𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗼𝗽𝗲𝗻 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁! Get 9 months with the system, consumables, and full support to accelerate your research. Deadline: Oct 31. Apply now! ow.ly/9gx050X0OOW #APC #IonChannels #Electrophysiology

Reduce variability in NaV studies with adaptive voltage clamp on the SyncroPatch 384. Tailor Vhalf per well, gain better IC50 precision, and study state-dependent effects with confidence. Check out the flyer to see how it works! ow.ly/8QMU50WFXei #APC #IonChannels #NaV #Electrophysiology

How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome? Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes. 📍https://ow.ly/PxZY50W72H7 #PatchClamp #Channelopathies #IonChannels

In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format. Read more here: www.nanion.de/news/automat...

Most cardiac gene variants are still classed as “uncertain.” Join us on Thursday to learn how APC is helping reclassify VUS and improve clinical decisions. 🗓️ May 8 | 16:00–17:00 CEST 🔗 ow.ly/RQfB50VFl93 Hope to see you there! #CardiacGenetics #APC #VUS #LQTS #Brugada

How do beta-lactam antibiotics get into our cells, and how can we use that to design better drugs? Join our webinar on May 14 to explore new insights into PepT2, drug uptake, and delivery. 🔗 Register: ow.ly/1mCL50Vo2j8 #PepT2 #DrugDesign #CryoEM #Webinar

Why is NHE9 active in endosomes but silent at the membrane? A new Nature Communications study reveals a lipid switch: PI(3,5)P₂ stabilizes NHE9’s dimer only in endosomes. 🔗Read the full article to find out more: ow.ly/zrsR50VAAZW #MembraneTransport #CryoEM #SSME

Join us in exactly one month for our next transporters webinar! Dr. Joanne Parker (University of Oxford) will present research insights on PepT2 (SLC15A2), a key player in beta-lactam antibiotic transport. 📅 May 14, 2025 | 🕓 16:00–17:00 CEST 🔗 Register here: ow.ly/1mCL50Vo2j8 #MembraneTransport

𝗖𝗮𝗻 𝘄𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘁𝗵𝗲 𝘄𝗮𝘆 𝘄𝗲 𝗶𝗻𝘁𝗲𝗿𝗽𝗿𝗲𝘁 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗴𝗲𝗻𝗲 𝘃𝗮𝗿𝗶𝗮𝗻𝘁𝘀? Join Dr. Chai Ng (Victor Chang Cardiac Research Institute) on May 8 to explore APC’s role in variant classification for inherited arrhythmias. 🔗 ow.ly/XrnO50VymFI #Webinar @chaiannng.bsky.social @victorchang.edu.au

iPSC-CMs are powerful, but their immaturity limits their predictive value. A recent study from TU Dresden shows how combining metabolic medium, nanopatterning, and electrostimulation significantly enhances structural and electrophysiological maturation. 🔗 lnkd.in/dipXpmyN #Cardiac #iPSC #APC

TRPV3 is a temperature-sensitive, ligand-gated ion channel known for its role in warmth perception. It can be activated by heat (~ 38˚C) or by 2-APB, and we have explored both activation modes using APC with temp control. Read the app note: ow.ly/YMp850R6hwG #TRPV3 #IonChannels #Electrophysiology

Cryo-EM reveals how cholesterol and sphingomyelin shape the structure and stability of a membrane pore formed by the toxin Fav. Electrophysiology with the Orbit Mini confirms cholesterol reduces current noise. 🔗 Read more in the paper: ow.ly/sPmJ50VusCf #CryoEM #MembraneBiophysics #Orbitmini

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗲𝘁𝗮-𝗹𝗮𝗰𝘁𝗮𝗺 𝗮𝗻𝘁𝗶𝗯𝗶𝗼𝘁𝗶𝗰𝘀 𝗲𝗻𝘁𝗲𝗿 𝘁𝗵𝗲 𝗯𝗼𝗱𝘆? And why does it matter for drug design? Join us on May 14 as Joanne Parker (University of Oxford) presents new insights into the structure and function of PepT2, a key transporter in beta-lactam pharmacokinetics. ow.ly/1mCL50Vo2j8 #MembraneTransport

Understanding cardiac function needs more than one readout This flyer shows how combining electrophysiology, contractility & viability data offers deeper insights into drug effects & disease models. Discover more in the flyer: ow.ly/LGRs50VnV0o #CardiacResearch #iPSC

Studying pore-forming toxins? At Nanion, we provide advanced tools - parallel bilayer recording stations, GUVs, and planar patch clamp systems - to help researchers get a clearer picture of how these toxins work. Learn more: www.linkedin.com/feed/update/... #PFT #toxins #electrophysiology

Working with toxins & ion channels? Testing multiple fractions and screening channels with limited samples is tough. That’s why more scientists are turning to automated patch clamp for faster, reliable results. Curious? Learn more: www.nanion.de/application-... #ionchannels #toxins #patchclamp

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺! From ion channels to drug discovery—discover what’s next in electrophysiology. Connect with leading experts in Napa Valley! 📅 Apr 30–May 1 𝗟𝗶𝗺𝗶𝘁𝗲𝗱-𝗧𝗶𝗺𝗲 𝗢𝗳𝗳𝗲𝗿: 𝟭𝟱% 𝗢𝗳𝗳 𝗧𝗶𝗰𝗸𝗲𝘁𝘀 Register now 🔗 ow.ly/SmfE50VgoHz #MPS25 #MembranePhysiology

Venom-derived toxins offer unique precision in ion channel research. We tested Huwentoxin-IV, TTX, GsMTx4 & α-Conotoxin MI on NaV1.7 and nAChR to explore their blocking effects. Want to learn more? Read more in the full study: ow.ly/bKoG50Vgpy3 #IonChannels #DrugDiscovery #APC

In a pioneering study, Achouba et al. successfully integrated photoswitch technology into a complex, disulfide-rich peptide ChTx while retaining high nanomolar potency for ion channels. Read more here: www.nanion.de/news/optical... #ionchannels #optogenetics #patchclamp #APC #venom #toxins

𝗛𝗲𝗮𝗱𝗶𝗻𝗴 𝘁𝗼 𝗡𝗲𝘅𝘁𝗚𝗲𝗻 𝗕𝗶𝗼𝗺𝗲𝗱 𝟮𝟬𝟮𝟱? 𝗟𝗲𝘁’𝘀 𝗖𝗼𝗻𝗻𝗲𝗰𝘁! Meet us at Booth #60 to see AtlaZ in action—now GxP compliant! Get real-time, label-free insights into cell activity & viability and explore its impact on drug discovery & immuno-oncology. 🔗 ow.ly/nl0s50Vafhh #NextGenBiomed #GxP #AtlaZ

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗦𝗮𝗳𝗲𝘁𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝟮𝟬𝟮𝟱! 📅 May 21, 2025 | 🌍 Virtual The symposium will bring together experts to discuss the latest advancements in safety pharmacology, cardiac physiology, and electrophysiology. 🔗 Learn more and register here 👉 ow.ly/VvWl50TPkbR #CardiacSafety #Pharmacology

AtlaZ now offers 𝗙𝗗𝗔 𝟮𝟭 𝗖𝗙𝗥 𝗣𝗮𝗿𝘁 𝟭𝟭 𝗰𝗼𝗺𝗽𝗹𝗶𝗮𝗻𝗰𝗲, ensuring secure, traceable, and audit-ready data for regulated research. ✅ Secure access & user tracking ✅ Audit trails & data integrity ✅ Compliance made simple 📄 Learn more: ow.ly/Oaln50V6Qk3 #CellAnalytics #GxPCompliance #21CFRPart11

Our latest case study highlights how Frédéric Becq from the University of Poitiers uses automated patch-clamp technology to deepen our understanding of CFTR function and its interactions with drugs. Read more here: www.nanion.de/wp-content/u... #ionchannels #CFTR

𝗛𝗼𝘄 𝗰𝗵𝗮𝗻𝗻𝗲𝗹𝗼𝗽𝗮𝘁𝗵𝗶𝗲𝘀 𝗮𝗿𝗲 𝗮𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆? 🧬 Mutations in ion channels are linked to 1,300+ genetic disorders, many driving rare diseases. Understanding these mutations enables faster, more precise profiling, crucial for targeted therapies. 🔗 ow.ly/C0ST50V60SB #RareDiseases #DrugDiscovery

The INNOVATION consortium is shaping the next generation of researchers! At our recent meeting, students gained hands-on training while project leaders planned the next steps. Exciting progress in RBC ion channel research. Looking forward to future breakthroughs! 🚀 #IonChannels #Electrophysiology

Silent Molecular Translocation Some molecules move through nanopores without altering ionic currents, remaining invisible to traditional methods. The Orbit mini captures these silent events using optical + electrical recordings, unlocking new insights in biophysics & diagnostics ow.ly/HLFM50V16oS

A recent study provides detailed structural insights into how potassium-selective channelrhodopsins (KCRs) function. Read here: www.nanion.de/news/light-g... #ionchannels #optogenetics #patchclamp #APC

The Biophysical Society Meeting, starts today! Check out our activities: 🔹 Ion channel drug discovery at our Satellite Meeting - Today! 🔹 Booth #509 – Live demos & latest innovations 🔹 Feb 17, 11:30 AM – Join us at our Exhibitor presentation 🔹 Don´t miss out on our Posters lnkd.in/dPKd-Q2B #BPS25

Join us at the Membrane Physiology Symposium 2025! 📅 April 30 – May 1, 2025 📍 Napa Valley, CA Two days of cutting-edge science, expert talks, and networking in a stunning location. Connect with top researchers and industry leaders. 🔗 Register now: lnkd.in/dW23dG-t #MPS25 #MembranePhysiology

A recent study from @lampertlab.bsky.social demonstrates that phentolamine inhibits NaV1.7 and NaV1.5 channels through the local anaesthetic receptor site, a mechanism that may conflict with its intended use as an antidote for local anaesthetic toxicity. www.nanion.de/news/phentol... #ionchannels

Today, on World Cancer Day, we stand with everyone affected by cancer – the patients, the families, the researchers, the doctors, and all those who keep hoping for better days ahead. www.linkedin.com/posts/nanion... #worldcancerday #cancer #ionchannels #transporters

Join us at #BPS2025! We're presenting six posters on ion channels, transporters, GPCRs & electrophysiology at the Biophysical Society Meeting in LA. 📅 Feb 16–18 | 📍 West Exhibit Hall 🔬 Stop by our posters & Booth #509 to chat! ow.ly/SzmM50UR5sP #Biophysics #Electrophysiology #IonChannels

A new study introduces poly(C9) #nanopores, self-assembled from complement component 9, for precise single-protein analysis. poly(C9) nanopores enable highly sensitive and accurate characterization of a wide range of natively folded proteins on a single molecule level. www.nanion.de/news/self-as...

TMEM175 helps regulate pH, membrane potential, and autophagy. Its role in Parkinson’s & Lewy Body Dementia raises key questions for drug discovery. Using SSME, we measure TMEM175’s proton and potassium currents with precision. Learn more: ow.ly/5fhx50TtZRL #SSME #DrugDiscovery #LysosomalChannel

Heading to BPS 2025? Join us in LA! 📍Meet us at booth #509: Live demos + cutting-edge tools for ion channel research. 📢 Exhibitor presentation - Feb 17 @ 11:30 AM, Room 404AB: Deep learning, lysosomal insights & lipid bilayers. 📊 Check out our posters More info here: lnkd.in/dPKd-Q2B #BPS25

Automated patch clamp systems are often used for routine compound testing and validating drug targets. But what if you need to explore the detailed properties of single ion channels? Explore our flyer to learn more about this approach: ow.ly/iMzT50UL79m #IonChannels #SingleChannel #APC

Recent findings reveal a previously unrecognized structural role of the #KCNQ2 pore turret and its involvement in neurodevelopment and epileptogenesis. Read more here: www.nanion.de/news/diverse... #ionchannels #channelopathies

𝗡𝗮𝗻𝗶𝗼𝗻 𝘁𝘂𝗿𝗻𝘀 𝟮𝟯! 🎉 We’re grateful for 23 years of trust, collaboration, and innovation with our team, customers, and partners. Thank you for being part of our journey! 👉 Read our annual review from CEO Niels Fertig: ow.ly/jLkp50UGNAB #TeamNanion #Anniversary

Discover new frontiers in ion channel and transporter research at our upcoming exhibitor presentation at the Biophysical Society Meeting 2025. Learn more here: ow.ly/uJgF50UrEuf 📅 Monday, February 17, 2025 🕚 11:30 AM – 1:00 PM 📍 Room 404AB Looking forward to meet you! #BPS2025 #IonChannels

If you’re passionate about #ionchannels and enjoy exploring the latest in science, Marc Rogers’ blog series on preclinical ion channel drug discovery are a must-read. Read more here: www.linkedin.com/feed/update/... #drugdiscovery #blog

A recent study has uncovered a significant association between rare SCN2A variants and malformation of cortical development in patients with developmental and epileptic encephalopathy. -- Find the full article here: onlinelibrary.wiley.com/doi/full/10.... #ionchannels #channelopathies

Pre-register for "Drug Discovery for Ion Channels XXV" satellite meeting at #BPS2025! Discover innovations reshaping ion channel drug discovery, from high-throughput electrophysiology to modulation strategies. Learn, connect & network! Deadline: Jan 10, 2025. Info: ow.ly/2zF350UaR7Q

𝗔𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀 𝗮𝘀 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗺𝗼𝗱𝘂𝗹𝗮𝘁𝗼𝗿𝘀 Marc Rogers explores monoclonal antibodies, nanobodies, and antibody-toxin chimeras in ion channel drug discovery. Discover key case studies and breakthroughs shaping immunology, neuroscience & oncology. 📖 Read more: ow.ly/1y2f50UtoFs #DrugDiscovery #APC

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝗕𝗣𝗦 𝟮𝟬𝟮𝟱! Explore novel research insights at our exhibitor talk: "Novel Insights into Ion Channel and Transporter Research: From Silent Translocation to Deep Learning Tools" 📅 Feb 17, 2025, 🕚 11:30 AM, 📍 Room 404AB. Visit Booth #509 to connect! Learn more: ow.ly/uJgF50UrEuf #BPS2025

𝗠𝗼𝗻𝗶𝘁𝗼𝗿𝗶𝗻𝗴 𝗦𝗲𝗻𝗲𝘀𝗰𝗲𝗻𝗰𝗲 𝗶𝗻 𝗖𝗮𝗻𝗰𝗲𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵: Nanion & Uni Tübingen explore how cellular senescence halts tumor growth while its inflammatory effects can fuel cancer. Unlock insights in our white paper & redefine oncology strategies. Read now: ow.ly/6PZJ50Un7OV #CancerResearch #Senescence #Oncology

From sensing touch to regulating blood pressure, mechanosensitive ion channels are vital players in mechanotransduction. 𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀: PIEZO (touch/pain), MET (hearing), OSCA (stress), K2P (stretch/temp), NOMPC (invertebrates). Discover more: ow.ly/Qn8K50QMiZV #IonChannels #Mechanosensation #APC

𝗗𝗶𝗱 𝘆𝗼𝘂 𝗺𝗶𝘀𝘀 𝗼𝘂𝗿 𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴? From organelles to tissues, and molecular mechanisms to nanosensing, the meeting explored research insights into the "small things" that are driving groundbreaking discoveries. Watch now: ow.ly/IgMT50UaOy8 #APC #CellAnalytics #MembraneBiophysics