The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...

⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference! Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org #WSCC26 #SodiumChannels #PainResearch

🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease. 🧠 Abstracts due Nov 2 🔗 sodiumchannelconference2026.org/WELCOME/ #NaV #ionchannels #cardiacphysiology #scienceconference

🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome. 🧠 Abstracts due Nov 2 – all published in a JGP special issue! 🔗 sodiumchannelconference2026.org/WELCOME/

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community. Hugues Abriel and Angelika Lampert (@lampertlab.bsky.social) introduce the Special Issue (rupress.org/jgp/search-r...) illustrating the richness and continuing momentum of this field. rupress.org/jgp/article/...

This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

@jgp.org Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. From Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Sodium channels and clinical pain: join the finale of worldwide sodium channel seminar series by Janneke Hoeijmakers on June 24! Still not enough of Nav research? Safe the date for the 2nd ww Nav channel conference Feb 4 to 6, 26 in Grindelwald CH⛰️. www.sodiumchannelseminars.org

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is now out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading our article!

Slow inactivation of the fast sodium channel will be the topic of our next worldwide sodium channel seminar by Shimon Marom Tuesday May 27th on "Adaptive, slow sodium channel inactivation: impacts on neuronal excitability". www.sodiumchannelseminars.org for link and infos. 🧠 🎓

happening today, Tuesday 29th of April!

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan! www.jmcc-online.com/article/S002... 🧵 1/11

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7” www.sodiumchannelseminars.org for link and infos. See you there! #ionchannel #WSCS

Join us in Berlin in September! It is going to be a great meeting for those of you interested in neuropathic pain, itch and related conditions! #Painresearch #PainScience 🧪🧠

Miriam Meisler will give our next #WWSC seminar on Feb 25th. Come and discuss Nav1.6 pathophysiology in epilepsy and treatment options: "Down-regulation of SCN8A by ASO or CRISPR-i prevents seizures in a GOF model". Visit www.sodiumchannelseminar.org for info and link. See you there!

Commentary: Christian Jorgensen @jorlab123.bsky.social discusses new study from Elhanafy et al. (https://buff.ly/4haX9PQ) which shows how identical mutations in the voltage sensing domain of sodium channels can yield differential functional effects. https://buff.ly/4jpCRUD #IonChannels

Nociceptor sodium #ionchannels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology @JGenPhysiol https://buff.ly/4hku7gH #openaccess

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.

and a 3rd BOOM! for today: www.biorxiv.org/content/10.1... Again on VGNaCs. Navs enter the PROTAC era!! Well done Alex Chamessian and @robgereau.bsky.social

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH #Biophysics #Neuroscience #IonChannels

Thank you Ted! As always quick in catching new papers - this one is actually one i am really excited about. Thread to follow.

check it out! our lab's first review paper is officially in print and was selected as an editor's choice at Pain! fun summary video in this link in case you don't feel like reading🦠💩🐁: journals.lww.com/pain/fulltex...

Position at University of New Mexico in Anesthesiology: unm.csod.com/ux/ats/caree... I know that their surgery team has setup human DRG recovery and they are keen on an electrophysiologist who can help them to grow their work in human nociceptor neurobiology.

How could simulations elucidate Nav1.5 #ionchannel blockers mechanism? | Journal of General Physiology | Rockefeller University Press https://buff.ly/4gTs9Em

Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues. www.cell.com/cell/fulltex...

Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70

Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.

Interesting systemic approach to record spinal cord activity and laser evoked potentials

Before you disappear into the holiday break 🎄 , mark your calendars for a the next #WWSC talk: "More excited by other proteins than voltage: the unconventional function of the sodium leak channel complex" by @plesslab.bsky.social January 21st 2025. www.sodiumchannelseminars.org for info and link.

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins https://www.biorxiv.org/content/10.1101/2024.09.03.610923v1

Today Ben Corry, PhD @corrylab.bsky.social will be giving a talk "Understanding sodium channel inactivation and inhibition using molecular simulations" as a part of the #WorldwideSodiumChannelSeminars to connect: sodiumchannelseminars.org/Program-2024...

Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2 https://www.biorxiv.org/content/10.1101/2024.10.15.618559v1

Sodium channel endocytosis drives axon initial segment plasticity - congrats @ameliefreal.bsky.social et al! www.science.org/doi/10.1126/...

🚨 ‼️ December 17th at 4pm CET, 10am EST Ben Corry presents “Understanding sodium channel inactivation and inhibition using molecular simulations" as part of the worldwide sodium channel seminar series! Please visit www.sodiumchannelseminars.org  #IonChannels #Physiology #Science

Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS! #ionchannels #Nav

Neurite morphology effects on AP propagation in unmyelinated fibers.

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on www.sodiumchannelseminars.org. Mark your calendar and join in! #ionchannels #WSCS

PhD opportunity with Carole Torsney in Edinburgh, "Developmental tactile and pain processing in Grin2b related neurodevelopmental disorder": sidb.org.uk/phds/torsney... #PainResearch

Look what I made! 🦋 With help from Scholar Goggler scholargoggler.com Thank you @rikkesmoller.bsky.social for putting my attention on this.

A big THANK YOU to Drs Antonios Pantazis and Will Brackenbury. It was a real pleasure to read such a nice summary of our Worldwide sodium channel conference in Grindelwald earlier this year. The 2026 conference is in planning! www.sodiumchannelseminars.org. Thanks @iamshanovao.bsky.social for post

Very much looking forward! www.sodiumchannelseminars.org

My first post on blue sky! Carol Ann Remme will give her lecture in the worldwide sodium channel seminar series on Tuesday November 19th on: "Pharmacological and genetic approach to enhance cardiac sodium channel function" Join us! Visit www.sodiumchannelseminars.org for more infos and the link.