Nature research paper: Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 go.nature.com/4gPjgfA

A new very interesting study about the rhythm of O-GlcNAcylation by the Joanna Chiu's team #Circadian dx.plos.org/10.1371/jour...

• Right supTub volume underlies the comorbidity between schizophrenia and MS. • Right supTub is a possible target for improving cognitive deficits in schizophrenia. • MS may confound investigations of hypothalamic volume in schizophrenia. www.sciencedirect.com/science/arti...

CoQ10 supplementation could mitigate oxidative damage and preserve mitochondrial integrity, but we are far from being able to claim that it can represents an effective therapeutic strategy to complement current pharmacological treatments in RTT patients. www.sciencedirect.com/science/arti...

Hydrogen sulfide regulation in redox homeostasis and programmed cell death: mechanistic insights and implications in cancer www.sciencedirect.com/science/arti...

Air #Pollution as a Key Risk Factor for #Alzheimer’s Disease: A Comprehensive Review www.sciencedirect.com/science/arti...

Sex-specific associations between insomnia symptoms and mental health among Chinese young adults and the modified effect of CRY2 gene DNA methylation link.springer.com/article/10.1...

#Parkinson’s disease and the #gut-brain connection: unveiling pathways, mechanisms and promising therapies www.sciencedirect.com/science/arti...

The healing power of natural gifts: How the natural herbaceous plants targeting mitophagy can reverse diabetic complications www.sciencedirect.com/science/arti...

Role of capsaicin, circadian clock genes, and TRPV1 in colorectal carcinogenesis: Lessons and future directions www.sciencedirect.com/science/arti...

#Parkinson’s disease and the #gut-brain connection: unveiling pathways, mechanisms and promising therapies www.sciencedirect.com/science/arti...

Circadian misalignment is a critical, yet often overlooked, contributor to cancer incidence and associated economic burdens. Public health strategies—such as regulating shift schedules, reducing LAN exposure, and promoting chronotherapy—are essential to mitigate these risks.

Mechanisms of disruption of the gut–brain axis by environmental endocrine disruptors www.sciencedirect.com/science/arti...

Objective measures of blunted and fragmented 24 hour rest-activity rhythms were associated with adverse immune-metabolic outcomes. Stabilisation & amplitude-boosting of rest-activity rhythms may be particularly valuable targets for indicated prevention and early intervention of major mood disorders

Findings identify AA–EGCG as a multi-targeted nutritional strategy that mitigates glucocorticoid-induced muscle wasting by coordinating anabolic, catabolic, and mitochondrial pathways. www.sciencedirect.com/science/arti...

This study provides genetic evidence that SGLT-2 inhibitors may reduce BD risk, partly modulated by Clostridium sporosphaeroides. Identified pathways (e.g., calcium signaling) and dysregulated genes highlight mecolic-immune interplay in bipolar disorder.

#Curcumin and Curcumin-loaded poly(caprolactone) nanoparticles restore #mitochondrial function in an in vitro #Parkinson’s disease model. www.sciencedirect.com/science/arti...

Chronic stress-hypothalamus axis in #cancer processes.

Chronic #stress in #cancer development and progression 👇 www.sciencedirect.com/science/arti... @erictopol.bsky.social

This work underscores mitophagy as a double-edged sword in lung inflammation and proposes precision interventions to balance mitochondrial quality control, offering novel avenues for inflammatory lung diseases.

Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation www.frontiersin.org/journals/nut...

Effects of DNA #methylation inhibitors on light-induced #circadian clock plasticity www.sciencedirect.com/science/arti...

Data suggest that males and females differentially manifest the impact of social #stress on synaptic #mitochondria respiration.

How are #circadian rhythms established during development? This study shows that maternal metabolic signals oscillate in the fetal #SCN before the endogenous #clock becomes functional, offering a plausible mechanism for maternal entrainment of the developing clock @plosbiology.org 🧪 plos.io/3VD45fZ

Check out our latest in @cp-trendscancer.bsky.social where rockstar PhD student @laurarosenberg.bsky.social reviews cancer therapies known to induce innate immune responses through the reactivation of Transposable Elements.

• Permanent Standard Time is optimal. Its adoption would lead to the greatest reduction in obesity and stroke rates. • While permanent Daylight Saving Time is better than the current biannual shifts, it would yield smaller health benefits than Standard Time. www.pnas.org/doi/10.1073/...

A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women www.sciencedirect.com/science/arti...

• Intrinsic field enables self-organization via feedback. • Max complexity requires a causal, compressed field. • External fields can reprogram patterns. • Coding strategy depends on cellular sensitivity.

New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...

Time-Restricted Eating, ANGPTL4, and Reduction in Residual Cardiovascular Risk www.mdpi.com/3529416

How the #brain adapts to nature's rhythms: a year of neuroimaging in a #seasonal mammal www.sciencedirect.com/science/arti...

Strength was more consistently influenced by ToD, whereas MC was primarily associated with motivation. These findings highlight the importance of considering circadian rhythm in training and testing for females.

The Relationship Between Perceived Stress and Night Eating moderated by Personality: Cognitive Emotion Regulation as a Mediator www.sciencedirect.com/science/arti...

• There was a 12.11% prevalence of depression and a high prevalece of skipping breakfast (72.27%). • Skipping breakfast was significantly associated with breakfast quality • Depression levels were associated with being female, poor sleep quality, family history of psychological disorders

Sleep-disordered breathing subtypes and future diet quality in the Multi-Ethnic Study of Atherosclerosis www.sciencedirect.com/science/arti...

Weekly administration of 50,000 IU of vitamin D for six months proved effective in reducing depressive symptoms and suicide risk while improving cardiovascular health markers, highlighting its promise as an accessible, low-cost adjunctive therapy in psychiatric and primary care settings.

Sunlight Deficiency Increases Suicide Risk A 1 standard deviation drop in sunlight exposure increased suicide rates by 6.76%.While seasonal depression peaks in winter, suicides peak in spring/summer. Biological Mechanism: • Serotonin production • Vitamin D synthesis • Circadian rhythm

The central clock drives metabolic rhythms in muscle stem cells www.sciencedirect.com/science/arti...

Molecular Mechanisms Underlying Obesity-Induced Memory Dysfunction: A Comprehensive Narrative Review www.sciencedirect.com/science/arti...

Exploring the connection between the #Mitochondrial DNA and the #Circadian Rhythm: Insights into Mitochondrial Biogenesis and its Dynamics link.springer.com/article/10.1...

Children and teens who had a Covid reinfection had a doubling of #LongCovid risk (PASC) and a significant increase in many other adverse outcomes (Figure) www.thelancet.com/journals/lan...

The process of mitomeiosis

Light exposure in zebrafish cells activates a genetic program that turns on genes responsible for: • Mitochondrial function • Heme metabolism This is a direct, light-triggered response that helps the cell adapt to and manage the increased oxidative stress caused by light.

Targeting mental #health through pharmacologically active #natural compounds: State of the art and future perspectives www.sciencedirect.com/science/arti...

Frontiers | Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation www.frontiersin.org/journals/tox...

In situ construction "Metabolism-Immunity" crosstalk rewiring bioreactor with single-dose mitochondria energizing hydrogel for amplifying T cell fitness and anti-tumor immunity www.sciencedirect.com/science/arti...

Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication www.cell.com/cell-host-mi...