Our latest effort to translate genetic risk variants to disease mechanisms revealed that the R448G missense mutation in nuclear receptor coregulator NRIP1 promotes tissue inflammation via inefficient repression of a retinoic acid-mediated T cell gut-homing program. www.pnas.org/doi/10.1073/...

ANKRD55 is associated with risk for multiple autoimmune diseases, but without a clear mechanism. In a new @jem.org study, we show that ANKRD55 promotes differentiation of inflammatory T cells via mitochondrial regulation, suggesting a new target for autoimmunity: rupress.org/jem/article-...

Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/... #Autoimmunity

NEW in PNAS: Our collaboration w/ the Seyedsayamdost lab, from Princeton University's Dept of Chem, revealed that indole-derived compounds produced by IBD-associated Campylobacter concisus are key modulators of inflammation www.pnas.org/doi/10.1073/... @broadinstitute.org @mgbresearch.bsky.social

For a great example of complex science presented clearly and compellingly, check out this Base by Base PaperCast episode! It covers a recent @finngen.bsky.social n study showing protective effects of CFHR5 loss-of-function against age-related macular degeneration. Links below 👇

Online now a multicenter Crohn's Disease study of South Asian patients that explores environmental impacts on #CD, linking geography and immigrant status with disease presentation and serologic markers. linkinghub.elsevier.com/retrieve/pii... #crohnsdisease

Check out our recent work with John Rioux and the iGenoMed Consortium! Serum proteomic and metabolomic profiling in #IBD patients initiating vedolizumab identified pro-inflammatory analytes associated with treatment response. onlinelibrary.wiley.com/doi/10.1111/...

In our latest collab w/the Clardy Lab @HarvardMed to mine microbial metabolites for immunomodulators, we identified how Eggerthella lent—one of the most studied & least understood members of the human gut microbiome—upregulates inflammatory responses in a cell- & antigen- independent fashion. (1/2)

Very excited to share our latest work in @NatureGenet with the Smillie lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation...(cont.) www.nature.com/articles/s41...

(1/6) Our latest paper in ‪@cp-cellhostmicrobe.bsky.social‬ shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway. www.cell.com/cell-host-mi...

Bacterial sphingolipids delivered by outer membrane vesicles persist within mammalian immune cells and promote IL-10 secretion via the mevalonate pathway www.cell.com/cell-host-mi... @thexavierlab.bsky.social @cp-cellhostmicrobe.bsky.social

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

Out now in @Science! We and the @kuchroolab.bsky.social described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity www.science.org/doi/10.1126/...

Dedicating our first Bluesky post to our junior scientists moving on to next exciting steps of their career! First on our list: huge congrats to Joanna Atwater, one of our amazing clinical research coordinators, on her next big step - pursuing a DMD at @tufts.edu Tufts School of Dental Medicine!