Plasma metabolite responses to an oral protein tolerance test differ between young and sarcopenic participants and suggest altered anabolic sensitivity https://www.biorxiv.org/content/10.64898/2026.06.29.735267v1

An optimized "hypoxia in a pill" regimen reverses neurodegenerative disease phenotypes in multiple preclinical models https://www.biorxiv.org/content/10.64898/2026.06.30.734089v1

Lung hypoperfusion stimulates liquid absorption in alveoli https://www.biorxiv.org/content/10.64898/2026.06.29.735362v1

PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current https://www.biorxiv.org/content/10.64898/2026.06.29.735321v1

Oxytocin-like signaling couples reproductive state to intestinal lipid metabolism in aging C. elegans https://www.biorxiv.org/content/10.64898/2026.06.28.735098v1

Hepatic Cholesteryl Ester Transfer Protein Regulates Sex-specific Liver Metabolic Adaptation and Metabolic-Associated Steatotic Liver Disease Risk in Diet-induced Obesity https://www.biorxiv.org/content/10.64898/2026.06.28.735072v1

Fentanyl-Induced Diaphragmatic Discoordination during Overdose https://www.biorxiv.org/content/10.64898/2026.06.28.734963v1

Deletion of GPR39 Prevents Pulmonary Arterial Hypertension by Attenuating Hypoxia-Induced Aberrant Signaling https://www.biorxiv.org/content/10.64898/2026.06.27.735008v1

The Ca2+-Sensitivity of Contraction is Increased in the Left Atrium and Left Ventricle of Patients with Ischemic Heart Failure https://www.biorxiv.org/content/10.64898/2026.06.26.734899v1

Unilateral resistance training induces greater rate coding adaptations in high-threshold motor units during maximal voluntary contractions https://www.biorxiv.org/content/10.64898/2026.06.26.734811v1

Endothelial Baf60c in BPD-Associated Pulmonary Hypertension https://www.biorxiv.org/content/10.64898/2026.06.26.734924v1

Dietary Sodium Deprivation Remodels the Serum Lipidome and Reveals Systemic Metabolic Adaptation in Rats https://www.biorxiv.org/content/10.64898/2026.06.26.734806v1

Conserved and diverged patterns of senescence in Pristionchus nematodes https://www.biorxiv.org/content/10.64898/2026.06.26.734768v1

Cardiovascular Benefits of Menopause Hormone Treatment is Age-Dependent https://www.biorxiv.org/content/10.64898/2026.06.29.734522v1

Can exercise training improve mitochondrial thermal responses in rainbow trout cardiomyocytes? https://www.biorxiv.org/content/10.64898/2026.06.26.734741v1

Diel metabolic variation and the energetic demands of courtship in bioluminescent Photeros ostracods https://www.biorxiv.org/content/10.64898/2026.06.25.734310v1

β-cell-specific Ahr expression is critical to high-fat diet-induced hyperinsulinemia https://www.biorxiv.org/content/10.64898/2026.06.25.734641v1

Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development https://www.biorxiv.org/content/10.64898/2026.06.25.734607v1

MicroRNA regulation of stress-survival signalling and protein quality control in human heatstroke https://www.biorxiv.org/content/10.64898/2026.06.25.734416v1

Dietary protein source dictates the impact of obesogenic diets on hepatic steatosis and insulin resistance via carnitine-dependent regulation of acetyl-CoA carboxylase https://www.biorxiv.org/content/10.64898/2026.06.25.732886v1

A time-dependent mechano-bioenergetics model of muscle contraction https://www.biorxiv.org/content/10.64898/2026.06.24.734405v1

Cellular uptake of Micro and nano plastics Induces Mitochondrial Dysfunction https://www.biorxiv.org/content/10.64898/2026.06.24.734306v1

PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity. https://www.biorxiv.org/content/10.64898/2026.06.24.734313v1

Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice https://www.biorxiv.org/content/10.64898/2026.06.24.734270v1

IP3R-TRPM4 Coupling Determines the Spatial Reach of Pericyte-Mediated Capillary Constriction https://www.biorxiv.org/content/10.64898/2026.06.24.734288v1

Resident myeloid-derived immune cells contribute to early lipopolysaccharide-induced cytokine secretion in mouse soleus muscle https://www.biorxiv.org/content/10.64898/2026.06.23.734036v1

Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity https://www.biorxiv.org/content/10.64898/2026.06.23.734002v1

Tirzepatide attenuates atherosclerosis through weight loss-independent anti-inflammatory mechanisms https://www.biorxiv.org/content/10.64898/2026.06.22.733886v1

Leptin alleviates obesity hypoventilation via serotonergic pathways https://www.biorxiv.org/content/10.64898/2026.06.23.734005v1

Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure https://www.biorxiv.org/content/10.64898/2026.06.23.732949v1

Effect of joint velocity and pre-activation on the torque-fascicle length relationship of the vastus lateralis https://www.biorxiv.org/content/10.64898/2026.06.23.734014v1

Glomerular Hyperfiltration, Charge Selectivity, and the Low-Dimensional Structure of Glomerular Transport https://www.biorxiv.org/content/10.64898/2026.06.23.733946v1

OxyBLI: A Genetics-Based Approach for In Vivo Real-Time Visualization of Tissue Oxygenation Dynamics https://www.biorxiv.org/content/10.64898/2026.06.24.734154v1

Food reward in Bottlenose Dolphins (Tursiops truncatus) and Belugas Whales (Delphinapterus leucas) reduces heart rate and increase heart rate variability. https://www.biorxiv.org/content/10.64898/2026.06.22.733846v1

Identification and characterization of iPTH and two parathyroid hormone receptors-like (PTHR1 and PTHR2) in the tick Ixodes ricinus https://www.biorxiv.org/content/10.64898/2026.06.22.733765v1

Chromatin topology control by a muscle-specific ribosomal protein https://www.biorxiv.org/content/10.64898/2026.06.23.733628v1

Carotid body mitochondria exhibit normal oxygen affinity despite COX4I2 enrichment https://www.biorxiv.org/content/10.64898/2026.06.26.734739v1

Contrasting patterns of lifetime fat metabolism in the vinegar fly, Drosophila melanogaster, and the parasitoid amber wasp, Leptopilina heterotoma https://www.biorxiv.org/content/10.64898/2026.06.24.733671v1

Leucine Aminopeptidase 3 Regulates Skeletal Muscle Mitochondrial Homeostasis with Sex-Dependent Metabolic Consequences https://www.biorxiv.org/content/10.64898/2026.06.20.733486v1

Adipocyte Pten Inhibition Improves Metabolic Health Associated with Expanded Lipid Storage Capacity and Reduced Inflammation https://www.biorxiv.org/content/10.64898/2026.06.20.733549v1

Understanding the biomechanical and physiological responses to Advanced Footwear Technology in well-trained male and female runners https://www.biorxiv.org/content/10.64898/2026.06.19.732297v1

Older adults amplify passive gait stability during obstacle crossing without weakening the stabilizing synergy https://www.biorxiv.org/content/10.64898/2026.06.22.733751v1

Ocean acidification changes diet effects and differentially impacts two populations of red abalone (Haliotis rufescens) https://www.biorxiv.org/content/10.64898/2026.06.18.733263v1

p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging Heart https://www.biorxiv.org/content/10.64898/2026.06.18.733182v1

Exercise training improves exercise capacity independent of AMPKa2 T172-mediated adaptations in skeletal muscle https://www.biorxiv.org/content/10.64898/2026.06.18.733224v1

Severely lipoatrophic mice are hypermetabolic and hyperthermic under thermoneutral conditions in part due to an enhanced liver de novo lipogenesis https://www.biorxiv.org/content/10.64898/2026.06.18.733153v1

Obesity-induced changes in ultrastructure and calcium release of female rat cardiomyocytes are partially reversed by aerobic exercise https://www.biorxiv.org/content/10.64898/2026.06.18.732821v1

The Metabolic Scope Theory of Aging: Rising Mitochondrial Impedance Compresses Metabolic Reserve to Constrain Lifespan https://www.biorxiv.org/content/10.64898/2026.06.18.730063v1

Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response https://www.biorxiv.org/content/10.64898/2026.06.18.732872v1

Developmental programming of adrenal chromaffin cell connexin plasticity by neonatal maternal separation https://www.biorxiv.org/content/10.64898/2026.06.16.732707v1