Data indicate that CR even without a change in dietary composition could attenuate HFD-induced anxiety symptoms by modulating the gut microbiota, suppressing neuroinflammation, and regulating the brain insulin signaling pathway in adult male obese mice. www.sciencedirect.com/science/arti...

The dietary intervention influenced positively the metabolic, psychological, and circadian rhythm marker profile, highlighting potential interconnections between metabolism, circadian gene expression, and mental well-being. www.frontiersin.org/journals/nut...

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Human tissues emit ultra-weak biophotons across a 200-900 nm spectrum at approximately 10⁻¹⁶ W/m² intensity. Emissions originate from radiative decay of electronically excited species generated primarily via oxidative metabolic processes, ROS reactions during mitochondrial respiration

Being born with two X chromosomes brings a host of health benefits, and recognising this could lead to personalised medical treatments for men and women.

#Depression severity in adolescents correlates with #circadian desynchronization. These findings reveal the potential value of PER and SCN-OFC connectivity as biomarkers for MDD in adolescents. www.sciencedirect.com/science/arti...

Light-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome www.sciencedirect.com/science/arti...

Knowledgebase of Circadian-Related Risk Factors for Cancer Pathogenesis and Personalized Medicine bioinf.org.cn:9876

This meta-analysis revealed significant negative association between suboptimal #sleep & poorer #mentalhealth (r=−0.20, 95% CI [−0.23, −0.16]), with subjective sleep quality (β=0.11–0.19) and sleep schedule regularity (β=0.08) emerging as stronger predictors than objective sleep duration (β=0.05).

• We did a systematic review of seasons/gravity/geomagnetism affecting brain function • We found evidence across both animal and human literature supporting the premise • Evidence is, however, primarily behavioral, with inadequate mechanistic insights www.sciencedirect.com/science/arti...

Incorporating the #circadian context has not only clarified the IL-10 role in IAV infection but also underscored the pivotal #influence of circadian regulation on #immune responses. www.sciencedirect.com/science/arti...

This review aimed to elucidate the physiological mechanisms underlying exercise-induced #sleep improvements and assess its potential as a sustainable, low-risk alternative to pharmacotherapy in insomnia management. www.sciencedirect.com/science/arti...

From symptoms to systems: A comprehensive review of the clinical utility of classic and novel approaches to major #depression subtyping www.sciencedirect.com/science/arti...

The role of circadian rhythms is emerging as a contributor to healthy aging, with studies ranging from behavioral to molecular rhythms. In this review, we provide a summary of what is known about behavioral and systemic physiology rhythms with aging in humans. www.sciencedirect.com/science/arti...

Ginsenoside Re binds Drp1 Leu94 across species to restore mitochondrial homeostasis via Atg1/ULK1-dependent fission-mitophagy coupling in age-related degeneration www.sciencedirect.com/science/arti...

Both persistently long and short #sleep duration trajectories are associated with an elevated risk of #sarcopenia, compared to persistently high-normal sleep duration trajectories among middle-aged and older Chinese adults. www.sciencedirect.com/science/arti...

Physical Activity during #COVID-19 Pandemic: A 5-Year Retrospect

Long-term CoQ10 supplementation ameliorates weight gain, white adipocyte hypertrophy and inflammation in WAT, and metabolic disorders caused by combined estrogen deficiency and HFD, likely through its WAT browning effect. www.sciencedirect.com/science/arti...

This review aims to comprehensively summarize the underlying molecular mechanisms by which the cGAS-STING pathway regulates cellular senescence and aging. www.sciencedirect.com/science/arti...

The evidence suggests that TRE may modestly reduce TG levels, particularly in overweight individuals, with a limited impact on LDL-C, HDL-C, and TC. ADF demonstrated inconsistent effects on lipid profile. RIF presented modest improvements of TG and HDL-C. www.sciencedirect.com/science/arti...

Our findings indicate that a daily eating frequency of fewer than 3 times per day and a NFD of more than 12 hours are associated with an increased prevalence of diabetic kidney disease. Modifying circadian eating patterns may hold potential for improving renal outcomes in individuals with diabetes.

Higher screen time demonstrated significant associations with multiple adverse health outcomes- Lower physical activity levels, elevated BMI, reduced MQI, and poorer sleep quality.

Our study shows a direct link between the circadian rhythm and the response to Repair of DNA double-strand breaks in transcribed genes, opening strategies for chrono-chemotherapies based on topoisomerase poisons that induce DSBs in active loci. www.sciencedirect.com/science/arti...

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New—Thyroid cancer in adolescents and young adults: a population-based study in 185 countries worldwide thelancet.com/journals/lan... #thyroid #cancer #MedSky #EndoSky #OncSky

📝 Online now - the Spotlight "Unlocking the protein code: how our organs age across a lifetime" from Dongxue Wang and Jing Yang. #Proteostasis #Aging #BiologicalClocks #Proteomics Read it here: authors.elsevier.com/a/1m7Ts3S6Gf...

Central regulation of the heart in type 2 diabetes mellitus www.sciencedirect.com/science/arti...

Light as chronotherapy for depressed mood Journal Club by Angus C. Burns go.nature.com/47Mxg71

This review provides an overview of the advances in the last five years in the #anticancer activity of #melatonin in combination with synthetic drugs and natural products. www.sciencedirect.com/science/arti...

The intestinal clock shapes the diurnal sleep-wake cycle through temporally gating glutamine homeostasis and serves as a potential target for boosting the sleep rhythm and for managing sleep disorders. www.sciencedirect.com/science/arti...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis www.cell.com/molecular-ce...

The findings challenge the reliability of meta-analyses for complex indicators like body mass. Pain management should prioritize personalized strategies targeting biobehavioral mechanisms regulating both body hydration and fat mass. www.sciencedirect.com/science/arti...

Body Mass Index, Gray Matter Volume and peripheral inflammation in patients with post-COVID condition BMI contributes to GMV alterations in PCC patients, with both BMI and GMV demonstrating correlations with peripheral immunological markers. www.sciencedirect.com/science/arti...

#Butyrate: A potential mediator of obesity and #microbiome via different mechanisms of actions www.sciencedirect.com/science/arti...

Treatment strategies should incorporate consistent lifestyle & environmental modifications. Regular exposure to daylight, caffeine & alcohol restrictions, #sleephygiene optimisation, & implementation of calming pre-sleep routines can enhance #sleep quality and duration.

This review integrates current evidence on three dietary polyphenols, quercetin, allicin, and ferulic acid, that strengthen intestinal barrier integrity, remodel gut microbiota, and modulate neuroinflammatory cascades through antioxidant, anti-inflammatory, and gene-regulatory pathways.

Redox state is similar in subjects following omnivorous, vegan, vegetarian and low-carbohydrate high-fat diet www.sciencedirect.com/science/arti...

Multi-omics profiling reveals that time-restricted feeding improves metabolic health in HFHFD-fed mice independent of weight loss by enhancing iWAT thermogenesis through mitochondrial OXPHOS, with specific upregulation of ETC complex I proteins. www.sciencedirect.com/science/arti...

Based on the current literature, the evening #chronotype appears to be positively associated with adverse changes in glucose #metabolism, such as increased fasting glucose and insulin resistance, as well as type 2 #diabetes.

•BPA exposure during pregnancy causes enterotoxicity in mice; •Pineal melatonin ameliorates BPA exposure-induced enterotoxicity; •Pineal melatonin exerts ameliorative effects by modulating the tryptophan/AhR/mitochondria pathway. www.sciencedirect.com/science/arti...

•Outdoor ALAN exposure was related to shorter TL in children and adolescents. •The effect of ALAN on TL was more evident in boys than girls. •No significant association was observed between ALAN and mtDNAcn. •Environmental light exposure may play a role in cellular aging.

•Morning types demonstrated higher diet quality, greater eating awareness. •Morning types had lower eating and social jetlag. •Greater eating jetlag was linked to longer eating windows and higher social jetlag. •Mindful eating was inversely, and hedonic hunger positively, linked to obesity.

TAN ameliorates UC by upregulating BMAL1-dependent inflammation suppression and barrier integrity enhancement. This study underscores circadian clock modulation as promising strategy for UC management and provides mechanistic foundation for optimizing timed dosing regimens in clinical translation

We review findings describing the circadian regulation of the host response to infection, the circadian metabolic adaptations occurring during host–microbiota–pathogen interactions and how such regulation can influence the immune response of the host and, ultimately, its own survival.

• rTMS has a behavioral antidepressant effect in CUMS rat model of depression. • 10 Hz rTMS reduces dopamine D2 receptors in the striatum of depressive-like rats. • No changes in TH in the prefrontal cortex and dorsal striatum after rTMS. www.sciencedirect.com/science/arti...

Exposure to heavy metal mixtures significantly elevates diabetes-related MLTC risk through complex intermetallic interactions. www.sciencedirect.com/science/arti...