Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4 - Journal of Biological Chemistry www.jbc.org/article/S002...

Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+ www.cell.com/molecular-ce...