Jörg Stülke
@joergstuelke.bsky.social
📤 251
📥 146
📝 88
News on the control of metabolism in Bacillus subtilis:
#SubtiWiki
www.sciencedirect.com/science/arti...
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Discovery of new mechanisms to control metabolism and homeostasis in Bacillus subtilis
Biosynthetic needs of a cell and the generation of precursors and energy in catabolic reactions must be faithfully balanced. Even in model organisms s…
https://www.sciencedirect.com/science/article/pii/S1369527426000597?via%3Dihub
3 days ago
0
2
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Hot off the press: insights into the role of the Y-complex in modulating RNA degradation in Bacillus subtilis
#SubtiWiki
www.nature.com/articles/s41...
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Stress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex - Nature Communications
Transcriptional regulation is a central mechanism underlying bacterial adaptation to stress. Here, the authors used a genetic fitness screen to show that the Y-complex in Bacillus subtilis contributes...
https://www.nature.com/articles/s41467-026-73310-x
4 days ago
1
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5
Did you always wonder about the miraculous role of RNase J2 in B. subtilis? Here comes the answer!
#SubtiWiki
www.biorxiv.org/content/bior...
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https://www.biorxiv.org/content/biorxiv/early/2026/05/29/2026.05.27.728192.full.pdf
5 days ago
0
4
1
The
#SubtiWiki
Paper of the Month for April 2026 has been selected! Congratulations, Fabian Commichau
@molmicrounihoh.bsky.social
and all involved!
journals.asm.org/doi/10.1128/...
10 days ago
0
2
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Read the new article of
@c-elfmann.bsky.social
on
#SubtiWiki
(sorry, in German)!
link.springer.com/article/10.1...
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Von der Bioinformatik ins Labor und zurück: das neue SubtiWiki - BIOspektrum
BIOspektrum -
https://link.springer.com/article/10.1007/s12268-026-2723-x
21 days ago
0
4
2
Good evening from Nürnberg
23 days ago
0
2
0
I am happy to share that SubtInfluencer
@c-elfmann.bsky.social
has received the Ph.D. Award of the
@vaam-microbes.bsky.social
! Congratulations, Christoph!
@imprsgs.bsky.social
@uni-goettingen.de
#SubtiWiki
2 months ago
4
11
2
Morning sky in Göttingen, good morning!
3 months ago
0
2
1
Important new discovery: AsnS controls replication restart from DNA:RNA hybrids! Houra Merrikh lab
#SubtiWiki
@biorxiv-microbiol.bsky.social
@heyzajr.bsky.social
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.26.708313v1
3 months ago
0
3
0
Yesterday,
@jeaninerismondo.bsky.social
finished the final act of her habilitation. Congratulations, Jeanine and welcome as recognized academic teacher! Even our Dean chose his most festive outfit 🥹!
@uni-goettingen.de
3 months ago
1
8
1
The
#SubtiWiki
paper of the month for February has been chosen. It reports about AppppA-mediated control of protein acetylation. Congrats to the groups of
@bangebalcony.bsky.social
and collaborstors!
subtiwiki.uni-goettingen.de/wiki/index.p...
3 months ago
2
7
1
From now on, the
#SubtiWiki
interaction widget also includes interactions that involve RNA molecules (with proteins, metabolites, or other RNAs)! Please contact us if you miss any RNA interaction in B. subtilis!
4 months ago
0
3
1
The
#SubtiWiki
paper of the month for February has been selected. Great work on the final phase of cell division.
subtiwiki.uni-goettingen.de/wiki/index.p...
4 months ago
0
3
2
Gewinner des Tages der
#Bild-Zeitung
ist heute die Mikrobe des Jahres der
@vaam-microbes.bsky.social
, Penicillium!
#moty
6 months ago
0
5
3
Our team wishes you a Merry Christmas and all the best for the new year!
@uni-goettingen.de
#Subtiwiki
6 months ago
1
4
0
New in
#SubtiWiki
: Clusters of structural homologs! Enjoy the new feature! Thank you, Oskar Geissel &
@c-elfmann.bsky.social
@uni-goettingen.de
@imprsgs.bsky.social
6 months ago
1
12
6
Cool new paper on the structure and possible function of the type VII ABC transporter YtrEF in cell wall remodeling in Bacillus subtilis!
#SubtiWiki
www.sciencedirect.com/science/arti...
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Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics
Bacteria utilize a variety of mechanisms to remodel the cell wall in response to environmental and antimicrobial stress. In the model organism Bacillu…
https://www.sciencedirect.com/science/article/pii/S0969212625003910
7 months ago
0
9
2
Yesterday, we had the graduation ceremony and PhD party of
@c-elfmann.bsky.social
.
@uni-goettingen.de
@imprsgs.bsky.social
#SubtiWiki
8 months ago
0
4
1
Today
@c-elfmann.bsky.social
, the mastermind of
#SubtiWiki
successfully defended his PhD thesis! The 50. PhD graduate from the group! Congratulations, Christoph!
@uni-goettingen.de
@imprsgs.bsky.social
8 months ago
4
15
1
We have started to add references to the
#SubtiWiki
metabolite pages. Please leg us know if your paper/ metabolite is missing!
@c-elfmann.bsky.social
@imprsgs.bsky.social
@johnhelmann.bsky.social
8 months ago
0
6
1
Sneak preview of the next upcoming
#SubtiWiki
feature: All proteins are assigned to clusters sharing similar structures! Brought to you by Oskar Geissel and
@c-elfmann.bsky.social
.
@imprsgs.bsky.social
8 months ago
1
6
2
Identification of genetic interactions in Bacillus subtilis cell division. Congratulations, Byoung-Mo Koo, Carol Gross, and all involved!
@cp-cellsystems.bsky.social
#subtiwiki
www.cell.com/cell-systems...
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Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi
Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...
https://www.cell.com/cell-systems/fulltext/S2405-4712%2825%2900239-X
8 months ago
0
15
8
Bye bye Binz! It’s really hard to leave Rügen on such a fantastic morning
8 months ago
0
3
0
Impressions from a weekend at the Baltic Sea coast: Stralsund, Binz, Sellin, Cap Arkona
8 months ago
0
2
0
Very much looking fo to the PhD defense of the brain behind
#SubtiWiki
,
@c-elfmann.bsky.social
. It will take place on October 17 at 2 pm.
@imprsgs.bsky.social
9 months ago
1
7
0
Read a Limerick on B. subtilis on the
#SubtiWiki
homepage! Source: The Omnificent English Dictionary in Limerick Form (
oedilf.com
)!
9 months ago
0
2
1
reposted by
Jörg Stülke
Michael Galperin
9 months ago
Some thoughts on metabolism and metabolic pathway holes (PMID: 40892933)
pnas.org/doi/10.1073/...
.
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Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS
Using bioinformatics for identifying and plugging metabolic pathway holes
http://pnas.org/doi/10.1073/pnas.2518071122
0
12
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The
#SubtiWiki
Paper of the month for August 2025 has been selected. Congratulations, Marianne Broc,
@axelmagalon.bsky.social
and all involved!
pubmed.ncbi.nlm.nih.gov/40855134/
9 months ago
0
1
0
Discovery of a novel membrane plugin that links formate and NAHD dehydrogenases to the quinone pool for respiration! Work by Marianne Brock et al.,
@axelmagalon.bsky.social
and Anne Walburger lab @
@univ-amu.fr
www.nature.com/articles/s41...
#SubtiWiki
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A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases - Nature Structural & Molecular Biology
Here, the authors describe a tubular module connecting oxidoreductases to the membrane. This system, found in many microorganisms, reveals a distinct mode of membrane anchoring and an electron transfe...
https://www.nature.com/articles/s41594-025-01607-4
9 months ago
0
3
2
Professorship in Microbial Genetics @ University of Göttingen. Don't miss this chance to become my colleague!
uni-goettingen.de/en/699057.html
#SubtiWiki
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W1-TT-W2 Microbial Genetics - Georg-August-University Göttingen
Website of the Georg-August-University Göttingen
https://uni-goettingen.de/en/699057.html
10 months ago
0
19
29
New cool work from French friends and colleagues: identification of Rho termination sites in B. subtilis!
academic.oup.com/nar/article/...
#SubtiWiki
@narjournal.bsky.social
@inrae-france.bsky.social
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Comprehensive mapping of transcription terminator Rho utilization (Rut) sites across the Bacillus subtilis genome
Abstract. Recent evidence indicates that the bacterial Rho helicase regulates Bacillus subtilis gene expression in a growth-dependent manner. This regulati
https://academic.oup.com/nar/article/53/15/gkaf765/8234004
10 months ago
0
14
11
The
#SubtiWiki
paper of the month for July has been chosen! Cool work from Paris!
www.nature.com/articles/s41...
10 months ago
0
0
2
Metals are essential for life, but they can also be toxic. Here,
@johnhelmann.bsky.social
gives an excellent overview on bacterial metal physiology!
@natrevmicro.nature.com
#SubtiWiki
www.nature.com/articles/s41...
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Microbial metal physiology: ions to ecosystems - Nature Reviews Microbiology
Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review, Helmann discusses the key chemical con...
https://www.nature.com/articles/s41579-025-01213-7
11 months ago
0
15
4
Hello from the impressive Grundtvig’s church in Copenhagen!
11 months ago
0
2
0
News on the mechanisms of lateral peptidoglycan growth in Bacillus subtilis! @natcomms.nature.com
#SubtiWiki
11 months ago
0
0
0
Good evening from Göttingen! This car, a more than 35 year old Trabant made of plastic material, was next to mine at the petrol station this afternoon. I earned my driver‘s licence on a Trabant back in 1982!
11 months ago
0
1
0
Absolutely amazing paper from the lab of Carol Gross! So inspiring!
@biorxiv-microbiol.bsky.social
#mycoplasma
#subtiwiki
www.biorxiv.org/content/10.1...
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Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3
Accurate prediction of protein complex structures by AlphaFold3 and similar programs has been successfully used to predict the presence of protein-protein interactions (PPIs), but this technique has n...
https://www.biorxiv.org/content/10.1101/2025.07.01.662654v1
11 months ago
1
8
4
Great paper on the function of SpoIIIL! Congrats to
@crodrigueslab.bsky.social
@plos.org
#SubtiWiki
journals.plos.org/plosgenetics...
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SpoIIIL is a forespore factor required for efficient cell-cell signalling during Bacillus subtilis sporulation
Author summary Bacterial endospores allow bacteria to survive stress, persist in the environment and seed new and recurring infections. Cell-cell signalling is a cornerstone of how bacteria develop in...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011768
11 months ago
1
2
1
The
#SubtiWiki
Paper of the month for June 2025 has been selected. Congratulations,
@apbrogan.bsky.social
@
@harvardmed.bsky.social
@natmicrobiol.nature.com
subtiwiki.uni-goettingen.de/wiki/index.p...
11 months ago
0
6
3
Really proud and grateful that lab members (current and former) have received poster and presentation awards! Congratulations, Javi and Robert
@warneke.bsky.social
!
@uni-goettingen.de
@imprsgs.bsky.social
#subtiwiki
12 months ago
1
5
0
Don't miss the 1st Symposium on Interconnections of Gene Expression Processes this September in Göttingen! Great lineup of speakers and plenty of chances for ECRs to present & discuss their work! Link:
sfb1565.uni-goettingen.de/symposion/
@rnasociety.bsky.social
@uni-goettingen.de
#subtiwiki
12 months ago
0
3
3
@apbrogan.bsky.social
et al. show how the CdaR protein senses cell envelope defects and activates CdaA to synthesize the seccond messenger c-di-AMP in Bacillus subtilis. The increase in c-di-AMP reduces turgor and protects the cell from lysis. Congratulations!
#subtiwiki
rdcu.be/ermFn
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Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis
Nature Microbiology - Brogan et al. uncover a signalling pathway in which levels of the nucleotide second messenger c-di-AMP increase in response to defects in cell wall synthesis. This regulatory...
https://rdcu.be/ermFn
12 months ago
2
9
2
Shakespeare adapted to Bacillus subtilis 🥹
@annualreviews.bsky.social
#SubtiWiki
www.annualreviews.org/content/jour...
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To Sporulate or Not to Sporulate: Developmental Checkpoints Monitoring Bacillus subtilis Sporulation | Annual Reviews
Developmental processes are carefully regulated programs that are present in multiple kingdoms of life and that generally result in cell differentiation and specialization. This regulation can be medi...
https://www.annualreviews.org/content/journals/10.1146/annurev-micro-041522-103140?utm_campaign=shareaholic&utm_medium=bluesky&utm_source=socialnetwork
12 months ago
0
3
2
reposted by
Jörg Stülke
Biology OA
about 1 year ago
AlphaFold predictions accelerate protein structure determination but require experimental validation. Many align with crystallographic maps, but discrepancies occur, highlighting the importance of confidence assessment & verification for accurate structural insights.
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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
https://doi.org/10.1038/s41592-023-02087-4
0
15
6
All metabolites have now been assigned to categories in
#SubtiWiki
! This helps to get a rapid overview on all molecules that are Part of a pathway or that group together for other reasons, Check it out! Thank you,
@c-elfmann.bsky.social
@unigoettingen.bsky.social
@imprsgs.bsky.social
about 1 year ago
2
10
4
c-di-AMP formation in eukaryotic cells triggers formation of the inflammosome! Cool comment by Fabian Commichau (
@molmicrounihoh.bsky.social
) & Johannes Gibhardt!
#subtiwiki
www.nature.com/articles/s41...
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c-di-AMP is an envoy of inflammation - Nature Chemical Biology
Inflammasomes are multiprotein complexes that act as central signaling hubs by transmitting receptor-generated cues to downstream targets in the vertebrate innate immune system. New work finds that c-...
https://www.nature.com/articles/s41589-025-01931-2
about 1 year ago
1
4
1
News on persister cell formation in Bacillus subtilis!
@natmicrobiol.nature.com
#SubtiWiki
www.nature.com/articles/s41...
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A shared alarmone–GTP switch controls persister formation in bacteria - Nature Microbiology
Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.
https://www.nature.com/articles/s41564-025-02015-6
about 1 year ago
0
2
1
Antisense regulation of dnaA expression in Bacillus subtilis: Checkout this article I found in PLOS Genetics:
dx.plos.org/10.1371/jour...
#SubtiWiki
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An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis
Author summary DnaA is the highly conserved replication initiator and transcription factor found in virtually all bacteria. The synthesis and activity of DnaA are highly regulated, and different types...
https://dx.plos.org/10.1371/journal.pgen.1011625
about 1 year ago
0
0
2
News on the control of potassium transport! Congratulations,
@ihaenelt.bsky.social
, JanetVonck and teams!
www.nature.com/articles/s41...
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A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB - Nature Communications
KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus contains an intrinsically disor...
https://www.nature.com/articles/s41467-025-59546-z
about 1 year ago
1
4
0
Happy to share Christoph Elfmann's new paper that is now out in Trends in Microbiology! Discover tools to make the most out of AlphaFold and its iterations!
@c-elfmann.bsky.social
@cp-trendsmicrobiol.bsky.social
@unigoettingen.bsky.social
@imprsgs.bsky.social
#subtiwiki
www.cell.com/trends/micro...
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Cutting-edge tools for structural biology: bringing AlphaFold to the people
The recent application of artificial intelligence-based prediction of protein and protein complex structures by AlphaFold has revolutionized biology. Here, we give an overview of the tools that make this revolution accessible to experimental microbiologists without training in bioinformatics or sophisticated computer equipment, and show how this helps to gain new insights.
https://www.cell.com/trends/microbiology/fulltext/S0966-842X%2825%2900110-6
about 1 year ago
1
17
6
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