Intracellular Mechanosensation in Intestinal Smooth Muscle: Piezo1 Complexes Amplify Signaling Beyond the Surface https://www.biorxiv.org/content/10.64898/2026.02.19.706403v1

Brain-derived ketone bodies can replace glucose to power neural function https://www.biorxiv.org/content/10.64898/2026.02.19.706813v1

Sex-specific electrophysiology and cholinergic responses underlie differential mechanisms of arrhythmia vulnerability in rabbit atria https://www.biorxiv.org/content/10.64898/2026.02.18.706701v1

Phosphoproteomics of Hypertrophic Cardiomyopathy Patient Myocardium and Novel hiPSC-CM Model Reveal Protein Kinase A as a Modulator of Microtubule Repolymerization https://www.biorxiv.org/content/10.64898/2026.02.18.706710v1

Cardiac PIEZO 1 Channels Modulate Anxiety https://www.biorxiv.org/content/10.64898/2026.02.18.706706v1

Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction https://www.biorxiv.org/content/10.64898/2026.02.19.706806v1

Redox-activated induction of Warburg-type metabolism in the adult heart https://www.biorxiv.org/content/10.64898/2026.02.18.706512v1

Inducible Impairment of Polymerase Gamma Activity in Cardiomyocytes Promotes Severe Cardiomyopathy with Cardiac Hepatopathy https://www.biorxiv.org/content/10.64898/2026.02.17.706486v1

A Regionally Inspired West Virginia Obesogenic Diet Induces Fat Accretion and Metabolic Dysfunction While Identifying Sex Disparity https://www.biorxiv.org/content/10.64898/2026.02.16.706140v1

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse https://www.biorxiv.org/content/10.64898/2026.02.16.706166v1

Lysosomal abundance in young and aged mouse hearts assessed by In Vivo Imaging Systems (IVIS) Lysotracker imaging and autophagy-related gene expression https://www.biorxiv.org/content/10.64898/2026.02.16.706145v1

The Strehler-Mildvan mortality correlation arises from changes in the variability of ageing https://www.biorxiv.org/content/10.64898/2026.02.15.705972v1

Sociality, diurnal temperature range and isothermality: Significant determinants of mass-independent resting metabolic rate in subterranean African mole-rats (Superfamily Bathyergidae) https://www.biorxiv.org/content/10.64898/2026.02.13.705831v1

Tirzepatide improves pancreatic β-cell function in mice and patients with type 2 diabetes. https://www.biorxiv.org/content/10.64898/2026.02.13.704343v1

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism https://www.biorxiv.org/content/10.64898/2026.02.12.705648v1

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance https://www.biorxiv.org/content/10.64898/2026.02.11.705361v1

Characterization of transcriptomic profiles underlying gross morphological changes observed in semelparous pink salmon (Oncorhynchus gorbuscha) https://www.biorxiv.org/content/10.64898/2026.02.12.705573v1

Thirty days of supplementation with PQQ reprograms immunometabolic networks in Western diet-fed female baboons https://www.biorxiv.org/content/10.64898/2026.02.12.705540v1

Modeling Fast CICI Calcium Waves https://www.biorxiv.org/content/10.64898/2026.02.12.705545v1

Propionate oxidation by Geobacter sulfurreducens is electron acceptor dependent https://www.biorxiv.org/content/10.64898/2026.02.11.701306v1

Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions https://www.biorxiv.org/content/10.64898/2026.02.12.705530v1

Resident cardiac macrophages are not required for normal atrioventricular node conduction https://www.biorxiv.org/content/10.64898/2026.02.11.704506v1

Multimodal mechano-SICM and FRET with stretch for probing cardiomyocyte function. https://www.biorxiv.org/content/10.64898/2026.02.11.705278v1

Testosterone alleviates inflammation but increases the methacholine response in mice with allergic lung inflammation https://www.biorxiv.org/content/10.64898/2026.02.10.705120v1

A Kidney Stone Associated CLDN4 Variant Impairs Tight Junction Stability and Paracellular Ion Permeability https://www.biorxiv.org/content/10.64898/2026.02.10.705174v1

Type A Intercalated Cell Dysfunction Disrupts Renal Epithelial/Immune Balance and Impairs Host Defense During UTI https://www.biorxiv.org/content/10.64898/2026.02.10.705112v1

A Physiologically Constrained Calibration Framework for Cardiovascular Models applied in Paediatric Sepsis https://www.biorxiv.org/content/10.64898/2026.02.10.704842v1

Phthalate exposure induces inflammatory signaling and alters mitochondrial respiration in marine mammal and human cells https://www.biorxiv.org/content/10.64898/2026.02.09.704935v1

Chronic Paraventricular OX1R Overexpression Induces Oxidative Stress and Hypertension in Rats https://www.biorxiv.org/content/10.64898/2026.02.09.704927v1

Eicosapentaenoic Acid Enhances Angiogenesis and Reperfusion After Ischemia: Comparative Effects of Omega-3 Fatty Acids in a Murine Hind Limb Model https://www.biorxiv.org/content/10.64898/2026.02.09.704971v1

Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation in Nothobranchius furzeri. https://www.biorxiv.org/content/10.64898/2026.02.09.704879v1

Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure https://www.biorxiv.org/content/10.64898/2026.02.06.704519v1

Subcellular proteomic profiling of human skeletal muscle reveals exercise-induced coordinated and compartment-specific protein remodeling https://www.biorxiv.org/content/10.64898/2026.02.08.703653v1

Flexibility of systemic one-carbon metabolism partially buffers dietary methyl donor deficiency https://www.biorxiv.org/content/10.64898/2026.02.05.703880v1

A translational porcine model to assess the graded impact of hemorrhage and aortic occlusion on cardiovascular hemodynamics and renal perfusion https://www.biorxiv.org/content/10.64898/2026.02.05.703869v1

Small-molecule targeting MuRF1 enhances functional exercise capacity in rats: an exploratory study https://www.biorxiv.org/content/10.64898/2026.02.05.704003v1

c-MAF transduces motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions https://www.biorxiv.org/content/10.64898/2026.02.05.703983v1

Maternal Obesity Decreases Offspring Lifespan https://www.biorxiv.org/content/10.64898/2026.02.04.703858v1

Electrostatic facilitation of odorant capture in insects https://www.biorxiv.org/content/10.64898/2026.02.04.703773v1

Lipidomic and metabolomic profiling on low count human spermatozoa: A robust and reproducible method for untargeted HPLC-ESI-MS/MS-based approach https://www.biorxiv.org/content/10.64898/2026.02.04.703749v1

A semantic segmentation model to predict subcellular glycogen localization using transmission electron microscopy images https://www.biorxiv.org/content/10.64898/2026.02.04.703703v1

Demonstration of periodic and aperiodic EEG reliability between laboratory and clinic settings https://www.biorxiv.org/content/10.64898/2026.02.03.703614v1

Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption https://www.biorxiv.org/content/10.64898/2026.02.03.703579v1

Frogs uncouple neural activity from oxygen consumption after hibernation https://www.biorxiv.org/content/10.64898/2026.02.03.703589v1

A regulatory role of novel long non-coding RNA, BAZ1A-AS1, in vascular smooth muscle cell functions during neointima formation in human saphenous veins https://www.biorxiv.org/content/10.64898/2026.02.03.703576v1

Cognate amino acid therapies provide preclinical benefit in 19 C. elegans models of ARS2 deficiency https://www.biorxiv.org/content/10.64898/2026.02.03.703549v1

SIX1-dependent myofiber typology and metabolism controls muscle hypertrophy https://www.biorxiv.org/content/10.64898/2026.02.03.703490v1

Neural and mechanical properties of vastus lateralis and vastus medialis at different rectus femoris muscle lengths https://www.biorxiv.org/content/10.64898/2026.02.03.703444v1

iMyocyte: A Web-Based Cellular Automata Platform for Real-Time Demonstration of Cardiac Reentry https://www.biorxiv.org/content/10.64898/2026.02.02.703157v1

Exercise Intensity Modulates the Validity of Non-Linear Heart Rate Time Series Analysis Window Length: Implications for DFAa1 Monitoring https://www.biorxiv.org/content/10.64898/2026.02.02.703217v1