🧪Thrilled to share our new study "The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice” in PLoS Pathogens! @bordenlacy.bsky.social ➡️We show that this mAb alone protects against infection with strains encoding TcdB variants. 1/20

Impact of Hanks Kinase-Dependent Phosphorylation of CodY on the Physiology and Virulence in Bacillus cereus - onlinelibrary.wiley.com/doi/10.1002/...

Essential and dispensable domains of DivIVA for walled growth in filamentous Actinomycetota | Open Biology royalsocietypublishing.org/doi/10.1098/...

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria doi.org/10.1099/mic.... b @winterhalterlab.bsky.social @heathmurraylab.bsky.social et al.

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...

To all visionary microbe enthusiasts: @femsmicro.org is looking for an editor-in-chief for their flagship journal FEMS Microbiology Reviews! More details can be found here: fems-microbiology.org/opportunitie...

🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...

Bacteria sense virus-induced genome degradation via methylated mononucleotides www.biorxiv.org/content/10.1...

The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts www.nature.com/articles/d41...

Now online! journals.plos.org/plospathogen... #MicroSky

HT Ed Kuijper: a rise in "Letters to the Editor" generated with AI. A potentially big problem! www.nytimes.com/2025/11/04/s...

Acquired Resistance during Short-Course Treatment for Rifampicin-Resistant Tuberculosis - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.org/article/S119...

So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...

New paper alert! 🚨Work led by Jan Franzen from Horst Posthaus' lab, who spent some time in our group. Amazing collection of C. perfringens isolates, 220 new @pacbio.bsky.social genomes + analyses. doi.org/10.1099/mgen...

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Our new Nature Chemistry paper is also accompanied by an insightful News and Views article by @jeyunjo.bsky.social and @mbogyo.bsky.social. Check it out here: www.nature.com/articles/s41... Thank you very much for the kind comments on our work!

Cool 🦠 William Schmidt Gerard Wong Lab @UCLA Nature Microbiology Pseudomonas aeruginosa lays down Psl exopolysaccharide as it crawls Other cells detect and follow these trails using type IV pili pulling against adhesins like CdrA triggering c-di-GMP & cAMP surges to shift into early biofilm mode

Analysis of essential genes in Clostridioides difficile by CRISPRi and Tn-seq | Journal of Bacteriology journals.asm.org/doi/10.1128/...

Characterization of two co-regulated response regulators in Clostridioides difficile | Journal of Bacteriology journals.asm.org/doi/10.1128/...

Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...

Interesting paper 'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019' TL;DR: - dramatic falls in MRSA - pneumococcal resistance rates low - E. faecium more prevalent (and more vanR) than E. faecalis pubmed.ncbi.nlm.nih.gov/41140273/

🚨Paper alert! DNA reference reagents isolate biases in microbiome profiling: a global multi-lab study | mSystems journals.asm.org/doi/10.1128/...

DNA reference reagents isolate biases in microbiome profiling: a global multi-lab study | mSystems journals.asm.org/doi/10.1128/...

This is so cool.

Many antiphage systems use NAD+, in many ways. @hugovaysset.bsky.social reviewed them all! Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity! www.cell.com/molecular-ce...

We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures. Join our speakers & register today! ➡️https://bit.ly/47rtkbw #ProkaryoticCellBio

Very excited to share the latest work from our lab, which was published today in Nature! nature.com/articles/s41... PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

Genome-wide DNA bridging by H-NS reshapes the stationary phase nucleoid and transcriptional landscape www.biorxiv.org/content/10.1...

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out: www.nature.com/articles/s41... Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...

New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...

New preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...

New online! Clostridioides difficile pathogenesis and control

They’re coming y’all…the megaplasmids are coming (I say this in a slightly frustrated manner as someone who has been thoroughly unsuccessful in getting funding to study megaplasmids for the better part of 15 years)

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

Wildlife advocate and primate expert Jane Goodall dies at 91 - www.reuters.com/business/env...

What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen: www.microbiologyresearch.org/content/jour...

Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation | PNAS www.pnas.org/doi/10.1073/...

Our own @alexjprobst.bsky.social @geomicrosoares.bsky.social and Cristina Moraru have recently authored a @natmicrobiol.nature.com Consensus Statement where they discuss new mechanisms for sequencing data reuse! 🧬💻 Check out their manuscript here: www.nature.com/articles/s41...

The emerging view on the roles of butyrate in Clostridioides difficile pathogenesis | Infection and Immunity journals.asm.org/doi/10.1128/...

De novo design of potent inhibitors of clostridial family toxins | PNAS www.pnas.org/doi/10.1073/...

The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin www.biorxiv.org/content/10.1...

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV www.biorxiv.org/content/10.1...

Wearing #red today in honour of #worldheartday - raising awareness for #CVD.

Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n

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