Ken Campbell
@cardiaccampbell.bsky.social
π€ 215
π₯ 176
π 30
Director of Translational Research for Cardiovascular Medicine at the University of Kentucky
pinned post!
On behalf of our team at
@ukresearch.bsky.social
, highlighting "Patients who donate biospecimens for research leave a valuable and underappreciated scientific legacy". We can all remember that behind every data point is a person, a family, and a story.
www.ahajournals.org/eprint/8HECU...
loading . . .
American Heart Association Journals
https://www.ahajournals.org/eprint/8HECUBWKWGMGRJRXMDH4/full?redirectUri=%2Fdoi%2F10.1161%2FCIRCHEARTFAILURE.125.013242
4 months ago
0
1
1
reposted by
Ken Campbell
University of Kentucky Research
2 months ago
Researchers at UK have been awarded a prestigious Centers of Biomedical Research Excellence (COBRE) grant. This five-year, $11 million grant will strengthen the foundation of diabetes prevention research throughout the Commonwealth. Learn more:
https://bit.ly/3Xf9E52
0
2
2
Alpbach Motors Workshop, brilliant discussion-based motility meeting in a stunning alpine setting in Austria, March 21-27, 2026. Registration open until December 19. Best conference hotel ever.
www.boeglerhof.at/en
Register at:
docs.google.com/forms/d/e/1F...
2 months ago
0
3
1
reposted by
Ken Campbell
Robert Seaborne
3 months ago
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, Iβm hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
0
6
5
Lovely profile of Mindy Thompson, one of our lab's great alumni.
medicine.uky.edu/news/saying-...
loading . . .
Saying yes to opportunity: How Mindy Thompson built a career at UK
https://medicine.uky.edu/news/saying-yes-opportunity-how-mindy-thompson-built-2025-10-27t14-27-33
3 months ago
0
2
0
On behalf of our team at
@ukresearch.bsky.social
, highlighting "Patients who donate biospecimens for research leave a valuable and underappreciated scientific legacy". We can all remember that behind every data point is a person, a family, and a story.
www.ahajournals.org/eprint/8HECU...
loading . . .
American Heart Association Journals
https://www.ahajournals.org/eprint/8HECUBWKWGMGRJRXMDH4/full?redirectUri=%2Fdoi%2F10.1161%2FCIRCHEARTFAILURE.125.013242
4 months ago
0
1
1
reposted by
Ken Campbell
American Physiological Society
4 months ago
Congrats to new
#NobelLaureates
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries of peripheral immune tolerance and T reg cells. Read more: https://ow.ly/aiHn50X74mS
#NobelPrize
#Physiology
1
14
5
reposted by
Ken Campbell
4 months ago
A recent article in Circulation Research highlights findings from the van Berlo research lab, indicating that the cytoskeletal protein Septin4 plays a role in the onset of cardiac fibrosis by modifying the function of calcineurin. Read the full article:
buff.ly/EUNsdKG
#UMNresearch
#Cardiosky
0
1
2
Delighted to see myocardial samples donated by patients and organ donors at
@ukresearch.bsky.social
supporting another important publication. Thank you for the opportunity to contribute.
academic.oup.com/cardiovascre...
loading . . .
RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure
AbstractAims. Heart failure with reduced ejection fraction (HFrEF) is a major health problem. Increasing L-type calcium channel (LTCC) activity deteriorate
https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvaf169/8270769?utm_source=authortollfreelink&utm_campaign=cardiovascres&utm_medium=email&guestAccessKey=8cae8a6f-fe85-45cd-9b2e-04fb1a61f237
4 months ago
1
4
0
reposted by
Ken Campbell
Lyssiotis Lab
5 months ago
Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists
jobs.sciencecareers.org/job/674815/a...
loading . . .
Assistant/Associate Professor - Tenure Track - Physiology - University of Michigan, Ann Arbor job with University of Michigan Department of Molecular & Integrative Physiology | 674815
Tenure track assistant/associate professor in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School.
https://jobs.sciencecareers.org/job/674815/assistant-associate-professor-tenure-track-physiology/
0
23
17
reposted by
Ken Campbell
Brian Umberger
5 months ago
Please repost! We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus.
#BiomechSky
loading . . .
Tenure-track Faculty Position in Biomechanics (Open Rank), University of Michigan, Ann Arbor, MI, USA - Biomch-L
The School of Kinesiology (http://kines.umich.edu) at the University of Michigan invites applications and nominations for a tenure-track faculty position at the level of Assistant Professor, Associate...
https://biomch-l.isbweb.org/forum/biomch-l-forums/jobs-and-positions/49048-tenure-track-faculty-position-in-biomechanics-open-rank-university-of-michigan-ann-arbor-mi-usa
0
36
65
reposted by
Ken Campbell
5 months ago
#musclesyneRgies
1.2.5.9009 (development version) How to install πππππππ.ππππππππ("πππππππ") πππππππ::πππππππ_ππππππ("πππππππππ£/ππππππππ’πππππππ") Improved function CoA with non-duplicated angles and robust quadrant handling. Please update!
#rstats
#opensource
github.com/alesantuz/mu...
0
7
4
GelBox - reproducible analysis of gels and immunoblots
campbell-muscle-lab.github.io/GelBox/
pubmed.ncbi.nlm.nih.gov/39092999/
5 months ago
1
2
0
Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action.
www.pnas.org/doi/10.1073/...
Excited to see our FiberSim code being put to such good use.
campbell-muscle-lab.github.io/FiberSim/
loading . . .
Danicamtiv reduces myosinβs working stroke but activates the thin filament by accelerating actomyosin attachment | PNAS
Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As...
https://www.pnas.org/doi/10.1073/pnas.2515786122
5 months ago
0
4
1
reposted by
Ken Campbell
Glen Pyle | Womens Heart Health β€οΈβπ©ΉποΈ
5 months ago
Can you really repair an engine while it's running? π©π½βπ§ The heart can. πͺπΌπ« Our latest
@faseborg.bsky.social
paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. βΉπΌββοΈπββοΈ
#Exercise
#Heart
#Muscle
#BasicScience
#Cardiology
faseb.onlinelibrary.wiley.com/doi/10.1096/...
loading . . .
Cardiac CapZ Regulation During Acute Exercise in Female Mice
CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During...
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502431R
1
11
5
reposted by
Ken Campbell
Anna Kate Barton
5 months ago
Always exciting to see new HF agents in development! I enjoyed reading this interesting study using porcine model of HF with some promising outcomes for MiR-132. Available now in
@escardio.bsky.social
journal EHJ-IMP:
academic.oup.com/ehjimp/artic...
loading . . .
MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling
AbstractAims. Cardiac miR-132 has been proposed as a target for heart failure (HF) therapy. CDR132L, a rationally designed synthetic oligonucleotide inhibi
https://academic.oup.com/ehjimp/article/3/2/qyaf088/8221512?searchresult=1
0
3
3
reposted by
Ken Campbell
Robert Seaborne
6 months ago
Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!
add a skeleton here at some point
2
11
3
Another great paper from Dan Beard's group at
@umich.edu
addressing measurements of the SRX / IHM / OFF state in myosin.
www.biorxiv.org/content/10.1...
loading . . .
Kinetic Modeling of mant-ATP Turnover to Interpret the Biochemically Defined Myosin Super-Relaxed State
The fluorescent ATP analog mant-ATP has become a valuable tool for quantifying occupancy of the myosin super-relaxed (SRX) state, a biochemically inactive conformation of myosin in striated muscle. In...
https://www.biorxiv.org/content/10.1101/2025.08.06.667936v1
6 months ago
0
1
0
More great research at
@ukresearch.bsky.social
uknow.uky.edu/research/qa-...
loading . . .
Q&A with Caroline Geisler: Exploring new path to weight loss β minus side effects
The most effective obesity medications of today β GLP-1 drugs such as Ozempic and Wegovy β come with significant side effects, most commonly nausea and vomiting. Researchers in the UK College of Pharm...
https://uknow.uky.edu/research/qa-caroline-geisler-exploring-new-path-weight-loss-minus-side-effects
6 months ago
0
0
0
uknow.uky.edu/uk-healthcar...
loading . . .
Keeneland investigator finds healing and humor in heart surgery at UK
On an early morning drive to Keeneland, Billy Fryer felt a pain in his chest he had never felt before. Thanks to UK HealthCareβs partnership with Keeneland and the compassionate work of his care team,...
https://uknow.uky.edu/uk-healthcare/keeneland-investigator-finds-healing-and-humor-heart-surgery-uk
6 months ago
0
0
0
Excited to be working with Jonathan Wenk (University of Kentucky) and Lik-Chuan Lee (Michigan State University) on computer modeling of cardiac fibrosis.
uknow.uky.edu/research/uk-...
loading . . .
UK engineering researcher leads NSFβfunded initiative to model heart fibrosis with machine learning
Researchers in the Stanley and Karen Pigman College of Engineering at the University of Kentucky are teaming up with researchers at Michigan State University to develop cutting-edge simulations of hea...
https://uknow.uky.edu/research/uk-engineering-researcher-leads-nsf-funded-initiative-model-heart-fibrosis-machine-learning
6 months ago
0
2
0
reposted by
Ken Campbell
Center For Cardiometabolic Science
6 months ago
π TRPA1-derful news π Dr. Dan Conklin has been successful in obtaining AHA funding to explore how inhaled anesthetics affect cardiorespiratory function through Transient Receptor Potential Ankyrin-1 (TRPA1).
#AHA
#TeamConklin
#TRPA1
#cardiosky
@ahascience.bsky.social
@uoflenvirome.bsky.social
0
8
3
reposted by
Ken Campbell
Daniel P. Ferris
7 months ago
Great talk by Greg Sawicki at
#AMAM2025
on tuning series elastic stiffness (e.g. tendon) in legged locomotion.
0
6
1
reposted by
Ken Campbell
Center For Cardiometabolic Science
7 months ago
Congratulations to Dr. Marcin Wysoczynski, Associate Professor in the Center, on his appointment to the Editorial Board of Circulation Research. Well done, Dr. Wysoczynski.
@ahajournals.bsky.social
#cardiosky
0
5
3
reposted by
Ken Campbell
Julien Ochala
7 months ago
Our department
@ucph.bsky.social
is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!
loading . . .
164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences
https://jobportal.ku.dk/videnskabelige-stillinger/?show=164414
0
12
7
Congrats to Drs. Kampourakis, McDonald, Root and their collaborators on this cool study. Always excited to see new modulators of sarcomere function. Modulation of striated-muscle contractility by a high-affinity myosin-targeting peptide: Biophysical Journal
www.cell.com/biophysj/ful...
loading . . .
Modulation of striated-muscle contractility by a high-affinity myosin-targeting peptide
Myosin-based regulation has emerged as a fundamental new concept governing both cardiac and skeletal muscle contractile function during both health and disease states. Myosin-targeted therapeutics hav...
https://www.cell.com/biophysj/fulltext/S0006-3495%2825%2900322-4
7 months ago
0
3
0
reposted by
Ken Campbell
Helen Collins
7 months ago
The Collins lab welcomed Nora Anderson to the team today. Nora joins as a research technician, who will assist with our ongoing pregnancy studies. π«π€°#cardiosky
0
5
1
reposted by
Ken Campbell
Helen Collins
7 months ago
Congratulations to Avery Kendall for their first of many papers being accepted for publication today. Watch this space for the next one!
#cardiosky
@apspublications.bsky.social
0
9
3
reposted by
Ken Campbell
Aurora Scientific
8 months ago
Aurora Scientific is
#hiring
a Life Science Product Consultant. This position is dedicated to building and maintaining a lasting relationship with our customers by conducting sales and post-sales support activities. Apply now!
ca.indeed.com/viewjob?jk=6...
0
3
3
reposted by
Ken Campbell
Helen Collins
8 months ago
Helping to raise awareness for womenβs cardiovascular health at the 2025 Kentuckiana AHA Go Red For Women Luncheon
@ahascience.bsky.social
1
11
5
uknow.uky.edu/uk-healthcar...
loading . . .
UK HealthCare marks 600 life-changing heart transplants
https://uknow.uky.edu/uk-healthcare/uk-healthcare-marks-600-life-changing-heart-transplants
8 months ago
0
3
0
reposted by
Ken Campbell
Avery Hinks
8 months ago
If interested, each chapter of my thesis can be read in these publicationsβ¦ Literature review: βThe importance of serial sarcomere addition for muscle function and the impact of agingβ
journals.physiology.org/doi/full/10....
loading . . .
The importance of serial sarcomere addition for muscle function and the impact of aging | Journal of Applied Physiology | American Physiological Society
During natural aging, skeletal muscle experiences impairments in mechanical performance due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross-sectional area (CS...
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00205.2023?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
1
9
3
reposted by
Ken Campbell
Helen Collins
8 months ago
Probably do not need another social media account but for those who wish to follow a photographic journey of the Collins lab, we now have a lab Instagram page.
#cardiosky
1
9
1
reposted by
Ken Campbell
Rebekah Gundry
8 months ago
Really looking forward to this opportunity and experience!
add a skeleton here at some point
2
7
3
reposted by
Ken Campbell
The BMJ
8 months ago
Hypertrophic cardiomyopathy is a common yet under-recognised genetic structural heart condition. This review provides a critical analysis of the rapidly evolving and wide ranging therapeutic landscape in hypertrophic cardiomyopathy
www.bmj.com/content/389/...
1
13
5
reposted by
Ken Campbell
Dave Barefield
8 months ago
Today's XKCD is a great excuse to plug Loyola's
@loyolachicago.bsky.social
Master of Science in Clinical and Applied Proteomics:
www.luc.edu/stritch/cell...
#massspec
@jonathankirk.bsky.social
0
6
2
Welcoming Susma Sah, a biology freshman, to our lab for a summer research experience. She's already grant-funded!
uknow.uky.edu/research/16-...
loading . . .
16 students awarded CURE Fellowships
https://uknow.uky.edu/research/16-students-awarded-cure-fellowships
8 months ago
0
4
0
Huge thanks to all who help drive clinical research at the University of Kentucky and around the world.
uknow.uky.edu/research/cli...
loading . . .
Clinical trials make discovery happen at UK
May 20 is Clinical Trials Day, which commemorates the day that James LindΒ began the first randomized clinical trial in 1747.
https://uknow.uky.edu/research/clinical-trials-make-discovery-happen-uk
8 months ago
0
1
0
reposted by
Ken Campbell
bioRxiv Physiology
9 months ago
Old mice have a functionally distinct contractile reserve from obese mice
https://www.biorxiv.org/content/10.1101/2025.05.13.653770v1
0
2
1
reposted by
Ken Campbell
Nixa Sedes, MD
8 months ago
Efficacy of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Mild Symptoms: Results from the SEQUIOA-HCM Trialπ
academic.oup.com/eurheartj/ad...
loading . . .
Efficacy of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Mild Symptoms: Results from the SEQUIOA-HCM Trial
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf364/8133640
0
3
3
reposted by
Ken Campbell
Will Fuller
9 months ago
Well hereβs an exciting opportunity! Who wants to spend 5 years working on S-acylation as part of a fantastic multidisciplinary team?
#acylation
#cellbiology
#glasgow
www.jobs.ac.uk/job/DNB111/r...
loading . . .
Research Assistant/Associate at University of Glasgow
Apply for the Research Assistant/Associate role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
https://www.jobs.ac.uk/job/DNB111/research-assistant-associate
0
11
4
reposted by
Ken Campbell
Kerstin Blank
9 months ago
We have a
@fwf-at.bsky.social
doc.funds PhD position
@jku.at
! Join us to study how cells sense forces and develop molecular force sensors. Apply by May 31, 2025. For details and instructions go to
www.jku.at/en/institute...
#PhDposition
#Biophysics
#Mechanobiology
#CellMechanics
#AcademicJobs
0
11
11
reposted by
Ken Campbell
Manchester BHF Centre of Research Excellence
9 months ago
We have some exciting opportunities for aspiring researchers! Fully funded BHF studentships in interdisciplinary cardiovascular research. Deadline to apply is 6th June
#PhD
#studentships
www.bmh.manchester.ac.uk/study/resear...
loading . . .
British Heart Foundation Centre of Research Excellence Studentships
Find out more about the British Heart Foundation Centre of Research Excellence Studentships available for cardiovascular research.
https://www.bmh.manchester.ac.uk/study/research/funding-fees/funded-programmes/bhf-cre-studentships/
1
3
6
reposted by
Ken Campbell
plus.maths.org
9 months ago
Yesterday was Florence Nightingale's birthday! To see a brief introduction to Nightnigale the statistician see
plus.maths.org/content/intr...
For a more detailed look see
plus.maths.org/content/flor...
#maths
#mathematics
#statistics
0
8
4
reposted by
Ken Campbell
Rafeeque Mavoor
9 months ago
π§΅5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
32
677
355
Congrats to all the authors. This looks fantastic and a real breakthrough.
add a skeleton here at some point
9 months ago
1
3
0
Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins. Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...
9 months ago
4
11
2
reposted by
Ken Campbell
Lars MΓΈlgaard Saxhaug
9 months ago
Keep recommending this excellent paper on principles and practical use of Bayesian statistical methods for clinicians
#emimcc
#cardiosky
www.atsjournals.org/doi/10.1164/...
@fgzamp.bsky.social
@f2harrell.bsky.social
loading . . .
Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial | American Journal of Respiratory and Critical Care Medicine
Most randomized trials are designed and analyzed using frequentist statistical approaches such as null hypothesis testing and P values. Conceptually, P values are cumbersome to understand, as they provide evidence of data incompatibility with a null hypothesis (e.g., no clinical benefit) and not direct evidence of the alternative hypothesis (e.g., clinical benefit). This counterintuitive framework may contribute to the misinterpretation that the absence of evidence is equal to evidence of absence and may cause the discounting of potentially informative data. Bayesian methods provide an alternative, probabilistic interpretation of data. The reanalysis of completed trials using Bayesian methods is becoming increasingly common, particularly for trials with effect estimates that appear clinically significant despite P values above the traditional threshold of 0.05. Statistical inference using Bayesian methods produces a distribution of effect sizes that would be compatible with observed trial data, interpreted in the context of prior assumptions about an intervention (called βpriorsβ). These priors are chosen by investigators to reflect existing beliefs and past empirical evidence regarding the effect of an intervention. By calculating the likelihood of clinical benefit, a Bayesian reanalysis can augment the interpretation of a trial. However, if priors are not defined a priori, there is a legitimate concern that priors could be constructed in a manner that produces biased results. Therefore, some standardization of priors for Bayesian reanalysis of clinical trials may be desirable for the critical care community. In this Critical Care Perspective, we discuss both frequentist and Bayesian approaches to clinical trial analysis, introduce a framework that researchers can use to select priors for a Bayesian reanalysis, and demonstrate how to apply our proposal by conducting a novel Bayesian trial reanalysis.
https://www.atsjournals.org/doi/10.1164/rccm.202006-2381CP
0
10
5
Excited to contribute to Thomas Kampourakis's latest work on cardiac thick filament mechano-sensing.
www.biorxiv.org/content/10.1...
loading . . .
Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechano-sensing
The heart can adapt its performance in response to changing metabolic demands of the rest of the body. A central mechanism intrinsic to the heart is to modulate the function of the cardiac contractile...
https://www.biorxiv.org/content/10.1101/2025.04.25.650613v1
9 months ago
0
2
1
reposted by
Ken Campbell
Julien Ochala
9 months ago
If interested in cardiac biology, we have a MSc thesis project in our lab at
@ucph.bsky.social
this is (in my mind) a good project for an Erasmus student!
0
4
5
reposted by
Ken Campbell
Solis Lab @ FSU
10 months ago
π«β‘We are pleased to share our first review from the lab published in
@apsphysiology.bsky.social
! Here we dive deep into how mechanical forces transduce into biochemical signals that coordinate cardiac cell growth and heart adaptation. Access manuscript here β
journals.physiology.org/doi/full/10....
0
3
1
Load more
feeds!
log in