This review summarizes the mechanisms by which the reproductive tract and gut #microbiota dysbiosis triggers #infertility, focusing on dysbiosis of bacterial ecological ratios, microbiota-mediated imbalance of the immune system, inflammatory responses, and effects on signaling pathways.

SD for 7-day or 14-day may impair emotional behaviors by disrupting the RNA expression of clock genes and the Sirt6/Hmgb1 inflammatory axis, while sleep recovery for 14-day or 21-day can partially reverse this impairment.

Over a median 3.67 years, incident #T2D was associated with higher risks of all-cause dementia (adjusted hazard ratio [AHR] 1.95, 95% CI 1.71–2.21), AD (2.21, 1.88–2.59), and VaD (1.57, 1.20–2.07). Glucose-lowering treatment was associated with lower #dementia risk versus no treatment.

Daily supplementation of 100-mg ubiquinol for 12 weeks improves insulin sensitivity for prediabetic patients with a favorable safety profile. The observed effect sizes support further investigation in larger, adequately powered trials to confirm the metabolic effects of ubiquinol.

The study provides mechanistic insights into BPS-induced metabolic dysfunction and highlights the need to reevaluate the safety of BPS as a BPA alternative, suggesting CYP2E1 as a potential therapeutic target for counteracting environmental obesogen effects. www.sciencedirect.com/science/arti...

#Light early in the day was positively correlated with good sleep and light at night was negatively correlated with good #sleep. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#Thyroid Hormone Signaling Causally Influences #Pancreatic Disease Risk: Evidence from Mendelian Randomization and Multi-Omics Integration www.sciencedirect.com/science/arti...

Complex Interactions Between Stress, Nutrition, Gut Microbiota, and Infectious Diseases and Their Impact on Health in Global Conflicts: A Narrative Review www.sciencedirect.com/science/arti...

Over half of the preterm human milk samples exhibited diurnal macronutrient rhythmicity, mainly in fat levels. The observed rhythms had varying peak times, suggesting phase differences of the maternal rhythms.

This review explores the critical relationship between #mitochondrial stress and neurodegeneration, highlighting the molecular mechanisms and biomarkers involved. It delves into the multifaceted role of #melatonin as a potent neuroprotective agent. www.sciencedirect.com/org/science/...

•Intracellular signaling affecting the neuronal activity may serve as ‘cellular sleepiness’ •Molecular mechanisms of sleep are now being integrated with circuit-level mechanisms •Principles of sleep regulation provide hints for controlling and engineering sleep www.sciencedirect.com/science/arti...

Stress protection by your group - increasing group size reduces physiological stress contagion www.sciencedirect.com/science/arti...

Both the SCN and habenula rely on glutamatergic, GABAergic, and monoaminergic signaling, and both express clock genes that influence their intrinsic oscillatory properties. Disruptions in these pathways are well documented in depression and suicide risk. www.sciencedirect.com/science/arti...

•Bacteria and viruses shape neurotransmitters, SCFAs, and gut metabolites •Dysbiosis drives Alzheimer's, Parkinson's, autism, and schizophrenia risk •Gut virome, especially phages, regulates bacteria and neurodevelopment •Microbiome-based therapies offer novel strategies for neurological disorders

The Role of Selenium in Modulating Sperm Count and Ferroptosis Pathways in Male Reproductive Health www.sciencedirect.com/science/arti...

Low-level LED red-light therapy significantly accelerates axial elongation in hyperopic children and reduces interocular differences in anisometropic cases, suggesting that it may promote more balanced binocular refractive development. www.sciencedirect.com/science/arti...

Among overweight and obese individuals, lower phasor magnitude—indicating poor synchronization between light and activity cycles—was associated with higher risks of advanced CKM stages and increased mortality. link.springer.com/article/10.1...

Our findings demonstrate: plasma redox states vary diurnally in children and are more oxidized in those with MASLD. Fructose intake increased oxidation of the GSH/GSSG redox couple and lowered GSH concentrations overnight, indicating heightened oxidative stress www.sciencedirect.com/science/arti...

First meta-analysis describing evidence landscape for #heat therapy in #depression • Demonstrates small but consistent effects across different heating modalities: Hedges' g = 0.32 (95% CI, 0.12-0.52) www.sciencedirect.com/science/arti...

In this week’s @science.org cover article, we discover tree bark is a hidden habitat for abundant, diverse, and specialized microbial life that actively regulate our climate 🦠. Bark isn't just an inert armor of tree but an active interface for climate and biodiversity www.science.org/eprint/7H9PX...

Among overweight and obese individuals, lower phasor magnitude—indicating poor synchronization between light and activity cycles—was associated with higher risks of advanced CKM stages and increased mortality. link.springer.com/article/10.1...

New in the February Issue: Circadian and sleep medicine: challenges and future directions for metabolic and endocrine research www.thelancet.com/journals/lan... #MedSky #EndoSky

•Night shift work associated with cardiovascular injury biomarkers & alters #gut #microbiota •Gut microbes associated with night shift-related endothelial dysfunction •First evidence in platform workers linking #circadian disruption to #cardiovascular risk via microbiome changes

Immunometabolism: Is cyanide a missing link between metabolic pathways and immune function? www.sciencedirect.com/science/arti...

#Chronotype & #depression: Global systematic review & meta-analysis • Evening chronotype is linked to 83% increased depression risk, highlighting circadian disruption as critical potentially modifiable variable • Morning chronotype demonstrates consistent protective effects, with 12% risk reduction

ipRGC properties prevent light from shifting the SCN clock

new out in Nature www.nature.com/articles/s41...

Impact of time-restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high-fat diet-induced obesity.

Chronic #stress and the #mitochondria –telomere axis: human evidence for a bioenergetic-debt model of early aging Preserving mitochondrial resilience through cycles of stress + recovery is crucial for maintaining telomere maintenance capacity, and thus, for healthy #aging.

Outdoor night light exposure and sleep structure Moderate outdoor nighttime #light levels are associated with slightly longer light sleep durations, whereas higher NTL levels may negatively impact deep #sleep.

Acute myocardial infarction incidence peaks on Mondays and in winter, while mortality is higher during weekends and colder months.

Chronobiological rhythms on glucose metabolism in gestational diabetes: A systematic review Short sleep duration, late eating, evening chronotype, and night-shift work increase the risk of GDM. Meal timing and high carbohydrate intake in the morning influence glucose variability

Polymorphisms in CLOCK and ARNTL/BMAL-1 genes in multiple sclerosis: a systematic review and meta-analysis Based on the limited available evidence, there may be an ethnic-specific association between ARNTL/BMAL-1 and CLOCK gene and MS susceptibility.

The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function journals.sagepub.com/doi/10.1177/...

•First crystal structure of a Type II cryptochrome from a migratory songbird •Type II cryptochromes from migratory songbirds function as circadian regulators •Type II cryptochromes do not bind FAD www.cell.com/iscience/ful...

Problematic social media or phone use was associated with increased smartphone time in school, especially on social apps, among US adolescents; disparities in use were observed by age, race, and household income. @jasonmnagata.bsky.social @ucsfchildrens.bsky.social ja.ma/4jv0N9y

This review explores for the first time the complex interplay between infections and neurological disorders, highlighting the potential of mushrooms not only as functional foods but also as complementary allies in safeguarding brain health. www.sciencedirect.com/science/arti...

•Daytime noise exposure is more strongly associated with breast cancer incidence •ER+ tumors were slightly elevated for both daytime and nighttime noise www.sciencedirect.com/science/arti...

•This systematic review strengthens the evidence linking ALAN exposure to sleep disturbance. •Individuals with higher ALAN exposure had a 27 % increased risk of sleep disturbance. •Despite remaining methodological limitations of included studies, certainty of evidence was high.

Time-restricted eating slightly reduces fat mass, body mass index, and body fat percentage in resistance-trained individuals, with no significant changes in fat free mass and body mass. The effects appear to result from energy deficit during fasting periods alternating with feeding.

This review will summarize the family of opsins in mammals and focus on the role of non-visual opsins in circadian photoreception. link.springer.com/article/10.1...

Mitochondria-targeted co-assembled nanosystem with multimodal mitochondrial DNA level control to alleviate inflammation and promote chronic wound healing www.sciencedirect.com/science/arti...

Light Therapy in Seasonal Affective Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled and Crossover Trials Light therapy can reduce symptoms of seasonal affective disorder, with a minimum of two weeks recommended to achieve desirable outcomes.

This review critically synthesizes current neurophysiological findings on comorbidity between #depression & #sleep disorders. Drawing upon multidisciplinary body of literature, the paper delineates overlapping neurochemical, hormonal, and inflammatory mechanisms www.sciencedirect.com/science/arti...

Reactive oxygen species in exercise biology: from adaptive stress response to cell signaling and beyond www.sciencedirect.com/science/arti...