Nature Reviews Nephrology (@natrevneph.nature.com)

Two decades of nephrology research: progress and future challenges Nature Reviews Nephrology, Published online: 19 September 2025; doi:10.1038/s41581-025-00996-5Since publication of the first issue of Nature Reviews Nephrology 20 years ago, advances across various subspecialities of nephrology have provided insights into disease processes and led to the development of new therapeutics for people with kidney disease. However, despite this progress, many kidney diseases remain untreatable, the costs of kidney disease care are immense, and vast inequities persist in disease burden and access to care. In this Viewpoint, we ask experts from several key subspecialties of nephrology to reflect on progress made over the past 20 years, remaining challenges and the steps needed to move the field forward. https://www.nature.com/articles/s41581-025-00996-5?utm_source=bluesky&utm_medium=social&utm_campaign=nrneph