This study by Alec L. E. Butenas of kstate.bsky.social et al. observes that #protein kinase C epsilon contributes to chronic #mechanoreflex sensitization in rats with heart failure 🫀 🧠 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Yu Huo of utexasglobal.bsky.social et al. observed that interleukin-1 type 1 receptor blockade attenuates the exaggerated #exercise pressor reflex in male UC Davis type 2 #diabetic mellitus rats 🧠🫀 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/full/10....

❗Now extended to 1st December 2025⏰

This #Perspective by Alec L. E. Butenas examines muscle acidosis in the exercise pressor reflex based on the study by Ducrocq et al. (2025) ✍️ 🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

📣 Call for Papers📣 ⏰ Deadline: 1st October 2025 ⏰ For the special issue "Experimental and quantitative modelling approaches in cardiac and vascular physiology: focus on ion channels and Ca2+ regulation" 🔗 For more information & how to submit: physoc.onlinelibrary.wiley.com/hub/journal/...

Guillaume P. Ducrocq et al. observed that lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during #ischaemic contractions but not during freely perfused contractions 🔬 🏃 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Jamie P. Kaluhiokalani et al. finds that 6 weeks of localized passive #heat therapy elicits some exercise-like improvements in resistance #artery function 🔬 ♨️ 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/full/10....

Sean P. Langan presents this #JournalClub on the work of Garcia-Retortillo and Ch Ivanov (2025) examining complex (a)synchrony of heart–muscle interactions during exercise ✍️ 🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Juan A. Estrada et al. observed that intracerebroventricular #insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 #diabetes mellitus 💉 🧠 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/full/10....

In this opening #Editorial, Senior Editor Vaughan G. Macefield introduces the special issue 'Regulation of cardiovascular and skeletal muscle function during exercise' 📖 📝 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study, Sarah E. Alexander of deakinuniversity.bsky.social et al. find that bioavailable #testosterone and androgen receptor activation, but not total testosterone, are associated with #muscle mass and strength in females 🏃‍♀️ 💪 📜https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP286803

#Research by Kavya Phadke et al. examines atrial #cardiomyopathy resulting from loss of plakophilin-2 expression🫀 🔎 📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this recent #SymposiumReview, Hye Jin Kim et al. examine mouse models for #metabolic health research, focusing on the molecular mechanism of exercise effects on health improvement through #adipose tissue remodelling 📖 🔎 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Ayako Takeuchi & Satoshi Matsuoka performed a simulation study on the role of #mitochondria-sarcoplasmic reticulum Ca2+ interaction in #cardiomyocyte energetics during exercise 🏃 🔬 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Delighted to announce that my first postdoc work with @bathellierlab.bsky.social got on offset responses in the auditory system got published in the Journal of Physiology! tinyurl.com/3amwj39w

🎓 EDITOR'S CHOICE🎓 Emi Narai et al. present a novel, rapid role of the #orexinergic nervous system as a crucial substrate in the brain circuit mechanisms that coordinate somatomotor & autonomic #cardiovascular controls for locomotor exercise. 📜🔗 physoc.onlinelibrary.wiley.com/doi/full/10....

A Journal Club by Rodrigues and Sobrinho on our recent paper "Evidence for control of cerebral neurovascular function by circulating platelets in healthy older adults" in @jphysiol.bsky.social physoc.onlinelibrary.wiley.com/doi/full/10....

2 min video of our recent study in J Physiol. physoc.onlinelibrary.wiley.com/doi/10.1113/... The link below:

Our latest issue titled "Regulation of cardiovascular and skeletal muscle function during exercise" is now live! 🫀 🏃 📖 🔗 physoc.onlinelibrary.wiley.com/toc/14697793... This special issue was organised and edited by Professors Vaughan Macefield, Yoshihiro Kubo and Marc Kaufman.

Check out this #PhysiologyShort where Prof. @juhahulmi.bsky.social talks through his research finding that human skeletal muscle possesses both reversible #proteomic signatures and a retained proteomic memory after repeated #resistance training 🏃 🧬 📽️🔗 www.youtube.com/watch?v=r2Bq...

This #Reply by Matthew N. Rasband et al. expands on their conclusions that loss-of-function β4 spectrin variants cause a myopathy that is neurogenic in origin ✉️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Sophia G. Gibbons & Rob J. MacLennan examine applications of high-density EMG and motor unit analysis for understanding pain-induced inhibition and the work of Hug et al. (2025)✍️ Access the #JournalClub here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Arijit Roy et al. found that diet-induced #obesity in mice increases #carotid body chemosensitivity via the leptin-TRPM7 pathway 🫀🫁 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this #LetterToTheEditor, Jonathan De Winter et al. offer that loss-of-function variants in SPTAN1 and SPTBN4 cause early-onset hereditary #myopathy ✉️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Shivam Malviya offers this #JournalClub article examining impaired ion clearance as a key driver of #pathology in diseases, based on the work of Samokhina et al. (2025) ✍️ Access it here: 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this recent study, Ashley S. Meakin et al. investigate sex-specific effects of #betamethasone on glucocorticoid and apoptotic signalling pathways in the sheep #placenta 🧬 ♀️ 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Clare M. Reynolds of ucddublin.bsky.social offers this #Perspective on cardiovascular trade-offs of metformin use in pregnancy based on research by Schoonejans et al. (2025)✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Dillon C. Malloy et al. observed that transcutaneous #spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat 🧠 ⚡ 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

M. Hernández Mesa et al. observed that #spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks ⚙️ 📍 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Caitlin R. Ritchey et al. finds that characterization of NTS-to-VTA projection neurons reveals higher-order #synaptic organization and distinct responsiveness to #cholecystokinin 🧠 💉 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

This study by Maria Vittoria Leonardi et al. highlights that Piezo1 is an essential player in volume regulation of human #glioblastoma cells 🔎 ⚡ 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Nathan Serrano et al. present this #Opinion piece providing a critical evaluation of muscle memory theory 💭 💪 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Tzu-Yi Lee et al. observed that 5-HT7 antagonists confer analgesia via suppression of #neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity 🔬 🔃 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Gabriela Geraldo Benzoni offers this #JournalClub article discussing time-restricted feeding and autophagic flux based on the recent work of Bensalem et al. (2025) ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓 EDITOR'S CHOICE 🎓 Schoonejans and colleagues now show that when female mice are given metformin in addition to an obesogenic diet during #pregnancy, their offspring display various adverse impacts on #cardiovascular health in a sex-specific manner. 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jeremy K. Alpenglow & Jarred J. Iacovelli of @utah.edu discuss the work of Wakeham et al. (2025) in this #JournalClub 'NPY joins the club of vasoconstriction pathways that get no sympathy during exercise' ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

A recent #JournalClub by Thomas Hobbs examines how #diabetes and exercise remodel the myonuclear transcriptome in a fibre type-dependent manner, based on Hansen et al. (2025) ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The latest issue is live! Featuring cover art by Schoonejans et al. depicting thoracic aortic thickness in a 12-month-old female mouse exposed to maternal glucose intolerance and metformin treatment in utero. 📖 Read the full issue here: physoc.onlinelibrary.wiley.com/toc/14697793...

In this #LetterToTheEditor Elapulli Sankaranarayanan Prakash questions 'Do brainstem astrocytes function as cerebral perfusion pressure sensors, as cerebral perfusion sensors or as sensors of specific consequences of cerebral hypoperfusion?' ✉️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

🌟 We made the cover🌟 Our image of a female aorta exposed to #metformin in utero is on the cover of @jphysiol.bsky.social. The paper was also the Editor's Choice! Interested? I'm presenting this next Wednesday at #DOHAD2025 in Buenos Aires (PS3.002). Come say hi or connect on here! #DOHaD

In this #JournalClub Kallie E. Dawkins et al. examine dopaminergic modulation of oxygen-sensing organs during hypoxia and the work of Reed and Jonz (2025) ✍️ 🔗 Available here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Joseph J. Smolich observed that non-ventilatory events substantially contribute to rise in #pulmonary arterial blood flow with early or delayed cord clamping at birth in preterm lambs 🫁 💉 📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

M. V. Franchi et al. offer this #TranslationalPerspective highlighting new insights into acute tendon molecular reprogramming after rupture based on research by Mimpen et al. (2025)✍️ 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this #Research article, Borong He of cuhk-gcni.bsky.social et al. examine state-dependent #neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation 🔬 🔎 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Mohini Sengupta discusses the development of spinal Shox2 neurons and the work of Singh et al. (2025) ✍️ 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

🚨 What's the interplay between sleep and mitochondrial dynamics in neurons? I am happy to share this invited review I wrote for The Journal of Physiology @jphysiol.bsky.social 👉 physoc.onlinelibrary.wiley.com/doi/full/10.... 🧵 Thread 👇 #Neuroscience #SleepResearch

Recent #Research by Mitsuhiro Nito et al. observes that transcutaneous spinal random noise stimulation enhances motor memory consolidation and corticospinal transmission in humans 🧠 ⚙️ 📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Ingvars Birznieks of unsw.edu.au examines C-tactile afferents and the recent study by Moore et al. (2025) in this #Perspective article ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

This #TopicalReview by Katia S. G. Andrade et al. examines targeting #ALDH2 to promote skeletal muscle health as a novel strategy against #mitochondrial dysfunction 💉 🔎 🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this joint #Perspective, Dongun Lee and Shmuel Muallem discuss the exocrine pancreas and NAADP in relation to research by Takano et al. (2025) ✍️ 🔗 Access the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...