I'm so excited to have been part of this very fun project in collaboration with the Zhang lab! 💻💙 Please check out our preprint on this beautiful channel-like protein called XPR1 here at www.biorxiv.org/content/10.1...

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵 💻 by @ciarawallis.bsky.social & @riottowow.bsky.social

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

Commentary from @willppk.bsky.social on a new study by @elainetao.bsky.social and @corrylab.bsky.social (https://buff.ly/4gXybTY) that uses an enhanced sampling method, metadynamics, to identify and classify Naᵥ channel blockers. https://buff.ly/4fJq8ck #IonChannels

New: @elainetao.bsky.social and @corrylab.bsky.social‬ investigate the binding of sodium channel inhibitors to the Naᵥ1.5 pore using simulations, revealing promiscuous, polyspecific binding at the fenestrations and central cavity. https://buff.ly/40rLqHb

Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70