Original: Network analysis by Drs. Devecchi, Falla et al. identified disability as the central driver of cervical radiculopathy, while ~25% of patients showed a complex profile with nociplastic pain features FREE:

Original: Collyer, Dr. Farrell et al. explored if systemic levels of C-reactive protein and vitamin D predicted later chronic musculoskeletal pain —no association was found with later chronic musculoskeletal pain FREE: www.jpain.org/article/S152...

Original: Dr. Webb, Goodin, et al. examined differences in sleep quality, experimental pain sensitivity using quantitative sensory testing (QST), and clinical pain severity by HIV and insomnia status. FREE: www.jpain.org/article/S152...

Original: Drs. Saravanan, Young, et al. recruited patients with axial-chronic low back pain and healthy controls to complete collection of rectal swabs and determination of microbiome composition differences between controls and patients. FREE: www.jpain.org/article/S152...

Original: Drs. Ziadni, Darnall, Mackey, et al. @stanfordmedicine.bsky.social tested whether a single-session, Zoom-delivered pain relief skills class lowers opioid use in adults with chronic pain receiving long-term opioid therapy. FULL: www.jpain.org/article/S152...

Original: [email protected], O’Brien et al. explored how morally injurious betrayal and wrongdoing, chronic pain, and functional mobility are related in US combat veterans —experiences of betrayal are associated with chronic pain and mobility Full:

Original: Drs. Byiers, Burkitt et al .validated the 7-item Modified Brief Pain Inventory–Proxy for assessing pain interference in people with cerebral palsy: — strong validity, excellent reliability, and sensitivity to treatment effects Full:

Review: Drs. Cherif, Massé-Alarie, et al. @ulaval.ca present a systematic review comparing motor neural network state between individuals with low back pain and pain-free controls, and under experimental low back pain conditions. FULL: www.jpain.org/article/S152...

Review: Drs. Frare, Trevisan, et al. conducted a systematic review and meta-analysis to update and investigate the levels of inflammatory biomarkers in complex regional pain syndrome (CRPS). FULL: www.jpain.org/article/S152...

Featured: Drs. Weissman-Fogel & Treister @Haifaresearch.bsky.social used insights from neuroscience of phantoms and pain phenomena to propose a new, theoretical neural circuit model for phantom limb pain and its chronification. FREE: www.jpain.org/article/S152...

Original: Drs. Bolin, Lagerström & coll. mapped monosynaptic inputs to spinal neuropeptide Y interneurons from spinal, peripheral and supraspinal regions involved in pain, itch and motor regulation FREE: www.jpain.org/article/S152...

Original: Drs. Wang, Liu et al. found that nociceptor-dominant laser paradigms evoke the most consistent temporal summation of pain, supporting their use in mechanistic studies and biomarker development across pain research contexts Full:

Original: In a 7T brain scan study of 44 people, Wake, Dr. Henderson ( @newsroomusyd.bsky.social) et al. found that different brainstem regions were linked to pain relief vs pain increase, suggesting two pain-control circuits in the brain Full:

Original: Drs. Liang, Bai, et al. examined whether a greater number of chronic pain sites is associated with an increased risk of developing type 2 diabetes. – More chronic pain sites were linked to a greater type 2 diabetes risk FREE: www.jpain.org/article/S152...

Original: Drs. Devan, Hale, et al. (@universityofotago.bsky.social) aimed to map content of 13 iSelf-help modules using the Behaviour Change Technique (BCT) Taxonomy and identify and code participant experiences, mapping these to the taxonomy. FREE: www.jpain.org/article/S152...

Original: Drs. Haystead, Scarneo, et al. (@dukehealth.bsky.social) evaluated the therapeutic potential of the selective and potent TAK1 inhibitor, HS-276, to attenuate paclitaxel- and oxaliplatin-induced inflammation and mechanical allodynia. FULL: www.jpain.org/article/S152...

Original: Drs. Cannistra, Kong, et al. analyzed MRI scans of participants with acute musculoskeletal pain (n=160), categorizing them based on those who recovered and those who developed chronic pain later. FULL: www.jpain.org/article/S152...

Original: Drs. Saravanan, Powell-Roach, et al. (@rutgersuniversity.bsky.social) examined associations between perceived healthcare discrimination and pain severity among 89,069 participants from the Registered Tier Dataset. FREE: www.jpain.org/article/S152...

Original: Drs. Ibitoye, Stinson, et al. explored the experiences of adolescents and caregivers using non-pharmacological interventions to manage sickle cell crisis pain at home and in Nigerian hospitals. FREE: www.jpain.org/article/S152...

Original: Drs. @lydiarader.bsky.social, @dangustavson.bsky.social, @torwager.bsky.social, & coll. used mixed-effects models to examine associations between polygenic scores and adolescent self-reported pain presence, intensity, recurrence, and multi-site pain. FULL: www.jpain.org/article/S152...

Original: Drs. Chua, Briggs, et al. (@autnews.bsky.social) aimed to identify and validate youth’s preferences for digital health solutions to support chronic musculoskeletal pain self-care and measure preferences for AI-enabled digital coaches. FREE: www.jpain.org/article/S152...

Original: Drs. Boggero, King, et al. (@cincychildrens.bsky.social) examined associations between Chronic Overlapping Pain Conditions (COPCs) and SPACE symptoms in 47 young adults (ages 18–34) with two or more COPCs. FULL: www.jpain.org/article/S152...

A study across 23 countries led by Drs. Neblett, Luciano & coll. developed the CSI-7, a brief 7-item version of the Central Sensitization Inventory —CSI-7 accurately identifies symptom severity of fibromyalgia with excellent accuracy Full: www.jpain.org/article/S152...

Original: Drs. De Vera, Moayedi et al. ( @utoronto.ca) found that pain intensity, pain unpleasantness, and secondary hyperalgesia show moderate-to-good reliability in a PHP paradigm, but only secondary hyperalgesia area remains stable across sessions FREE:

Featured: Drs. Du, Tang et al. found that SCFA-FFAR2 signaling reduces visceral hypersensitivity in both sexes, but only males rely on FFAR2-dependent suppression of IL-17RA signaling in the anterior cingulate cortex FREE: www.jpain.org/article/S152...

Original: Drs. julieji.bsky.social, Hughes, et al. investigated the impact of mental imagery simulations of threat on endogenous pain modulation in n = 71 healthy participants using a cuff-pressure algometry protocol. FREE: www.jpain.org/article/S152...

Original: Drs. Bembich, Maestro, et al. explored sex-related differences in neonatal nociception, an area that remains relatively understudied despite well-documented disparities in adult pain experience. FULL: www.jpain.org/article/S152...

Original: Dr. Wilson, Meints, et al. examined how chronic pain and gender-related stigma intersect in cisgender women with chronic pelvic pain and their associations with pain and psychosocial factors. FULL: www.jpain.org/article/S152...

Original: Dr. Thomas, @luanacolloca.bsky.social, et al. tested the hypotheses that pain resilience is negatively associated with pain interference, and pain resilience is positively associated with placebo effects via reinforced expectations of analgesia. FULL: www.jpain.org/article/S152...

Original: Drs. Horvat and team at University of Maribor, using electrical pain stimulation, explored neurophysiological mechanisms mediating the influence of romantic partner’s presence on acute pain perceptions. FREE: www.jpain.org/article/S152...

Original: Drs. Yamin, Edwards, et al. examined the extent to which pain catastrophizing contributes to the association between posttraumatic stress symptoms and pain outcomes in patients with chronic low back pain. FULL: www.jpain.org/article/S152...

Original: Drs. Morris,Goodin et al. ( @vanderbilt.edu) showed differential prognostic importance of biopsychosocial factors for high-impact chronic pain incidence, persistence, and recovery using a machine learning approach FREE:

Original: Drs. Guo, Aplin evaluated a soft, metal-free nerve cuff for ionic direct current delivery in healthy and pathological pain models — iDC might represent a potential treatment for chronic pain FREE:

Original: Dr. Badzińska, Bąbel et al. demonstrated that the effectiveness of pain calibration varies significantly across procedures —methodological relevance of calibration in experimental pain research is crucial FREE:

Original: Drs. Lee, Kumar et al. ( @bostonu.bsky.social) found that in knee osteoarthritis, central pain sensitization may ↑ the brain’s cognitive load during walking —People with greater sensitization showed ↑ prefrontal cortex activation and more gait Full:

Original: Arsenault, Drs. Hadjistavropoulos & co. ( @uregina.bsky.social) investigated the psychometric properties and item performance of the Geriatric Pain Measure (GPM-24) when tested with a North American sample of older adults. FREE:

Original: Booth, Dr. Ussher et al. identified key barriers and facilitators—from symptom management and motivation to social and environmental influences—and revealed 4 distinct activity trajectories post-treatment. FREE: www.jpain.org/article/S152...

Original: Drs. Clegg, Tilley et al. ( @uniofbuckingham.bsky.social) showed how dance culture valorizes “pushing through” pain, blurring the line between resilience and harm, and highlights the need for tailored pain interventions. Full:

Original: Drs. Jafarzadeh @lisacarlesso.bsky.social et al. showed that Pain Science Education fostered hope, self-management, and belief that pain can improve, while standard biomedical education increased frustration, fear, and expectations of surgery Full:

Review: A meta-analysis of 48 fMRI studies (2,052 participants) led by Al-Faraj, Valentini et al. found consistent activation of the dorsal anterior insula & mid-cingulate cortex during provoked pain in chronic primary pain disorders Full:

Featured: Drs Rejas-Fernández, Arias-Buría et al. found that adding US-guided percutaneous electrolysis to a manual therapy is more effective for improving pain intensity and disability in subjects with tibialis posterior tendinopathy FREE: www.jpain.org/article/S152...

Thanks to everyone who came by our booth at #USASP2026! 🎉 It was a pleasure to join you all in conversations supporting the Journal’s mission to promote scientific advances that reduce the burden of pain. 👏 We’ll see you next year at @usasp.bsky.social! 🤗

Original: Drs. Strigo, Simmons, @storrisi.bsky.social, @benalter.bsky.social, et al. identified distinct neural phenotypes of pain anticipation in chronic low back pain (cLBP) and examined their clinical and physiological correlates in 43 cLBP patients. FULL:

Original: Drs. Berridge, Hainsworth, et al. (@medicalcollegeofwi.bsky.social) aimed to develop clinical cut-points for the Child Activity Limitations Interview-9 (CALI-9), a measure of pain-related activity limitations in youth with chronic pain. FULL:

Congrats to the #USASP2026 People’s Choice Cover Art Winner: 🎉 Matthew Sapio @mattsapio.bsky.social 👏 See the corresponding article HERE: doi.org/10.1016/j.jp...

Original: Drs. Garcí, Campbell et al. generated a new CRISPR mouse model that targets pain genes specifically in sensory neurons —Knocking down TRPV1 reduced heat sensitivity & capsaicin-evoked pain w/out apoptosis, or motor deficits Full:

Original: Drs. Parisi, Garland &co. (@georgemasonu.bsky.social) found that lower baseline cognitive reappraisal efficacy, indexed by blunted HF-HRV, predicted worse response to psychological treatment for adults with opioid-treated chronic low back pain Full:

Congrats to the Red Pen Challenge winners at #USASP2026! 🎉 🥇 Jen Stinson 🥈 Selena Frantz 🥉 Jeffrey Boon Honorable mention: Jonathan Mercado-Reyes All scored 8/8 — an incredible showing! 👏 @usasp.bsky.social

Original: Drs. Trial, Kolber et al. found that CGRP in the amygdala modulates cold, but not mechanical, sensitivity in neuropathic pain —its effects depend on hemisphere, injury site, and pain type Full:

Original: Drs. Rogers, Edmond, et al. (VA CT, @yaleschoolofmed.bsky.social) aimed to identify indicators of and work toward a consensus definition of a high-functioning pain management team via a modified Delphi study using a panel of 47 pain management experts. FULL: