A lifehack for turning "non-significant" results into pure gold? (ICYMI) statsepi.substack.com/p/one-simple...

November means it's time to start auditioning cheeses to see which ones can earn their spot on our Christmas dinner table... 🤤

Today for #FluorescenceFriday I’m sharing a 👻Halloween-themed🎃 neural crest explant “web of cells” from Julia Godinez, a 4th year @ucdavis.bsky.social graduate student in the lab. She is studying mechanisms driving conserved and divergent cranial neural crest migration and differentiation. #DevBio

*The uninvited guest* (sound on this time!) Third week of observing scary things under the microscope: watching #SARSCoV2🟣 positive cells arrive in the brain. Note it's still inside a blood vessel and being checked by astrocytes🟢and microglia🔵. What happens next? 😨 #FluorescenceFriday

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

Another #FluorescenceFriday image here, from an ongoing project studying circuitry of the retrosplenial cortex. Here we are using rabies to map the inputs specifically to the deep pyramidal cells (L5). Cyan shows the deep cells and magenta shows their presynaptic partners. #NeuroSkyence

𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻?? Astrocytes in the regulation of fear memories! www.nature.com/articles/s41... #neuroskyence h/t @claeneuro.bsky.social

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

Excitatory input from #PrefrontalCortex to #hippocampus pyramidal cells is believed to be mediated through the thalamic nucleus reuniens. @mickcraig.bsky.social &co show in rodents that this brain pathway is unexpectedly minor, contrary to assumptions in the field @plosbiology.org 🧪 plos.io/48u6mle

I'll say it: I think its rly annoying and frankly amateurish that writers are constantly told their villains must be understandable or have sympathetic motivation to be interesting or realistic when all our big villains irl are in fact rich, stupid, selfish, trickster dillweeds and always have been

Delighted that our main #TeamReuniens paper is finally out in @plosbiology.org. Been a long time in the making, congratulations to Lilya and all the team. A thread to follow soon, after I've had some sleep... #NeuroSkyence journals.plos.org/plosbiology/...

Did a slightly early Thanksgiving meal today and my pumpkin pie set! I take a somewhat freestyle approach in the kitchen so have a patchy track record with pumpkin pie, but I actually read a recipe and measured a little today. Enjoy tomorrow for those to celebrate! 🍁🇨🇦

No comment on what THIS company is doing because (*shudder*), but if you want to follow REAL scientists on this look at groups like: www.ucdavis.edu/news/brain-c... publicly 👏 funded 👏 research 👏 changing 👏 lives 👏

I finally made a lab website, a mere 9 years after starting... oops. It's still a bit rudimentary but it'll do for now... craiglab.org

Not going to lie, this is spot on and frankly, yeah, this IS how I feel and if I wasn't clear, placing this because she did it better than I would have and to be certain, in less time. 😜 If this is #cringe, then cringe away because I'm not.

Are we still doing #FluorescenceFriday? #NeuroSkyence

For Starmer and Labour the point is to beat Reform in elections. Maybe this will work, to that end. But for the public and the nation, the important thing is to defeat the fascism and its racism. And this approach will achieve the very opposite

Fully funded #FindAPhD! We'll be studying neurobiology of motivation in mice hunting crickets, using a combination of genetic manipulations, behaviour and in vivo ephys. Co-suprvised by the amazing @agonru.bsky.social and Gareth Arnott at QUB. #Neuroskyence Pls share www.gla.ac.uk/postgraduate...

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...

This is how you can test selected comparisons in #tidyplots 0.3.1 📋 #rstats #dataviz #phd

Do you ever sign a peer review? I reviewed a paper last night and the journal have the option to sign the review. I almost did but then decided against it. #NeuroSkyence

I guess mathematically speaking you can’t count zeros

I don't understand #UCU at the moment. Am I happy having had several years of continuous pay cuts with very below-inflation pay rises? Absolutely not. But UK higher education is in crisis. Do I want to go on strike to force pay rises that may result in my colleagues losing their jobs? Also: no.🤦‍♂️

I'm sure there probably have been bigger acts of urban vandalism than running a major motorway through the heart of a city, but I can't think of right now. #Glasgow

Yeah, deleted this a long time ago...

IMPORTANT 🧵 We've been seeing how RFK Jr & anti-vax lobby has been steadily and effectively reducing access to vaccines in the US. But it could happen in UK too. It's a threat worth considering given Malhotra's speech at Reform conf & big overlap between anti-vax and RW populsim. Read on! 1/11

It's utterly shameful that it's only "in doubt"...

US Ambassador doesn't like #ElbowsUp as he thinks it's anti-American, but it's fine for the US president to speculate about annexing Canada? This idiot needs to get a fucking grip.

There’s a real generational divide between Labour MPs leaking to the Guardian and Labour MPs leaking to the Huffington Post

Small victories #SpellingBee

I want to start a new global movement: Meetless Monday - we encourages people to reduce their meeting activity by one day each week for personal health and the planet's well-being.

Well said.

The age of enshittenment.

Not that it comes as much of a surprise to many of us, but it's worth emphasizing once again - the 👏 brain 👏 uses 👏 distributed 👏 coding 👏. 😁 Two new papers from the #IBL looking at brain-wide activity: www.nature.com/articles/s41... www.nature.com/articles/s41... #neuroscience 🧪

There's a very cool Buzsaki #neuroskyence paper out in Science this week, looking at hippocampal spatial information encoding by multiple interneuron subtypes in parallel. The brilliant @agonru.bsky.social and I wrote a wee perspective to go alongside it: www.science.org/doi/10.1126/...

Couldn't sleep as I had a full and very exciting day of #neuroskyence and was buzzing. Had to get up and have a dram and some shit TV on the internet to decompress. Been a while since I've had such a fun science day. Good times.

Yesterday my wife, the awesome @dominiquechaput.bsky.social gave evidence at the Scottish Hospitals Inquiry. She gave a absolute masterclass in scientific communication, clearly defining complex subjects and interpreting within the limits of that the data. www.youtube.com/watch?v=3lH3...

But the US is not fascist! 49.8% of the voters can’t be wrong! He’s no Nazi! [& so the defence goes]. In 1937 Hitler decided that museums should only exhibit state [his] approved art. It was called Entartete Kunst (Degenerate Art). 88y later America’s führer is introducing it again. Not good.

I'm feeling a little Canadian today. Their slogan is a bit more socially acceptable than “fuck Trump”, so suitable to wear while teaching… 😏

This little bit of warmth has made my news feed a much nicer place today...

IMO, when you ask for people's time for something, the least you can do is send the calendar invite with all the details and save them that time and mental energy. I know, this shouldn't be a novel concept.

More than a week later, my manuscript revision remains unsubmitted as the journal’s technical support team try to work out what went wrong… 🫣 #NeuroSkyence

I think I broke the journal submission system... 🫣 #NeuroSkyence

We have updated our nucleus reuniens paper: now with added data from rat (courtesy of Zaf Bashir's lab in Bristol). They also failed to evoke a synaptic response in CA1 pyramidal cells when activating reuniens axons, in either dCA1 or vCA1. #NeuroSkyence www.biorxiv.org/content/10.1...

We have updated our nucleus reuniens paper: now with added data from rat (courtesy of Zaf Bashir's lab in Bristol). They also failed to evoke a synaptic response in CA1 pyramidal cells when activating reuniens axons, in either dCA1 or vCA1. www.biorxiv.org/content/10.1...

Airport security is always at its most efficient when you're not in a hurry. 1h40 to kill now... 🙄. Oh well, Bristol here I come!

Finally got around to reading the Salmon of Doubt. Dragged my heels for the best part of 2 decades as I wasn't quite ready to say goodbye to Douglas Adams... Here are his thoughts on England 🤣

This month’s "Launch" newsletter features an essay by Sheena Josselyn on the importance of reading (but not too much), Q&As with @agonru.bsky.social and @drewkesner.bsky.social about their new labs, the latest job openings and more. Subscribe to receive the newsletter each month: bit.ly/4luI2mJ

Over a decade ago I used to edit a magazine called One in Four. The tagline was 'written by people with mental health difficulties, for people with mental health difficulties'. We did it for 7 years. It was born out of my live of reading about the mundane stuff of everyday life from specific angles