14 June 1921 | A Pole, Stanisław Trałka, was born in Wąbrzeźno. He was deported to #Auschwitz on his 19th birthday in the first transport of Poles to the camp on 14 June 1940. No. 660 He perished in the camp on 2 October 1942.

Cryo-EM structures of human dopamine transporter (hDAT): apo, substrate-bound, & antidepressant-bound. Bupropion binds central pocket in both DAT & NET, explaining dual NRI/DRI action. Vanoxerine traps DAT in outward-open state (distinct pose). K+ occupies Na+ sites, suggesting regulatory role.

Lactate exerts neuroprotective effects through mechanism associated with enhanced 14-3-3 lactylation, reduced NLRP3/GSDMD pathway activation, attenuated GSDMD-associated mitochondrial injury, decreased cytosolic mtDNA levels & suppression of cGAS–STING signaling www.sciencedirect.com/science/arti...

Cumulative ultra-processed food intake from 6mo to 6y – NO association with cognitive performance at 2y or 6y. BUT: higher UPF → smaller subcortical volumes at 6y (accumbens, amygdala, pallidum, putamen, thalamus; FDR p<0.05). Each 10% higher UPF → 1.9% smaller volume.

81 meta-analyses, 254M participants •VitD deficiency in schizophrenia 65% •Depression in diabetes 62% •Anxiety in PCOS 48% •DEP in diabetic foot ulcer 47% •MCI in T2D 45% •DEP in PCOS:37% •DEP in metabolic syndrome 31% •Anxiety in T1D 21% •Obesity in autism 17% www.sciencedirect.com/science/arti...

Knowledgebase of Circadian-Related Risk Factors for Cancer Pathogenesis and Personalized Medicine bioinf.org.cn:9876

Here, we review mechanistic links between glucocorticoids signaling and systemic aging and discuss strategies to mitigate the age-accelerating consequences of persistent GC exposure. www.sciencedirect.com/science/arti...

This article summarizes the effects of PM2.5 on the thyroid gland and its potential toxic mechanisms, outlines future research directions, and provides a scientific basis for developing precise protection strategies and air quality standards. t.co/CBpyTsYXB3

Meta‑analysis (14 studies) Morning blue light therapy (30-60 min, 10,000 lux) improves: • sleep fragmentation ↓~50% • sleep onset latency ↓~25% • night awakenings ↓~30% • WASO ↓~25% • sleep efficiency ↑~15% • reduces daytime sleepiness www.sciencedirect.com/science/arti...

#Throwback 🧪 REVIEW | The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease E Asimakidou, S Pluchino, B Ambrogina Silva & L Peruzzotti-Jametti

Circadian nature of microbiota we summarise current knowledge on the microbial succession and evolutionary trajectory of the gut microbiome from neonates to adults aged 100 years and older, subsequently focusing on diurnal rhythms and seasonal patterns. www.sciencedirect.com/science/arti...

Most versatile natural products for insomnia (preclinical evidence): • Ziziphus spinosa (GABA+5-HT) • Ginsenoside Rg1 (↓orexin, ↓CRH) • Passiflora incarnata (GABA+melatonin) • Jujuboside A (mitochondria) • Ganoderma lucidum (anti-inflammatory) www.sciencedirect.com/science/arti...

Insulin in brain: The physiological functions and therapeutic insights for neurodegenerative diseases www.sciencedirect.com/science/arti...

Time-restricted feeding (TRF) quadruples cross-tissue coordination of mitochondrial gene rhythms in mice (22 tissues). Coq10b emerges as top marker. Nutrient timing synchronizes mitochondria across organs – not just what you eat, but when. www.sciencedirect.com/science/arti...

Time matters: circadian genetics and the molecular logic of human health and disease www.nature.com/articles/s41...

Vitamin D supplementation in COVID-19 (20 RCTs, n=2756): ↓ mortality by 20% (RR=0.80), ↓ ICU admission by 26% (RR=0.74). No effect on hospital stay or ventilation. Target serum 25(OH)D ≥30 ng/mL. www.sciencedirect.com/science/arti...

My Postdoctoral project 🫶🏽

This review systematically examines how key biophysical signals regulate bone remodeling and discusses emerging therapeutic strategies that translate these principles into clinical applications, including mechanical, electrical, magnetic, acoustic, optical, and thermal stimuli.

President Zelenskyy issued an official decree allowing Moscow's Victory Day Parade, under humanitarian purposes. The parade has been drastically decreasing in personnel and equipment for several years now.

Review provides comprehensive insights into the relationship between microbial Tryptophan metabolism and human aging, and it opens up novel opportunities for prevention, diagnosis, and therapy of disease. www.sciencedirect.com/science/arti...

Chrononutrition (TRE 10-12h, ADF, 5:2) delays aging via circadian clocks, AMPK/mTOR/sirtuins & gut microbiota. But ≤8h eating window linked to higher mortality (U-shaped). Skipping breakfast, late-night eating & irregular meals increase disease risk. www.sciencedirect.com/science/arti...

#Circadian clock control of #breastcancer hallmarks: molecular mechanisms and therapeutic implications link.springer.com/article/10.1...

High temperature increased psychiatric hospitalizations in youth (Australia, 719k cases): cold season RR=3.03 (+203%), warm season RR=1.92 (+92%). Highest risks: substance use, depression, anxiety, OCD, ADHD, conduct disorders (both seasons); schizophrenia, eating disorders, self-harm (cold only).

Rhythms of Mood: Bidirectional Regulation of Molecular Clocks and Neurotransmission in Affective Disorders Findings from animal models and clinical research demonstrating how core clock genes directly regulate neural networks controlling reward, stress responses and synaptic plasticity.

Environmental microplastics and liver health: Brief review on human exposure and accumulation, hepatotoxicity mechanism, and intervention strategies www.sciencedirect.com/science/arti...

24–Hour Rest-Activity Rhythms and Epigenetic Age Stronger rest-activity rhythms (actigraphy, n=207, mean 68y) linked to epigenetic age 8-16 months younger; fragmented rhythms & night activity linked to 7-9 months older. RAR may predict biological aging. jamanetwork.com/journals/jam...

Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment www.sciencedirect.com/science/arti...

The hallmarks of neuro-immune reprogramming in cancer This framework positions neuro–immune regulation as an under integrated systems-level determinant of immune heterogeneity, therapeutic responsiveness, and resistance in #cancer. www.frontiersin.org/journals/imm...

Tryptophan tetrad (280nm) & MTHF amplify light absorption & electron transfer in cryptochrome. Protein environment (3-5Å) boosts FAD absorption (no shift). Quantum RT-TDHF (1,200 atoms) reveals how neighboring amino acids enhance magnetoreception & circadian rhythms www.biorxiv.org/content/10.6...

Fascinating article! As suggested, it will be unteresting to study such phenomenon in vertebrates! Rhythmic protein condensation in the circadian regulation of glycogen metabolism: iScience www.cell.com/iscience/ful...

Higher daytime light (≥1916 lux) reduces: • GI cancer risk by 13% • GI cancer mortality by 24% • Pancreatic cancer incidence by 42% • Pancreatic cancer mortality by 53% Light was a stronger predictor than sleep, diet, depression, or alcohol.

Higher daytime light exposure reduced gastrointestinal cancer risk (89,069 participants). Strongest protection for pancreatic cancer. onlinelibrary.wiley.com/doi/10.1002/...

#Throwback 🧪 PERSPECTIVE | The cyclic metabolic switching theory of intermittent fasting Mark Mattson

Systematic review: collagen peptides (from fish/livestock by-products) delay skin aging via multi-target mechanisms: • antioxidant (Nrf2) • anti-inflammatory (NF-κB, MAPK) • ECM synthesis (TGF-β/Smad) Reduce wrinkles, increase hydration/elasticity www.sciencedirect.com/science/arti...

New framework: host-microbiome decoupling (not just dysbiosis). 8 hallmarks: signaling failure, immune miscalibration, barrier breakdown, pathological metabolites, endocrine uncoupling, neuro disruption, ecological destabilization, temporal desync. www.frontiersin.org/journals/mic...

Scoping review 19 studies: melatonin-rich foods (cherries, kiwi, tomatoes, milk) & sleep. Improves sleep in insomniacs, elderly, athletes (↑TST, ↑SE, ↓SOL, ↓WASO) but NOT in healthy young. Mechanism: synergy polyphenols, not just melatonin. onlinelibrary.wiley.com/doi/10.1002/...

Scoping review 21 studies (2000-2024) photostimulation in Alzheimer's: bright/blue light, 40 Hz rhythmic, PBM. Improves or slows cognitive decline (MMSE, MoCA, ADAS-Cog), stabilizes sleep-wake, reduces neuropsychiatric symptoms. www.dovepress.com/application-...

Metaanalysis 31 RCTs melatonin 1-10mg/day 14-365 days. No effect on fasting glucose. But improved HbA1c fasting insulin and HOMA-IR (insulin resistance). Melatonin may improve insulin sensitivity without lowering fasting glucose. Modulatory role in metabolism. www.sciencedirect.com/science/arti...

Systematic review 9 preclinical studies: magnetic fields 1-50Hz 20mT-1.5T activate autophagy via PI3K/AKT/mTOR inhibition ROS Ca2+ microRNA. Neuroprotection in AD vascular dementia stress. Autophagic death in cancer. But most studies lacked flux verification. www.sciencedirect.com/science/arti...

Meta‑analysis (reward sensitivity & circadian behaviors): eveningness vs morningness – no association in community samples, but moderate positive association in clinical samples (depression, addictions). Social jetlag (small negative), social rhythm disruption (moderate positive).

Network meta‑analysis (Alzheimer’s) Photobiomodulation (PBM, SMD 0.66, SUCRA 87.3%) Enriching environment (SMD 0.69, SUCRA 83.8%) more effective than drugs (SMD 0.36, SUCRA 54.7%). Cognitive stimulation & exercise also beneficial. Music therapy no different from control

Temporal regulation of #GlucoseMetabolism is governed by the endogenous #CircadianClock & less dependent on feeding rhythms doi.org/10.1371/jour... @WeljieLab #Physiology #MetabolicHealth #TranslationalScience

Serotonergic psychedelics for Autism spectrum disorder: Neurobiological mechanisms and translational prospects www.sciencedirect.com/science/arti...

Rhythms of Mood: Bidirectional Regulation of Molecular Clocks and Neurotransmission in Affective Disorders Findings from animal models and clinical research demonstrating how core clock genes directly regulate neural networks controlling reward, stress responses and synaptic plasticity.

Chronic #pain therapy: Green #light (↑endocannabinoids, analgesia) Blue light (biphasic, dose-dependent) Laser PBM (functional modulation, not structural repair ↓neuroinflammation) www.sciencedirect.com/science/arti...

#Parkinson's disease: When the gears of time stiffen — The life-and-death game of #circadian rhythms, sleep disorders, and neurodegeneration www.sciencedirect.com/science/arti...

SCN has ~20,000 heterogeneous neurons (AVP ~20%, VIP ~10%, GRP, NMS, CCK, PROK2). Conditional knockouts show: VIP is key for synchrony (Bmal1 KO → desynchrony), AVP modulates period, NMS needed for long-term coherence. GABA & neuropeptides mediate coupling. www.sciencedirect.com/science/arti...