#Reseach by Hannes Ott from @uniheidelberg.bsky.social and colleagues identified that sodium thiosulfate treatment rescues hyperglycaemia-induced #pronephros damage in zebrafish by upregulating #nitricoxide signalling 🔬 ↔️ Read the study📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Latest issue now live🎉 This special issue '#Endothelial physiology in metabolic diseases: from cells to patients' was organised and edited by Prof. Luis Sobrevia 📖 Read all articles👇️ physoc.onlinelibrary.wiley.com/toc/14697793...

In this #TopicalReview, Paola Valero and colleagues discuss the shortcomings, limitations and gaps in knowledge, providing a framework for enhancing our understanding of the physiological effects of #EVs on #obesity 🔎 🔬 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Abderrezak Bouchama offers this latest response in the wider discussion on 'Redefining human heat limits: integrating molecular and evolutionary physiology' 🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 Call for Papers 📣 Examining preterm birth physiology and pathophysiology across maternal, placental and metabolic contexts 🔍️ 📖 Organised and edited by Prof. Ramkumar Menon & Prof. Luis Sobrevia 🔗 physoc.onlinelibrary.wiley.com/hub/journal/...

'Considering a renal origin of endocrine hypertension in ASIC1a-deficient mice' Yanyu Zhang writes this Letter to the Editor examining the work of García et al. (2026) 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'The balance N1: a double-edged sword?' Helen J. Huang from @ucf.bsky.social offers this #Perspective on the recent work of Jansen et al. (2026) 💭 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this recent study, María de Lourdes Martínez-Silva from @universityofri.bsky.social and colleagues present #machine-learning classification of #motor unit types in the adult mouse 💻️ 🧠 Read the #Research 👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Cameron Hill and co-authors from @kingscollegelondon.bsky.social identified distinct distributions of #myosin motor conformations during contraction of slow and fast skeletal #muscle ⚙️ 🔬 📜 Read the study: 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Advancing the application of allostatic load: athletes, diet and early detection' Imogen Tanner and Liam Corr examine the work of Joubert et al. (2026) in this recent #JournalClub article 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Helena R. Peixoto and colleagues observed that Angiotensin-converting #enzyme 2 enhances megalin-mediated albumin #endocytosis in proximal tubule cells by restraining Angiotensin II/AT1R 🔬 🔎 Read the study 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this recent study, Alyssa M Lyon from @fralinbiomed.bsky.social and colleagues found that steady-state #Purkinje cell activity has limited predictive power for #cerebellar output in disease 🧠 🔎 Read the research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'The lactate (pa)redox of memory' Anja G. Teschemacher from @bristoluni.bsky.social offers this #Perspective on the recent work of Fiumelli et al. ✍️ Read it here 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Xiang-Qun Hu and colleagues found that #microRNA-210-mediated mitochondrial reactive oxygen species contribute to CaV1.2 channel #hyperactivity in uterine arteries of pregnant sheep acclimatized to high-altitude hypoxia 🔬 🔎 Read the research👇️ 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Nikki L. Jernigan from @unm.edu responds to the Letter to the Editor from Yanyu Zhang: ‘Considering a renal origin of endocrine hypertension in ASIC1a-deficient mice’ ✍️ ✉️ Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

A high-fat, high-sugar diet impairs maternal #metabolism throughout #pregnancy and lactation in mice 🍽️ 🔎 📜 Read the latest findings from Stephanie E. O'Hara and colleagues 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Clément Lanfranchi and colleagues at @unil.bsky.social observed that oleuropein-based olive leaf extract enhances #muscle mitochondrial #bioenergetics response to moderate – but not maximal – intensity #exercise in humans 💊 🚴 Read the study here👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this Letter to the Editor, Philémon Marcel-Millet and colleagues respond to the opinion paper by Bouchama (2025) entitled ‘Redefining human heat limits: integrating molecular and evolutionary physiology’ ✉️ ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Redox balance and metabolic flexibility in fast-twitch oxidative–glycolytic muscle fibres: rethinking aerobic lactate production' McKinley A. Kennedy @utoronto.ca and co-authors discuss the work of Disch et al. (2026) in this recent #JournalClub ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Seeing is believing: metabolic sensors illuminate cell‑specific metabolic requirements' Nuno Valente-Leal and Zita Carvalho-Santos from @gimminstitute.bsky.social offer this #Perspective on the recent work of Müller et al. ✍️ 💭 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this review, Mohammad-Reza Ghovanloo & Stephen G. Waxman from @yaleschoolofmed.bsky.social provide a framework for understanding the nuanced role of #Nav channels in health and disease ✍️ Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Hubert Fiumelli and colleagues reveal a #molecular pathway by which #lactate, produced by astrocytes, can significantly influence neuronal activity and synaptic function, linking brain metabolism with learning and memory processes 🧠 ⚙️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Research from Stephan Müller and colleagues at @tudresden.bsky.social observed that #neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to #NADPH reduction and elevated oxidative stress 🔬 🧠 Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Light-based pain killer: Transcranial photobiomodulation for pain suppression' Suyash Mehta and Cushla McGoverin examine the work of Wang et al. (2026) in this recent #JournalClub article ✍️ 🔗 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Thomas H. Topham and colleagues investigated the influence of age and biological sex on #sweating in children exercising in warm and hot environments with comparison to adults 🌡️ 🏃‍➡️ Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Melanocortin 4 receptor signalling in sleep-disordered breathing' Md Tarikul Islam and colleagues review the MC4R pathway in respiratory control🛌 🧠 Read it here 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'What homeostasis leaves out: Kinorhesis, a physiological principle of transformation' 💭 ✍️ Read this recent #Opinion article from Nelson D. Horseman 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Takuya Kurazumi and colleagues present a cascade model of dynamic cerebral #autoregulation in this recent study 🫀 ➡️ Read the #research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jansen et al. from @erasmusmc.bsky.social studied brain activity in maintaining standing balance during perturbations, finding that characteristic cortical electric activity represents the brain's detection and evaluation of unexpected sensory events. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Latest issue now live! The cover art symbolises the work of Jansen et al., who observed that cortical responses to balance perturbations persist without active postural control🧠 📖 Read the full issue 👇️ physoc.onlinelibrary.wiley.com/toc/14697793...

Call for Papers📣 Highlighting converging mechanisms through which microvascular dysfunction contributes to metabolic disease, neurodegeneration, endocrine imbalance and inflammation driven vascular pathology🧠 For full information and how to submit👇️ physoc.onlinelibrary.wiley.com/hub/journal/...

Grith Højfeldt, Paul T. Morgan and Casper Soendenbroe examine the new U.S. dietary guidelines and offer the #Opinion that increasing protein intake without increased physical activity is unlikely to improve muscle health 💭 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Recent #Research by Javier Yanguas Mayo from @i3a.unizar.es and colleagues concludes that spinal motor #neuron pools may be partly driven by impulsive common inputs 🧠 🔎 Read the study 👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this recent study, S. Fang and colleagues investigated #neurophysiological sensitivity to envelope and pulse timing interaural time differences in #cochlear implanted rats with different hearing experiences 🧠 👂️ 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Kim Barrett and Damian Bailey reflect on the importance of recognising excellent in peer review and celebrate the newly launched 'Exceptional Referees' initiative at the journals 🎓️ 🎉 🔗 Read the Editorial: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Lingyun (Ivy) Xiong @keck.usc.edu & Alan Garfinkel @domucla.bsky.social take a #systems approach to argue that oscillations play critical physiological roles 📣 🧪 🔗 Read their review physoc.onlinelibrary.wiley.com/doi/10.1113/...

Bruce P. Bean of @harvardmed.bsky.social offers this reply to a recent letter presenting an alternative mechanism for slow pacemaking ✍️ ✉️ 🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

A new @jphysiol.bsky.social publication found neonatal hypertensive rats had hypoventilation, apnoeas and oxygen desaturation. #OxyLite directly monitored brain pO₂, showing breathing irregularities were linked to local brain hypoxia during a critical developmental window. #Hypoxia #Hypertension

Susan Wray @liverpooluni.bsky.social and Michael J. Taggart @newcastleuni.bsky.social provide an update on #pacemaking in the #myometrium ✍️ ⏰️ 📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Vincent Seutin, Kevin Jehasse and Guillaume Drion from @universitedeliege.bsky.social present an alternative mechanism for slow pacemaking in this #LettertotheEditor ✉️ ✍️ Available here 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Hikaru Hashitani @en.nagoya-u.ac.jp, Mitsue Takeya & Dirk F. van Helden @newybrains.bsky.social discuss commonality and heterogeneity of #pacemaker mechanisms in the male reproductive organs✍️ 🔬 Read the #TopicalReview: 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this #TopicalReview, Nathan Grainger of @unevadareno.bsky.social discusses the role of resident #pacemaker cells in the #renal pelvis and argues that a greater understanding of pacemaker and peristaltic mechanisms is warranted 🔬 🔎 Read it here: 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Bernard T. Drumm, Neha Gupta, Alexandru Mircea & Caoimhin S. Griffin examine the cells and ionic conductances contributing to spontaneous activity in #bladder and #urethral smooth muscle 🔬 🔄 Read the review 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this review, Kenton M. Sanders of @unevadareno.bsky.social, L. Fernando Santana of @ucd-physiology.bsky.social & Salah A. Baker summarise key mechanisms responsible for electrical rhythmicity in gastrointestinal organs ⚡️ 🔎 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

David I. Yule & Takahiro Takano from @urochester.bsky.social propose a model for ‘pacing’ #intracellular Ca2+ signals in acinar cells 🔬 🔎 📜 Read the review: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this review, Bruce P. Bean of @harvardmed.bsky.social examines the mechanisms of #pacemaking in mammalian #neurons, highlighting that few spontaneously active neurons rely on #HCN ‘pacemaker’ channels for their activity 🧠 ⚙️ 📜 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓️ Editor's Choice 🎓️ In an excellent review of an often-overlooked area, Davis and Zawieja make the case for the #myogenic origin of #pacemaking that supports #lymphatic pumping and tissue fluid homeostasis 🔎 📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Eilidh A. MacDonald uofglasgow.bsky.social & T. Alexander Quinn @dalhousie.bsky.social provide a basic overview of the mechanisms responsible for cardiac automaticity & discuss factors critical for integrated cardiac #pacemaker function 🫀 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In the latest 'Voices of Physiology' blog, Dr Joe Welch from @unibirmingham.bsky.social, an Editorial Board Fellow for The Journal of Physiology, explains his research background and how he came to be involved with PhySoc #150Voices 🎓️ 📣 Check it out👇️ 🔗 www.physoc.org/blog/dr-joe-...

'Making a case, for who is setting the pace: conductors, drummers or just jamming in #multicellular organ systems?' In this opening Editorial, Bernard T. Drumm & T. Alexander Quinn introduce the articles included in the special issue ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...