🧠🪰 The adult Drosophila brain connectome now gives us a complete wiring diagram of ~140k neurons. But a wiring diagram alone isn’t understanding. How is this massive network organized? Our paper tackles that question by mapping community structure across the entire fly brain. 1/

🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com 🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals. www.nature.com/articles/s41... Join us: penglab.de

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

Extremely happy to share our lab’s first paper now published in @NatureSMB! We determined the cryo-EM structures of GluA4, both alone and in complex with TARP2, capturing the receptor in different functional states.

Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.

Are you passionate about advancing cutting-edge imaging technologies, and combine expansion microscopy with the power of AI@HHMI to unlock new biological discoveries? If you’re ready for a creative,and impactful journey, we’d love for you to apply! hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...

If you are interested in a position working on the coolest new developments in connectomics - take a serious look at this. Incredible technology development opportunity, working with a super nice scientist! Check out the paper here if you haven’t seen it yet: www.nature.com/articles/s41...

Really beautiful hippocampal connectomics from @zhihaozheng.bsky.social et al. Such high quality data shows many interesting circuit wiring surprises - an incredible resource to digest! Great also to see the parallels with our physiology work on neuronal heterogeneity www.biorxiv.org/content/10.1...

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social ! With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding. (1/13)

If you are using IVA Cloning for your plasmid work... there is a cool new tool to make primer design very easy: ivaprime.com The explanation paper is here: academic.oup.com/nar/advance-...

Incredibly impressive and powerful new method - connectomics with light microscopy! Congrats @mojtabart.bsky.social, Hans Danzl and team @istaresearch.bsky.social ! It works incredibly well - we will keep using this magic, and recommend you do too!

Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness: “The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”

The Neural Mechanisms of Cognitive Function meeting in beautiful #Pipa has sadly come to an end, but this meeting has given me new faith that really fascinating and innovative science is fully compatible with a kind, considerate, and supportive atmosphere! #BeNiceAndEnjoyYourScience

Striking insights into the information content of hippocampal subpopulations! A really stunning example of how understanding discrete cell types brings coherence and clarity to complex neuronal activity. Congrats to all

Beautiful and thorough dissection of neuronal heterogeneity! Individual cells matter.

The new issue is out!! 👉 cell.com/cell/current Featuring the engineering of source-sink relations to⁠ create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis! 📷: Jake Watson⁠

Possibly as exciting as the science - our view of.. ‘exploring brain function across species’ made the cover of Cell @cellpress.bsky.social Arranged with local ingredients while walking on Gimsøy, Norway! www.cell.com/cell/current (and paper below)

My new year's resolution was to work through the pile of almost-finished papers so... #PrePrintAlert #NeuroSkyence. This is an update to one we put out late 2021, which got delayed with Lilya (lead author) going on maternity leave (yay, lab baby! 🥰). A brief 🧵 1/ www.biorxiv.org/content/10.1...

More human neurophysiology out today from the Geiger Lab. *Analogue* neuronal output modifies synapses for consolidation during sleep states. With such beautiful data and interpretation it’s easy to forget that the recordings are heroically tough. Fantastic research from @fxmittermaier.bsky.social

Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few

Find the AAV plasmid you wanted in our repository...but not the viral prep? We heard you, and we're thrilled to announce that our viral vector service is expanding to include a packaged on request option! Check out our blog post to learn more: blog.addgene.org/add...

Very interesting technical paper showing that expression of AAVs is particulary strong in CA2 (and also why this is the case): www.biorxiv.org/content/10.1... We have also made this observation (off-target effect when targeting CA1), so it's nice to see this confirmed (and explained!).

The Nordic #neuroscience societies welcome you all to the FENS Regional Meeting in Oslo next year - the first time ever in a Nordic country! The CALL FOR SYMPOSIA is still open until 30 November. Submit now! frm2025oslo.no #FRM2025 #brain #FENS @pirtahotulainen.bsky.social @olekiehn.bsky.social

Recording synaptic minis (mEPSCs)? We have a new paper trying to better understand how recorded datasets match synaptic changes. In short, they don't.. More info below, and the preprint here: biorxiv.org/content/10.1101/2024.10.26.620084v1