I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

1/ 97% of cortical PNNs are on PV interneurons. But PNN-positive and PNN-negative PV cells don't split into two groups — they sit at different ends of a transcriptional continuum of fast-spiking specialization. New preprint 🧵

I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n www.nature.com/articles/s41...

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...

✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡 www.biorxiv.org/content/10.1... 1/13 🧵

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/...

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...

We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Congrats to Marta, Stephen and the whole team!

New preprint out in eLife! Neurons in medical entorhinal cortex (MEC) develop responses to visual cues and reward as mice learn a visual Go/NoGo task. elifesciences.org/reviewed-pre...

Like every year, our lab plans to attend the @sfn.org meeting in the US. But is it safe to go? This scientist was sent back (as confirmed by @lemonde.fr, no less). Other visitors were recently detained by ICE goons for days. It feels risky. See y'all at FENS in Barcelona? www.fens.org

Sadly, it’s time to revive this 2017 TIME cover.

Thalamic opioids from POMC satiety neurons switch on sugar appetite www.science.org/doi/10.1126/... - or why we crave dessert, even when we're full! 🍰🍨

delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab www.nature.com/articles/s41...

1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social Video: www.youtube.com/watch?v=yw_4... Paper: www.nature.com/articles/s41...

A little challenge for neuro/cog sci (/psych/comp-sci/bio/philosophy!) blueys: How would you define "cognition"?

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: ✨exceptional, brightness ✨phototability ✨and optogenetic compatability. Check out our new preprint: www.biorxiv.org/content/10.1...

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

Together with some friends we built an optical Brain Machine Interface to see if cortical activity (PPC) can control behaviour in real time, without animals having to learn to use it. Here's what happened: www.biorxiv.org/content/10.1...

In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! www.biorxiv.org/content/10.1...