Chatrin
@chatrin-c.bsky.social
📤 30
đź“Ą 53
đź“ť 1
A scientist working on ubiquitination and ADP-ribosylation.
reposted by
Chatrin
Nature Structural & Molecular Biology
15 days ago
ICYMI: New online: The rise of ADP-ribose–ubiquitin
loading . . .
The rise of ADP-ribose–ubiquitin
Nature Structural & Molecular Biology, Published online: 08 September 2025; doi:10.1038/s41594-025-01651-0Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.
https://go.nature.com/47zkrNI
0
3
1
Read our comment on the rise of ADP-ribose-Ubiquitin hybrid modification. It's been fun to see it grows :)
add a skeleton here at some point
16 days ago
0
6
1
reposted by
Chatrin
Andrii Gorelik
3 months ago
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max,
@chatrin-c.bsky.social
and Rishov. Happy to have a small contribution in this story
loading . . .
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
https://www.nature.com/articles/s41467-025-61111-7
0
16
5
you reached the end!!
feeds!
log in
