NETs contribute to Th17 bias and MHC-II over-expression in HT, suggesting a role in shaping the adaptive immune response. Vitamin D restrains NETosis and restores T-cell homeostasis, highlighting its potential as an adjunctive therapy for HT.

Meal timing represents a modifiable factor influencing metabolic health and possibly early carcinogenesis. Aligning eating behavior with intrinsic #circadian rhythms may help mitigate #cancer risk and improve long-term well-being. www.sciencedirect.com/science/arti...

• #Circadian disruption causes #immunity risks • Clock genes are potential targets for treating #autoimmune diseases. www.sciencedirect.com/science/arti...

Our study revealed that depression severity in adolescents correlates with circadian desynchronization. These findings reveal the potential value of PER and SCN-OFC connectivity as biomarkers for MDD in adolescents. www.sciencedirect.com/science/arti...

Chronoregulatory and neuroprotective effects of yeast β-glucan against systemic inflammation www.sciencedirect.com/science/arti...

• Dim blue light at night aggravated kidney damage and fibrosis in HFD. • Exposure to dim blue light at night increased oxidative stress and inflammation in kidney of mice fed a HFD. • dBL altered renal circadian clock genes changes by elevating plasma corticosterone levels and acting on receptors.

Imagine if a nasal spray could make you immune not only to the viruses that cause COVID-19 and influenza, but to all respiratory diseases go.nature.com/4rx3aMe

Melatonin inserts into neuronal membranes, targets cholesterol-rich rafts, and connects different lipid phases without disrupting their structure. www.sciencedirect.com/org/science/...

Chronic cold exposure and extreme temperature variability independently increase MASLD risk, with amplified effects in metabolically vulnerable populations. www.sciencedirect.com/science/arti...

Outdoor artificial #light at night is linked to a higher risk of type 2 #diabetes and disrupted glucose #metabolism. Obesity partly explains this link, accounting for 22–36% of the effect. Vulnerable groups include the elderly, men, smokers, and those with lower socioeconomic status.

Together, these findings show that adolescent binge-like eating induces glial reactivity and dopaminergic disturbances in key reward- and control-related brain regions, alongside changes in anxiety-like and risk-taking/impulsive-like behaviors. www.sciencedirect.com/science/arti...

Presentation and Temporal Nature of Postacute Sequelae of SARS-CoV-2 Infection in a US National Cohort www.sciencedirect.com/science/arti...

#VitaminD supplementation effectively raises blood levels in #IBD patients. It may offer benefits - such as reducing disease activity, #inflammation, and improving quality of life - particularly in those with baseline deficiency. However, evidence is inconsistent, effects vary among patients.

Mito-Mood Hypothesis. #Mitochondria act as a central hub integrating #circadian rhythms (blue), neuroinflammation (red), and synaptic plasticity/LTP (green).

Findings demonstrate that sex and photoperiod shape hepatic redox homeostasis in obesity, supporting a melatonin-NRF2-circadian regulatory axis that connects environmental timing cues with sexually dimorphic redox responses. www.sciencedirect.com/science/arti...

Amazing data here - just 100lux of room light while staying up late seems to delay teens enough that 8000lx of morning bright light delays them further:

Current perspectives on #circadian regulation of #mitochondrial dynamics in #mood disorders and perioperative #stress www.frontiersin.org/journals/pha...

The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective www.sciencedirect.com/science/arti...

This article reviews molecular mechanisms underlying circadian rhythm disruption during aging, with a focus on telomere homeostasis, SIRT1-mediated epigenetic regulation & NAD+ metabolic pathway. www.frontiersin.org/journals/phy...

#Light pollution and risk of #diabetes: a systematic review and meta-analysis of observational studies • Light pollution was associated with a 31% increase in risk of diabetes. • Strongest association was observed for indoor light pollution , where risk increased by 66%.

This review synthesizes the features of gut #microbiota #circadian dynamics, the intrinsic and extrinsic factors regulating microbiota oscillations, and the precise microbial intervention measures targeting temporal patterns. www.frontiersin.org/journals/cel...

Structured #exercise may improve #sleep quality and cognitive function in shift workers, though substantial uncertainty remains. Moderate-intensity aerobic exercise shows promise, particularly when timed post-shift for sleep benefits or pre−/during-shift for alertness enhancement.

tPBM holds promise as an effective antidepressant strategy. Improvement in sucrose consumption, increase in Complex IV activity in prefrontal cortex, and the increase in NO concentration in hippocampus, associated with a reduction in damage to membrane lipids. link.springer.com/article/10.1...

People with bipolar disorder who live in places with very dark winters and very bright summers are more likely to have relatives also affected by mood disorders. This suggests that extreme differences in access to sunlight may 'trigger' the genetic predisposition to this illness within families.

This review synthesizes current evidence on hormonal, metabolic, and metabolite biomarkers in LC. While vitamin D deficiency is prevalent in LC, being associated with neurocognitive symptoms, delayed recovery and poor physical performance.

Painter Schmidt-Rottluff (1906) by Emile Nolde

These findings reveal that adipocyte circadian disruption impairs metabolic health through mitochondrial complex I dysfunction, establishing clock control of complex I as a key regulator of metabolic homeostasis.

We discuss how #plastics can impact cellular #metabolism, affect developmental #brain processes, and increase vulnerability to neurodevelopmental disorders and #depression. www.sciencedirect.com/science/arti...

Mitochondrial control of fuel switching via carnitine biosynthesis www.science.org/doi/10.1126/...

Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid www.sciencedirect.com/science/arti...

Social disconnection: From cortisol-oxytocin imbalance to endothelial dysfunction, a narrative review of mechanisms and potential interventions www.sciencedirect.com/science/arti...

Findings identify the vHPC NPY-INs as a critical hub linking #circadian regulation and energy balance, offering new insight into #neural mechanisms underlying mistimed feeding and #metabolic disorders. www.sciencedirect.com/science/arti...

Arm-December/May 1884/85 https://botfrens.com/collections/46/contents/3108917

Findings highlight sex-specific differences in the hippocampal dentate gyrus's response to chronic stress and shed light on the molecular mechanisms underlying sex-based differences in stress susceptibility. www.sciencedirect.com/science/arti...

•Evening #chronotype was linked to higher #burnout •Insomnia was associated with higher burnout •Insomnia mediated associations between internalizing symptoms and academic burnout.

• #Breakfast skipping linked to low skeletal #muscle mass (SMI) • ≤12 meals/week associated with low SMI in men and women • Low meal frequency linked to low SMI and handgrip strength in men • Stronger associations observed in men than in women www.sciencedirect.com/science/arti...

• Yeast beta-glucan reduced URTI symptom severity • Moderate-dose yeast beta-glucan improved mood and vitality • Yeast beta-glucan was safe with stable metabolic biomarkers www.sciencedirect.com/science/arti...

Our findings suggest that TRF improves cognitive function and reduces neuronal apoptosis in AD mice by modulating the GCK/NPY pathway. These results highlight TRF as a potential non-pharmacological intervention for Alzheimer’s disease, offering new insights into its underlying mechanisms.

Study suggests that exposure to artificial #light at night during early development may increase susceptibility to diseases in adulthood. Mental & behavioral disorders: risk lower by 21% ( #Anxiety risk lower: 29%, #depression risk lower: 27%) #Obesity & #diabetes – risk lower by 38%

Biophotons represent ultra-weak light emission (200–800 nm) spontaneously generated by living cells through oxidative metabolic processes, particularly within mitochondria.

L-DOPA shows potential as a therapy to slow or prevent retinal degenerative diseases, but robust clinical trial evidence is needed before it can be adopted in practice.

These findings, for the first time, demonstrate the ability of PDNVs to directly target mitochondrial functions and modulate inflammation, positioning LB-NVs as a highly promising strategy for treating chronic skin inflammation. www.sciencedirect.com/science/arti...

• #Estrogen dysregulation is central to the chronic inflammation and progression of #endometriosis. • Gut #microbiota influences estrogen #metabolism and may play a key role in endometriosis-associated inflammation.

Circadian clocks are universally self-sustained oscillators Annually changing daylength is sufficient to select for self-sustained oscillators Entrainment properties (i.e. “type 0” vs. “type 1” resetting) affect fitness Both daily and annual environmental cycles molded the properties of daily clocks

The role of #circadian disruption, #sleep dysregulation, lifestyle factors, and metabolic reprogramming in the pathogenesis and progression of #ovariancancer www.sciencedirect.com/science/arti...

Reductive stress and mitochondrial dysfunction: The hidden link in chronic disease www.sciencedirect.com/science/arti...

In this Forum article, we hypothesize that exercise, as a metabolic challenge, provides a powerful physiological model to investigate the clock–mitochondria axis and its regulatory role in muscle function and metabolic health in humans.

Growth hormone enhances mitochondria biogenesis and endows mitochondrial thermogenesis in murine adipocytes www.sciencedirect.com/science/arti...