#EHJCVI 🫀 Can RV myocardial work help identify PAH patients at higher risk? 📊 RV global wasted work correlates with mPAP, PVR, SVC, and PAC, with higher values in high-risk groups. A cut-off >175 mmHg% is associated with mortality ⚠️ Read more: doi.org/10.1093/ehjc...#EHJCVI#MedSky #Echofirst

Er det noe jeg har misforstått, eller er fokuset på kunnskapsministeren helt meningsløst? Er ikke dette en sak om at en Frp-styrt kommune driver Frp-politikk? www.nrk.no/sorlandet/ku...

Wow, "My neighbour, Totoro" was absolutely stunning, just as much a wonderful experience for the one of us who had never seen the film as for the rest of us!

Patient with cirrhosis and INR of 3 needs a procedure Please step away from the FFP EVERY guideline & article agrees that FFP shouldn't be given for pre-procedure coag optimization (even high-risk procedures) Plt & fibrinogen are more controversial Discussion emcrit.org/ibcc/cirrhos... #EMIMCC

It's lucky the UK doesn't have any key industries or services reliant on this kind of immigration. *checks notes* Oh...

Why does every target trial emulation study have to include a bit that says "this shows how great target trial emulation is. RCTs are non-generalisable and expensive"? Imagine if every RCT said "this shows how great RCTs are. We did not have to rely on strong, untestable assumptions".

Snart på tide å begynne å snakke om ei skikkelig krise i akademia. Dette er den naturlige endestasjonen til det stadig akselererende toget vi sitter på.

To mark Proof being an FT Book of the Year, I’m giving away 2 copies in run up to Xmas – prize will go to the quirkiest, funniest, or most interesting Christmas-related science.
 Comment below – most likes by 8th Dec wins (Europe/US only). To kick things off, here's Galton's 1906 Nature letter:

There are two kinds of people in this world

What’s going on here with the right ventricle? Answer in the 🧵 #cardiosky #echofirst

Just saying #StatsSky #rstats #Statistics

Apixaban and warfarin being similar is also a red flag And with LAOO is such a huge selection bias The SAFE-D trial (pilot; pubmed.ncbi.nlm.nih.gov/39495569/) is now funded to examine apixaban properly #NephSky

I’m happy that my PhD time will count at some point in my life. Or death.

Propensity score methods are no match for strong confounding by indication, this needs a proper prospective randomised controlled study. www.jacc.org/doi/10.1016/... #cardiosky #medsky

Could this possibly be VACCINE-related?

I kjølvannet av at jeg fikk Humanistprisen 2025 har jeg snakket med Kaja Melsom i podkasten Kriseklubben, i regi av Human-Etisk Forbund, om hvordan russisk propaganda og narrativer sprer seg i norsk offentlighet – ofte uten at vi merker det. Lenker i 🧵. 1/5

Interesting editorial on the distinction between statistical and clinical significance. Any thoughts from #statsky and #metascience?

Delirium in ICU patients, particularly hyperactive delirium, remains challenging. While dexmedetomidine has shown potential for agitation control, the trial results indicate limited evidence for delirium resolution or prevention of intubation. zurl.co/0fvtR

vet ikke jeg vedum, dagens olje-og gasspolitikk er et ganske heftig eksperiment med fatale konsekvenser det og

Skam Skam Skam Skam

Forskninga OUS har utført på transpersoner burde fått de etiske alarmklokkene til å ringe så høyt at Gondor kom til unnsetning. Hvorfor er forskerne FORTSATT inne og titter i journalene deres, senest i september? Her bør det komme følger både for forskninga & tilgang www.forskning.no/forskningset...

Husk at om du har en dårlig dag så er det bare å sette på vinnertalen til Zohran Mamdani igjen og alt blir bra

Det jeg syns er rart er at det stadig påpekes ovenfor MDG at "dagens oljepolitikk har flertall i stortinget", mens ingen påpeker at klimaloven også ble vedtatt med bredt flertall i stortinget. Det er sjukt at MDG må kjempe som løver for å få de andre partiene med på å nå mål _de selv har lovfestet_.

Selvfølgelig må NRK legge ned det siste de hadde av kulturjournalistikk fordi de må satse på mer Plaskorama og Fetisha og promp og bæsj, vi er da ikke Nord-Korea heller

“Long-Term Continuous Monitoring of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting.” Publié ce jour dans @jama.com. #MedSky #CardioSky jamanetwork.com/journals/jam...

I was interviewed by the wonderful journalist @melodyschreiber.com for this piece—which focuses on the REAL story: Nuzzi “used her position of power, as a journalist, to advise and elevate the world’s most prominent anti-vaccine activist to the most influential health position in the United States”

😍😍😍

"we probably do not need to worry about the fact that the actual effect of one treatment rather than the other is not the same for all patients. Quite limited knowledge about an average improvement is the best that we can do" John Tukey, Controlled Clinical Trials, 1993 p282

Politiet i Trondheim vil ikke prioritere trygg trafikk. Og Trond Volden får gå rundt som han vil. Politiet i Trondheim scorer full pott.

Skremmende opptreden fra politiet på høring om samferdselsplanen i Trondheim i dag. De opptrer som politisk aktør i debatten om gjennomkjøringa i Midtbyen. Varsler at de ikke kommer til å håndheve skilting i Midtbyen fordi den er "komplisert" og at de ikke prioriterer skilting for kjøremønster.

Høring om samferdselsplanen i Trondheim. Politiet kommer med klassisk "vi liker ikke skiltene, vi kommer ikke til å håndheve her", og blir avkledd av en Ap-politiker. Politiet tydelig irritert. Stor underholdning.

“I have been using a combination of cap refill and MAP since the original ANDROMEDA SHOCK paper” Justin explores the many limitations of this trial but then admits that he does use CRT as a resus target. I fundamentally agree. Implementing imperfect data into practice is complicated. #EMIMCC

Trimethoprim-sulfamethoxazole carries a very low (but real) risk of causing ARDS. Duration of therapy is a risk factor (>7 days). Could likely be minimized by avoiding unnecessarily long courses. TMP-SMX is usually well tolerated, but can wreak havok (SJS, ARDS, drug-induced meningitis). #EMIMCC

I swore an oath to the Constitution in 1986. I've upheld it through 25 years of service and every day since I retired. If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.

Here we go again. I am begging skribenter i norske aviser om å tenke seg om før de sier ting som “vant over“ eller “tapte kampen“ når de snakker om kreft. Folk overlever ikke kreft fordi de kjempa hardere enn de som døde av det.

Breaking: Viola Ford Fletcher, the oldest living survivor of the 1921 Tulsa Race Massacre, has died. She was 111 years old

Forskning: Jo sterkere offentlige medietjenester, jo sunnere demokrati. Kan vi legge debatten om å defunde NRK og strupe pressestøtten død nå?

Am walking through Holland Park in London and a peacock crossed my path

Oh dear The Great Barrington Declaration argued vociferously, in their campaign of support for RFK Jr, that RFK Jr, would boost trust in vaccines Whoever could have predicted that the GBD was talking dangerous anti-scientific nonsense?

they are not playing 3D chess. they are fucking idiots.

Fedt! nyheder.tv2.dk/live/kort-ny...

Om kutt i stipend for folkehøgskuleelevar: "Det kan spare staten en million kroner" Som om ikkje det vil gi fleire unge på AAP og på DPS. Eg TRYGLAR om at politikarane byrjar å sjå heile biletet når dei snakkar om pengar.

Jeg hadde tenkt å skrive en tråd om ultraprosesert mat, men Anders har sagt nesten alt jeg ville. Det jeg vil legge til er at hele ernæringsepidemiologien sliter enormt med at de som rapporterer å spise på en viss måte, lever annerledes på så mange andre måter også.

Det er noe… «faglig» som skurrer litt for meg i denne nyhetssaken og debatten som har fulgt siste uka, og skal prøve å forklare hva. www.vg.no/i/lngVKy?utm...

Ian Miles Cheong: Everyone must go back to the country where they are born. Please don't tell people I'm living in Malaysia, where I was born, but spend my entire life complaining about America. Ian Miles Cheong: *has been secretly living in Dubai this whole time*

Tja, mistenker jeg kan slå den. En foreleser jeg hadde på Blindern mista sin emeritus-kontorplass på grunn av avsporet forskning inn i konspiland.

So I’ve watched a couple of videos lately. 1. This one on UK debt, bonds and interest (Gary’s Economics): youtu.be/YeH5UXYEzPE 2. And this one where Jeffrey Gundlach goes into similar things for the US: youtu.be/n7JV_DaBFXk?... Iiuc they are both saying that the current trajectory is unsustainable.

CASSIDY: I know it's titillating, but I think we need to move beyond the titillation TAPPER: This isn't about titillation. This is about the fact that you are the chairman of the health committee and you voted to confirm somebody that by all accounts is actually making America less healthy

Do you have the time to listen to me whine? About nothing and everything, all at once I am one of those melodramatic fools Neurotic to the bone, no doubt about it