Online now! Online now! Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock #chembiol

Online now! Online now! De novo design of Ras isoform selective binders #chembiol

The March issue of Cell Chemical Biology is now online! Explore the latest research, reviews, and insights in chemical biology. Check it out here: http://dlvr.it/TRb66p

The November issue of Cell Chemical Biology is live! Click here to read: www.cell.com/issue/S2451-...

Online now! Online now! TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics #chembiol

Online now! STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency #chembiol

Check out our collection ‪@cp-cellchembiol.bsky.social‬ on molecular mechanism of host-microbiome interaction

Online now! Online now! Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression #chembiol

@cp-cellchembiol.bsky.social is now on LinkendIn! Please follow us here: www.linkedin.com/company/1069...

With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids www.nature.com/articles/s41...

Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches by Yi Rao and colleagues at @PKU1898, @chinese_brain, Peking-Tsinghua Center for Life Sciences http://dlvr.it/THQXFd

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain by Sidharth S. Madhavan, John Newman @GeriSciDoc, et al at @BuckInstitute @USC @USCLeonardDavis @UCSF @IthacaCollege http://dlvr.it/THQZnx

#Technology Degradome analysis to identify direct protein substrates of small-molecule degraders by @Ma_Jochem, @Krijgsveld_lab, and colleagues at @DKFZ @CeMM_News @UniHeidelberg http://dlvr.it/THQcwD

Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch http://dlvr.it/THQfvX

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al. at @Cambridge_Uni http://dlvr.it/THYqLx

Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org

Interesting talk by Paul Hensbergen from the LUMC at #NPP2025. He talked about his work in collaboration with the @smitslab.bsky.social on studying Clostridioides difficile with (glyco)proteomics. Exciting insights into glyosylation of the flagellum. pubs.acs.org/doi/10.1021/...

Read this insightful Voices where @judith-behnsen.bsky.social and others share their perspectives on how advances in chemical biology approaches provide new opportunities for mechanistic and functional investigation of the microbiome. www.cell.com/cell-chemica...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social www.cell.com/cell-chemica...

Read @cp-cellchembiol.bsky.social 's latest Focus Issue on Chemical Biology of the Microbiome here: www.cell.com/issue/S2451-...

Online now! Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders by @jtang162, @DanHarki, and colleagues at @UMN_MedChem @UMNews @UTHealthSA @HHMINEWS @UCSanDiego http://dlvr.it/THDH9Z

Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW

An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it). Also features G.K. Chesterton and a brief cameo by RFK Jr.

DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:

Thank you @mishtudey.bsky.social and the other organizers for a fantastic symposium. The talks covered broad areas of chemical biology-from targeted protein degradation and molecular glues to sensor development and immuno-oncology. They also represented a nice blend of academic and industry efforts.

Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1: go.bsky.app/3P5i7nJ V2: go.bsky.app/Cr4ej7

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

It was a great pleasure to present @CellSymposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!! Thanks to the organisers for this opportunity! @mariesorbara.bsky.social

🔈🔥! We have two open full professor positions at our institute (LOC) at ETH Zurich! 1. Synthetic Organic Chemistry 2. (Bio)analytical Chemistry Amazing students, staff, colleagues, infrastructure, location and long-term perspectives. 🫵 Apply and be our colleague!! ethz.ch/en/the-eth-z...

Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up: grc.org/bioorganic-c...

Online now! Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release by Madoka Ono, Masatoshi Hagiwara, and colleagues at @KyotoU_News @univkyoto http://dlvr.it/TGbCl1

Incredible meeting #CSChemBio2024 in San Francisco including talks from @fleurmferguson.bsky.social, @danetteldaniels.bsky.social, Michelle Arkin, Ingrid Wertz, and @mishtudey.bsky.social!

Want to start your own lab out of grad school? Arc’s Science Fellows receive funding for a team of 2-4 people! Applications due Jan 15 from new-career scientists in Neurobiology or Immunology. Join Arc co-founder Patrick Hsu for an info session Fri 12/6 10 am PST. Register here: shorturl.at/r1cgD

First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.

We are here now! ☺️

So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer! www.nature.com/articles/s43...

Online! β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain by Sidharth Madhavan, John Newman @GeriSciDoc, et al at @BuckInstitute @USCLeonardDavis @UCSFGeriatrics @IthacaCollege http://dlvr.it/TGXk7s

Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by H. Bailey, J. Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 et al at @goetheuni @IBC2_GU @MPIBP @merckgroup http://dlvr.it/TGRD4Y

Grateful to @berkeleyMCB for highlighting our lab and our recent discoveries! It was fun to discuss some of the surprises during our research on lipid homeostasis, lipid droplets, & ferroptosis—driven by exceptional UC Berkeley students & postdocs. mcb.berkeley.edu/news-and-eve...

sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...

Awesome a16z bio and health podcast with Jorge Conde and @carolynbertozzi.bsky.social : a16z.com/podcast/bioo...

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ

Online now! Degradome analysis to identify direct protein substrates of small-molecule degraders by @Ma_Jochem, @Krijgsveld_lab, and colleagues at @DKFZ @CeMM_News @UniHeidelberg http://dlvr.it/TG896J

Seems like this time, the move to Bluesky may not just be a blip! Reposting a paper we published earlier this year that sheds light on certain forms of cancer-induced autoimmune neurological disorders. 🧪 #neurosky www.sciencedirect.com/science/arti...

@cellchembiol.bsky.social is here as well and so am I. Please follow us here

Follow @cellchembiol.bsky.social here

Meet the Authors Q&A with @LydiaTsams and @DBachovchin. Read for more insights on their paper in this issue and their lives as scientists. http://dlvr.it/TDRp3T

Voices: @CKadoch, @JSheltzer, and Hang Yin tell us which topic they think will win the next Nobel Prize in Chemistry or in Physiology or Medicine. http://dlvr.it/TDRdnk

#Featured Voices: @MichelleArkin, Sara Buhrlage, Ling-Ling Chen, Peng Chen, @GestwickiJason, Chuan He, Gerald Joyce, Angela Koehler, @MilkaKostic, Jun Liu, @realJimWells on CCB and chemical biology. http://dlvr.it/TDRfDJ