#Immunology Intelectin-2 is a broad-spectrum antimicrobial lectin It binds glycans on mammalian cells (inducing mucin cross-linking) and on bacterial cells (leading to antibacterial activity) @laurakiessling.bsky.social @kiesslinglab.bsky.social

⏰ Submit short talk abstracts and/or scholarship apps by Feb 4 at 11:59 PM for the Symposium on Tumor Microenvironment. 🎤 Speaker preview: youtu.be/lyK8XkYC8cI 🔗 Apply: keysym.us/KSTumorMicro26 @coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social #KSTumorMicro26

Fun collaboration with @thexavierlab.bsky.social and Ribbeck groups to figure out how this human lectin plays multiple roles in controlling the #microbiome: stabilizing the mucus barrier and reducing bacteria that breach it. news.mit.edu/2026/protein... #glycotime

This meeting should be very fun as the program is quite diverse. (Even chemical biologists).

Join us for the 2025 Welch Conference on Chemical Research, “New Horizons in Drug Discovery,” Oct. 27-28 in-person or virtually. The event is completely free! Find more information here: welch1.org/conference/c...

Don’t miss Pamela Bjorkman’s keynote address at the 2025 Welch Conference about the need to combat future SARS-CoV-2 variants and new spillovers of SARS-like betacoronaviruses. Join in-person or virtually here: welch1.org/conference/r...

Looking forward to a great #chembio program hosted by @thewelchfoundation.bsky.social and organized by Kevan Shokat welch1.org/conference/c.... Great coincidence that Welch honorees are Stuart Schreiber and Pete Schultz.

Amazing news that the 5th Virtual @chembiotalks.bsky.social attracted 450 participants from 50 countries. If you are as excited as we are, already mark next year's date (29th of September, 2026) in your calendars and make sure to suggest your favorite speakers! #ChemSky #ChemBio #DrugDiscovery

Come join us at @stanford-chemh.bsky.social! I feel incredibly lucky to have launched my career here -- it is a fantastic place to do bold interdisciplinary science surrounded by creative & supportive colleagues. Applications are due 10/15/2025 -- DM me if you have questions about the search!

We are hiring! If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland! More information on www.epfl.ch/labs/gr-schu...

Looking forward to talking today about some new ways of looking at what human lectins do. #FallACS2025

We are so grateful for resources to help us test key ideas about glycans and #Alzheimers disease. #glycotime🧪

To overcome challenges that #neurodegenerative diseases pose, MIT’s Aging Brain Initiative has awarded seed grants for 5 innovative research projects. Congrats to Drs. Joseph Coughlin, Giovanni Traverso, Pattie Maes, Bin Zhang, @laurakiessling.bsky.social & @eboyden3.bsky.social ! bit.ly/4mVasaV

Opportunity in fragment-based design at Lilly (job available in 4 locations | UK: Bracknell | USA: Boston MA, Louisville CO, San Francisco CA) ref: R-86733 #FBD #FBDD #FBLD #CADD #CompChem #cheminformatics #ChemJobs #UKChemJobs #chemsky 🧪 careers.lilly.com/us/en/job/R-...

Brief victory celebration and NEW ASSIGNMENT More than 27,000 comments posted regarding Schedule F implementation! 1/n

Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Lead author @ssmelyansky.bsky.social spearheaded a strategy to label a single sulfur-containing glycan called ManLAM on the cell envelope of the bacteria that cause #TB. news.mit.edu/2025/new-mol... or here: www.pnas.org/doi/10.1073/... 🧪 #glycotime @mitchemistry.bsky.social

We are so excited to see the cool science that will come out of your group #chemsky

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

🙏 We need your help 🙏 The government continues to cancel grants at both NIH and NSF to censor science it doesn't like. We're tracking terminations to organize and advocate. Please report your terminated grants: NIH: forms.gle/J2znQ7y7YpeP... NSF: airtable.com/appGKlSVeXni... w/ @noamross.net

We’re thrilled to feature an incredible lineup of plenary speakers at #Glyco27! These experts will share cutting-edge insights and the latest advancements in glycomics across areas of health, including immunology, neuroscience and more! Register today: glyco27.org/en/begin @glycotime.bsky.social

These kinds of cuts are taking place when #TB rates are rising, including in the US. They dovetail with USAID cuts to #TB programs.

Job opportunity in SF to work at a small startup with the first PhD graduate of the Lieberman Lab!

A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB

Thanks to Ratmir Derda we have an articulate reply to: www.science.org/doi/10.1126/... putting glycans back into the picture! @laurakiessling.bsky.social @anneimb.bsky.social @carolynbertozzi.bskyverified.social @molinarotony.bsky.social @dbojar.bsky.social @siglecdude.bsky.social

This is really beautiful research showing how the glycocalyx changes with aging and its impact on the blood-brain barrier.

For the Idaho Statesman 🥔, Professor Melanie Samuel explains how science funding drives cures for diseases like Alzheimer’s and cancer— and the devastating impact of mass firings in Health & Human Services. Happy Homecoming 🧪🧬🔬🏠 www.idahostatesman.com/opinion/read...

Catherine Grimes (University of Delaware) Laura Kiessling (MIT) @laurakiessling.bsky.social Apply now on the GRC website! #glycotime

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

If you would like to see how much economic activity and grants and how many people are employed through NIH in your state, just use this handy website. And then contact your Congressional Rep and tell them to prioritize NIH. www.unitedformedicalresearch.org/nih-in-your-...

I am confident that scientific societies will play an unusually important role in the coming years. If you are a microbiologist of any kind, please consider joining @asm.org if you haven't already. There are many ways to get involved, including advocacy. To learn more: asm.org/About-ASM/Vo...

🚨 Registration is now open! 🚨 Join us for 'Seeing is believing: imaging the molecular processes of life', where cutting-edge imaging methods meet groundbreaking biological discoveries. 🌟#EESImaging 📅 8 – 11 October 2025 📜 Submit your abstract by 2 July! 👉 https://s.embl.org/ees25-09-bl

6 more weeks to apply ! Become our new colleague at the Cell Biology Dpt and join the growing group of junior teams of @i2bcparissaclay.bsky.social shaping the scientific environment of the institute. Apply if you are looking for a place to start a lab or forward to any potential candidates.

Please consider making a contribution to this special fund that will be used by Caltech and JPL to directly support affected individuals and their families greatly impacted by this week's devastating fires in Southern California. giving.caltech.edu/areas-to-sup...

If you are interested in 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆-𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴, definitely consider the #ABPP2025 conference on March 30th to April 2nd, 2025, at The Francis Crick Institute. Registration deadlines have been updated. www.linkedin.com/posts/14th-i...

Here is a chembio starter pack I made recently: bsky.app/profile/ache...

Thinking about the cool #chemistry all those understudied bacterial species do

Just listened to a fantastic talk on harnessing evolution to do new #chemistry by @francesarnold.bsky.social at the Bowei Research Conference in Taiwan. Loved her advice: “Nature does not care about your calculations.”

Memorial Tribute to Alex Pines on January 13, 11 am EST / 5 pm CET, online, zoom information to be posted at ismar.org on January 12, please contact Rob Tycko if you would like to contribute, for more information -> listes.services.cnrs.fr/wws/arc/nmr/... posted 12/26/2024 #NMRchat 🧲

Really enjoyed the opportunity to have the @kiesslinglab.bsky.social collaborate with the Imperiali Group on exploring human lectin interactions with glycans. #glycotime Some initial findings are here: www.biorxiv.org/content/10.1...

Helpful time-saving advice

Happy Saturday. If you're working on your NIH specific Aims for a February submission, don't include a figure. grants.nih.gov/grants-proce....

HAPPY HOLIDAYS and EXCITING NEWS!!! We are offering two conference scholarships for 2025 to early career scientists! One for the Keystone Proximity-Based Therapeutics Conference and one to Frankfurt Conference on Quality Control in Life Processes. Application and details: forms.gle/aP4n7HTujetb...

@kiesslinglab.bsky.social is fortunate to have Gerard Porter as a member of our team @mitchemistry.bsky.social. I loved this article highlighting how the Caribbean Science Foundation is facilitating the education of talented researchers to promote innovation www.eecs.mit.edu/a-launching-...

This topic (and conclusion) is one that I have been teaching about for awhile in my organic chemistry class. The difference is that it was not within reach 10-15 years ago. This analysis is valuable for teaching. #chemsky 🧪

Cool work from the Traverso group @mitofficial.bsky.social news.mit.edu/2024/bioinsp...

Valerie Lensch of @kiesslinglab.bsky.social and the Johnson group reviewed different glycan-based strategies for eliciting an immune response: academic.oup.com/glycob/artic... #glycotime

When I went to the @yaleuniversity.bsky.social #chembio retreat, I got this cool #glycotime shirt. I showed it to Yale alum @ssmelyansky.bsky.social. The response: “That’s so cool that they used the B. subtilis glycocalyx!” Wow. People in @kiesslinglab.bsky.social recognize cells via their glycans.

If you are interested or working in #structuralbiology, as you see any protein (yes, *any*), you should be thinking: is it glycosylated? The answer is likely to be yes! You can predict N-glycosylation sites and rebuild all types of glycans with ReGlyco glycoshape.org 😌 Check out the example ⬇️ 1/2