Processing of Reversed Replication Forks is Required for the Resolution of Replication-Transcription Conflicts www.biorxiv.org/content/10.6...

Full article: Genomic evolution and re-emergence of a multidrug-resistant Clostridioides difficile RT027 clone with reduced vancomycin susceptibility driving a prolonged hospital outbreak www.tandfonline.com/doi/10.1080/...

Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense - Shafqat - 2026 - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....

Am stoked and thrilled that our latest paper is now out. A longitudinal study of invasive E. coli from children in the Netherlands over 50 years www.sciencedirect.com/science/arti...

Our recent work is now available in bioRXIV!

(bacterial) chromosome segregationists take note 👇 membrane-anchoring of the 𝘰𝘳𝘪𝘊 region to ensure proper daughter chromosome segregation after replication initiation – proposed decades ago but never substantiated... 👉now shown for 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 by mariana pinho's lab

Microbial #dysbiosis alters chemical cues in the oral #microbiome, but how do commensals sense these? This study shows that #Streptococcus salivarius detects dysbiosis metabolites & repurposes a peptide #QuorumSensing receptor to drive antibacterial predation @plosbiology.org 🧪 plos.io/4rtVSbf

Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile www.biorxiv.org/content/10.6...

🚨 New paper! Very excited to have been part of this collaborative work looking at the effect of antibiotics on the gut microbiota even years after prescription. Amazing effort led by Gabriel @tovefall.bsky.social and many others published today in Nature Medicine! 🔗 www.nature.com/articles/s41...

Why some #gut #microbes persist after #fecal #transplants ... | #Bacteria | #microbiota | #MicroSky | #poop | By @kingscollegelondon.bsky.social via @sciencex.bsky.social

How can we tap into the enormous functional diversity of microbes on this planet? Join us at EMBL Heidelberg (8–10 Dec 2026) to learn about ongoing efforts to decode gene function and organisation in human gut microbes, and present your science.

#Virus hiding inside #bacteria may help explain #colorectal #cancer ... | #Bacteroides | #microbiome | #bacteriophages | #phage | Via @sciencex.bsky.social

This is so cool: www.biorxiv.org/content/10.6... Discovery of a Genetic Toxin-Antidote System in Vertebrates hat tip to @asaflevylab.bsky.social

Paper 🚨: in this Narrative Review we describe the challenges and opportunity of a microbiome research facility, based on our experiences at LUMC with Center for Microbiome Analyses and Therapeutics (CMAT) www.sciencedirect.com/science/arti... #ESGHAMI @escmid.bsky.social @cmijournal.bsky.social

After >10 years of our lab studying bacterial cGAS-like enzymes, @hobbslabutah.bsky.social finally reconstitutes viral sensing in vitro and discovers how these ancient receptors sense phage protease enzymes to detect virion assembly and activate antiviral immunity www.biorxiv.org/content/10.6...

🚨Publication alert! In this manuscript we describe the characterization of the non-toxigenic C. difficile (#NTCD) strain L-NTCD03 that we have used in our controlled human colonization experiments. academic.oup.com/femsmicrobes...

📢Publication alert: Clinical prevalence of collateral sensitivity: a systematic exploration of multicentre antimicrobial surveillance data 💊wonderful work from Coen van Hasselt's lab, with a minor contribution from yours truly - www.sciencedirect.com/science/arti...

Finally out in @natmicrobiol.nature.com: Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Great work by @stephkoe.bsky.social @kassipan.bsky.social @jvhooff.bsky.social www.nature.com/articles/s41...

A Potent Quinone Reductase Encoded by ywqN (Qnr1) Protects Bacillus subtilis from Oxygen Radical Genotoxicity www.mdpi.com/3733756 #mdpimolecules via @Molecules_MDPI

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Nature research paper: Convergent MurJ flippase inhibition by phage lysis proteins go.nature.com/4aAWHKb

Clonal relatedness and emerging linezolid resistance in Clostridioides difficile ribotypes 001 and 176 in the Czech Republichttps://www.sciencedirect.com/science/article/pii/S1201971226000792

A protein adaptor mediating Ap4A-dependent control of protein acetylation www.nature.com/articles/s41... #diadenosinetetraphosphate

Aerocavin is an antibiotic with potent and specific anti-Neisserial activity www.biorxiv.org/content/10.6...

Mechanistic basis of teichoic acid transport by a gatekeeper flippase www.biorxiv.org/content/10.6...

Relaxase Asymmetry Drives Initiation of Bacterial Conjugation www.biorxiv.org/content/10.6...

Genome size and nucleotide skews as predictors of bacterial growth rate www.biorxiv.org/content/10.1...

A single dose of the psychedelic drug dimethyltryptamine (DMT), given with psychological support, rapidly reduced depressive symptoms in 34 adults with major depressive disorder, according to a clinical trial published in Nature Medicine. 🧪#mentalhealthsci

New preprint: Identification of novel cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile www.biorxiv.org/content/10.6...

The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination dx.plos.org/10.1371/jour...

Excited that our article is out in @cmijournal.bsky.social this month: A roadmap to clinical translation of #microbiome research 🦠🧫 Check it out now: 10.1016/j.cmi.2026.01.021

Preprint on the permeability of Gram+ bacterial cell wall from a few months ago. Intriguing findings, elegant methodology. Cell wall is largely impermeable to molecule sizes of mNeonGreen (27kDa) and above. How do larger secreted proteins get through? www.biorxiv.org/content/10.1... #microsky

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist? Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

The emergence and biological characteristics of linezolid-resistant Clostridioides difficile isolates in the Asia-Pacific Region www.tandfonline.com/doi/full/10....

Phase 1 and preclinical studies reveal safety, pharmacokinetics, and efficacy of intranasal delivery of the influenza antibody CR9114 | Science Translational Medicine www.science.org/doi/10.1126/...

Commensal human gut microbes produce species specific neuroactive compounds - www.sciencedirect.com/science/arti...

New Preprint 📢 from our team 🔎 Critical assessment of #intratumor and #low #biomass #microbiome using #longread sequencing Some studies suggest bacteria 🦠 live inside tumors and influence cancer treatment. But there’s also been a major #debate: in these very​ low-microbe tissue samples, how much 1/

rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

BackToBack #PhageSky in @nature.com A pore-forming antiphage defence is activated by oligomeric phage proteins -from Maxwell & Norris www.nature.com/articles/s41... Bacterial immune activation via supramolecular assembly with phage triggers -from Laub & Ghanbarpour www.nature.com/articles/s41...

Parallel tracking by sequencing reveals the impact of restriction modification systems on transfer of an integrative and conjugative element www.biorxiv.org/content/10.6...

🦠🧬🖥️ Bakta v1.12.0 is out with tons of tiny improvements and bug fixes, too many to list all: - partial genes on linear seqs - improved errror handlings & runtimes - support Python 3.12 & 3.13 - ... A huge shout out and thank you to all bug reporters and contributors! github.com/oschwengers/...

Ziplign published in JOSS. Tool to easily interactively compare two bacteria genomes. Inspired by ACT, but easier to install and use. Drag and drop files, or download using accessions. It runs blast for you. No terminal needed. github.com/martinghunt/...

Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era - www.nature.com/articles/s41...

Dynamic DnaA–DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication url: academic.oup.com/nar/article/...

Wow. Journals like this should be immediately removed from the Clarivate database.

Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage www.nature.com/articles/s41...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

Fast-growing trees are set to dominate the #forests of the #future — but at a cost🌳 Our Nature Plants (@natplants.nature.com) study shows a global shift toward "sprinter" tree species, while slow-growing, functionally critical #trees face elevated #extinction risk. www.nature.com/articles/s41...