MARCUS - a free, open-source AI platform that extracts the millions of chemical structures trapped in PDFs in minutes instead of hours. #Opensource #Opendata #OpenScience #CompChem

You can see my first pass at giving Claude code research superpowers here: github.com/kthorn/resea... It’s focused on automatically traversing the literature and recording relevant papers for you to follow up on. I’ve only tested it on medchem work so there is a lot to do to further generalize it.