Happy to see this out w/ @epsteinstatgen.bsky.social and @davecutler.bsky.social (paper: doi.org/10.1093/bioi...)! We tackled the problem of identifying dysregulated pathways (i.e. differentially co-expressed) in gene expression studies. We show that differential co-expression arises ...

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs. Paper: www.nature.com/articles/s43...

RIP, Prince of Darkness. Arguably in the Top 5 of most influential artists of my lifetime

Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!

Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm! Submission deadline is June 8th, conference July 6-11th.

Multiple Postdoc Positions available in Epidemiology, Biostatistics, or Statistical Genetics (deadline April 15) Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark! #Postdoc #Epidemiology #StatisticalGenetics #Biostatistics 👉 international.au.dk/about/profil...

Happy Chrismukkah to all the delightful half-half situations (like me)

Accurate.

For those working in pathway and co-expression analysis, check out Andy’s recent preprint describing a more powerful and flexible framework for such studies!

We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky

I'm developing a pipeline to call CHIP mutations in UK Biobank using the DNA Nexus RAP that is fast/cheap/reproducible. Initial results are promising; calls looks reasonable and cost to do this across all of UKB is likely < 500$. Feel free to DM if of interest.

Finally a VP who’s had to design a syllabus!

Excited to share our method LIT; a kernel approach to map genetic variants with interaction effects on multiple phenotypes in biobanks. R package implementing the method available on CRAN. Kudos to Andy Bass for leading this work! genomemedicine.biomedcentral.com/articles/10....

CHARLIE BROWN: Can I kick it? LUCY: Yes, you can! CHARLIE BROWN: Can I *kick* it? LUCY: Yes, you can! CHARLIE BROWN: Can I _kick_ it. LUCY: Yes, you can! CHARLIE BROWN: {running toward ball} Well, I’m gone! LUCY: {pulling the ball away} Gone!

Please be sure to check you kid's candy this year. I just found another project I have no time for in a Reese's cup

Preprint is up now www.biorxiv.org/content/10.1...

Trying to be better with sharing work on here 😅 Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠

👋 Hi genetics/statgen/gen-epi trainees! 🧬 🧪 If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!

Pep and jazz band member Latin Club member who also took Ancient Greek Listened to Rush 24/7. I checked all the boxes

bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...

Introducing some cool work by @ajbass.bsky.social in my lab for detecting genetic variants with interactive effects on phenotypes of interest in biobanks leveraging pleiotropy. Hope you find it interesting!

Just curious; what is the longest wait time anyone has experienced for a desk rejection?

GWAS of antimullerian hormone (AMH) levels in the Finnish population. One of the hits is CHEK2 driven by a loss of function variant that is 4x enriched in Finland. Pujol-Gualdo et al. medRxiv www.medrxiv.org/content/10.1...

My latest cure for writer’s block

@danirabaiotti.bsky.social : could I please be added to the science feed? Thanks so much!

What cheat codes unlock the secret character

Via Mark Reid on Mastodon, a major breakthrough in Computer Science. https://mastodon.social/@mdreid/110788590371496537

Hi! I have a PhD in Biostatistics and work on developing/applying statistical tools to improve understanding of genetic basis of various complex traits (current focus: Alzheimer’s disease and breast cancer). Thx to marine conservationist (and brainy cousin) @katieocean.bsky.social for the invite!