Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature Sorry it is paywalled…. But look at the beautiful channels 🥲 www.nature.com/articles/s41...

Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure physoc.onlinelibrary.wiley.com/doi/10.1113/...

Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...

Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access. www.tandfonline.com/doi/full/10....

Mouse retinal ganglion cells and night blindness | TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells J.General Physiol. rupress.org/jgp/article/...

Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology Paywalled bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications www.nature.com/articles/s41...

Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...

Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience www.nature.com/articles/s41...

Curious… what’s up? #IonChannels Expression of Concern www.tandfonline.com/doi/full/10....

Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology. rupress.org/jgp/article/...

Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$¥ rupress.org/jgp/article/... TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications www.nature.com/articles/s41...

Delta-type glutamate receptors are ligand-gated #ionchannels |Nature £$¥€ www.nature.com/articles/s41...

TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures www.frontiersin.org/journals/pha... #IonChannels

Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports www.nature.com/articles/s41...

Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications www.nature.com/articles/s41...

A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42... Open access

TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Twisting the Gate: How PIP2 Powers Kir #IonChannels MD simulations reveal how PIP2 binding triggers conformational shifts that open Kir2, twisting cytoplasmic domains, reshaping gates, and enabling ion flow. $$$ rupress.org/jgp/article/...

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814...

Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/...

Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic academic.oup.com/brain/advanc...

The molecular transition that confers voltage dependence to muscle contraction | Nature Communications www.nature.com/articles/s41... #ionchannels

The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable #ionchannel (never heard of it before) - Nature Communications www.nature.com/articles/s41...

Identification of druggable binding sites and small molecules as modulators of TMC1 | Communications Biology www.nature.com/articles/s42... #ionchannels

A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ #ionchannel KtrAB | Nature Communications www.nature.com/articles/s41...

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature #ionchannels www.nature.com/articles/s41...

Nicotinic acetylcholine receptor #ionchannels regulate growth hormone in pituitary somatotrophs …in tigers… www.nature.com/articles/s42...

Commentary: Lawrence Salkoff @washumedicine.bsky.social discusses new studies of potassium channel #evolution from the Jegla group (rupress.org/jgp/article/...) that contributes valuable insights into the evolution of complexity in electrical signaling. rupress.org/jgp/article/... #IonChannels

Patch clamp #ionchannel assay for NaV1.5-Brugada Syndrome. #SCN5A

Such a good feeling to get data again #patchclamp

Preferential allosteric modulation of Otop1 channels by small molecule compounds | Communications Biology #ionchannels www.nature.com/articles/s42...

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications #ionchannels www.nature.com/articles/s41...

Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation | Cell Death & Disease #ionchannels www.nature.com/articles/s41...

Ball-and-chain inactivation of a human large conductance calcium-activated potassium #ionchannels www.nature.com/articles/s41...

Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannels www.nature.com/articles/s42...

HCN4 channels sense temperature and determine heart rate responses to heat | Nature Communications #ionchannels www.nature.com/articles/s41...

Venom-derived toxins offer unique precision in ion channel research. We tested Huwentoxin-IV, TTX, GsMTx4 & α-Conotoxin MI on NaV1.7 and nAChR to explore their blocking effects. Want to learn more? Read more in the full study: ow.ly/bKoG50Vgpy3 #IonChannels #DrugDiscovery #APC

Oops #ionchannels

Maturational Stage Dependent Contributions of the Cav3.2 T-type Calcium Channel to Dentate Gyrus Granule Cell Excitability - PubMed

European Calcium Channel Conference 2025 Early registration and abstract submission are still open until March 10, 2025! For additional information, please visit the meeting website: calciumchannel.eu and for registration: calciumchannel.eu/registration... #calcium #channelopathies #ionchannels

In a pioneering study, Achouba et al. successfully integrated photoswitch technology into a complex, disulfide-rich peptide ChTx while retaining high nanomolar potency for ion channels. Read more here: www.nanion.de/news/optical... #ionchannels #optogenetics #patchclamp #APC #venom #toxins

Proud moment as a supervisor when my medicine honours student from last year received the "Student Researcher of the Year Award" from the UNSW St Vincent’s Clinical School. Jess established our SCN2A #ionchannel patch clamp assay to study variants of uncertain significance detected in Australia.

Breakthrough Discovery Reveals How Key Ion Channel Regulates Itself #Science #Biology #CellBiology #IonChannels #CellRegulation #BiologicalDiscovery

By molecular dynamics simulations and in silico electrophysiology, Alp Tegin Şahin and Ulrich Zachariae show how the #lipid PIP2 opens the human TPC2 #IonChannel and that its ion selectivity is established by an interplay of key structural elements of the pore. https://buff.ly/4gPpxq1