🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels 👉 journals.physiology.org/doi/full/10....

🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy 👉 journals.physiology.org/doi/full/10....

🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1... #IonChannels #Physiology

🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1... #Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky

🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬 🔧👉 rupress.org/jcb/article/... #Physiology #Cell #Science #Muscle

Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭 CITE-seq (119 Ab) Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓 bioRxiv 2025 www.biorxiv.org/content/10.1...

📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias. 📝 Submit by 2 June ⬇️

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins. Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis doi.org/10.1016/j.ja...

We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors. You can read the full study here:

For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵

Please read this.

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

#FreeToRead 👀 CONGRATULATIONS! An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency Mei Methawasin, et al. ➡️doi.org/10.1152/ajph...#FreeToRead

David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025) 📜 physoc.onlinelibrary.wiley.com/doi/full/10....

Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver www.sciencedirect.com/science/arti...

🔓Editorial From Timothy Musch et al. “APS Initiatives and Milestones: a Year in Review and a Look Ahead” ➡️doi.org/10.1152/phys...

🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1... #Physiology #Science #Circadian #Asthma

Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.” www.nytimes.com/2025/03/29/o...

Common hallmarks and potential mechanisms linking cancer, circadian rhythms, and aging.

•Night shift work is associated with increased inflammation •HDL-C levels are decreased among night shift workers •Night shift workers have prolonged heart rate-corrected QT intervals •HDL-C & QTc are promising indicators of CVD risk among night shift workers www.sciencedirect.com/science/arti...

For a presentation I am giving, I made a wordcloud of the titles of the NIH grants that were canceled. It is clear about the unscientific goals of this administration

🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1... #Physiology #Science #Circadian #Metabolism

NHK, Japan: 'Cracking the Complexity of Long COVID: Akiko Iwasaki / Professor of Immunobiology, Yale University' 'She talks about breakthroughs in understanding Long COVID, and the importance of diverse voices in science' www3.nhk.or.jp/nhkworld/en/...

“DOGE and HHS will determine whether a particular NOFO can be published, even if it has already been approved by an NIH advisory council of independent scientists who normally review such programs…’How is that decreasing regulation/bureaucracy?’” www.science.org/content/arti...

This recent #JournalClub by Federico Picciau @universitypost.bsky.social et al. examines the impact of exercise intensity on #neurogenesis and the work of Lambertus et al. (2024) 🧠 🏃 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 Did you hear the news? @apspublications.bsky.social reached our #SubscribeToOpen goals for 2025! Authors, find out how you can publish open access with APS #S2O journals.physiology.org/s2o-content-...

Really enjoyable Clock Club today at the University of Warwick. Fascinating and entertaining keynote by John Hogenesch @jbhclock.bsky.social and on top of that, Steph Williams @williams-steph.bsky.social from the lab won first prize for her talk! @bioclocksuk.bsky.social #chronobiology

Suprachiasmatic nucleus dysfunction may contribute to pathogenesis of anxiety and #depression via upregulation of the #BDNF -TrkB pathway in the striatum, potentially mediated by neural projections from the #SCN. Bmal1 gene within SCN may represent a novel therapeutic target for #mood disorders.

In our interview with Jennifer Lippincott-Schwartz, we discuss her research career, her advice on building collaborations and learn why she is looking forward to #biologists100. Jennifer will be speaking in our emerging technologies session. journals.biologists.com/jcs/article/...

www.sciencedirect.com/science/arti... new review by Bala Koritala and colleagues on the circadian biology of sleep apnea and cardiovascular consequences is out on JMCC in our special issue on circadian biology, check it out!

The importance of considering time of day for metabolic experiments www.nature.com/articles/s42...

“...problems arise when an early bird must stay up until 11 p.m. working late or a night owl has to wake up at 6 a.m. to take the kids to school,” Pendergast said. www.newswise.com/articles/jul...

Next Tuesday, Dr. Goragot Wisedchaisri will share his insights into the relationship between the structure of #volatgegatedsodiumchannel Nav1.7 and its role in #pain ⚛️ Please pay attention to the time schedule depending on your area: 🌍10 am (EDT)/ exceptionally at 3pm (CET) lnkd.in/eqvVXEsW

Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...

🚨🆕🫁 🔬 Fan et al reveal how ECM remodeling shapes ARDS progression- Collagen III, IV & lumican 📉 drop as damage worsens, while fibronectin & total collagen surge 📈 in late stage👉 journals.physiology.org/doi/abs/10.1... #ARDS #Pulmonary #Physiology #Science 🧪

🚨🆕🔬 Zhao et al model statin-induced myopathy using hiPSC-derived muscle cells-🧬 Statins disrupt proteostasis, triggering muscle atrophy via the FOXO1-Atrogin-1 axis 👉 journals.physiology.org/doi/abs/10.1... #Physiology #Science #Muscle

A must-read for anyone working on aortic disease models. - Standardizing Experimental Thoracic Aortopathy Research. www.ahajournals.org/doi/10.1161/...

👀 for somewhere to submit your research, review, short report? Check out the #AJPCell Call for Papers. 🖱️ow.ly/Pjm250VgNpJ

Delighted that my first bluesky post is to share our latest paper in @currentbiology.bsky.social comparing the visual code and retinal neurons of day and night active rodents. A fun journey of discovery with a wonderful team! @dns-uom.bsky.social www.cell.com/current-biol...

Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science openrxiv.org/introducing-... @openrxiv.bsky.social

🚨🆕 NIH-funded🔬by Garvin et al show ACE inhibitor in male & female SHR 🐀 shields from Ang II-induced fibrosis, but only males limit collagen🧬expression- understanding sex-specific efficacy of antihypertensive med👉 journals.physiology.org/doi/abs/10.1... #CardioSky #Physiology #Hypertension #Science 🧪

🚨🆕📚Review by Read et al discusses phosphodiesterases as potential targets for atrial fibrillation🫀 PDE2-5 & PDE8 regulate Ca²⁺ handling & electrical activity- PDE-based drugs for AF? 👉 journals.physiology.org/doi/abs/10.1... #CardioSky #Arrhythmia #Physiology #AtrialFibrillation #Science 🧪

Very exciting research- see a recent report! journals.physiology.org/doi/abs/10.1... #ARCV #Arrhythmia #Science

This has got nothing to do with curbing antisemitism. It has everything to do with using antisemitism as a figleaf to destroy independent thinkers because they are the antidote to Fascism

Exciting new work from Barna Lab @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

My op-ed about the importance of NIH funding was published in my hometown newspaper last week! @sciencehomecoming.bsky.social Check it out 👇🏻 www.knoxnews.com/story/opinio...

🚨🆕🔬 Wang et al show FBP1 deficiency rewires liver metabolism- Without this enzyme, ChREBP ramps up lipid synthesis, fueling fatty liver but also shields against energy crisis. 👉 journals.physiology.org/doi/abs/10.1... #Metabolism #FattyLiver #Science #Physiology

🚨New🫀🔬by Noort et al study the ‘Newfoundland Curse’- a deadly form of arrhythmogenic cardiomyopathy💔⚡ TMEM43-S358L iPSC-cardiomyocytes from patients arrhythmias but GSK3 inhibition restores stability 👉 journals.physiology.org/doi/abs/10.1... #CardioSky #Science #Physiology #Arrhythmia