Chatrin
@chatrin-c.bsky.social
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A scientist working on ubiquitination and ADP-ribosylation.
reposted by
Chatrin
Nature Structural & Molecular Biology
10 months ago
ICYMI: New online: The rise of ADP-ribose–ubiquitin
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The rise of ADP-ribose–ubiquitin
Nature Structural & Molecular Biology, Published online: 08 September 2025; doi:10.1038/s41594-025-01651-0Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.
https://go.nature.com/47zkrNI
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Read our comment on the rise of ADP-ribose-Ubiquitin hybrid modification. It's been fun to see it grows :)
add a skeleton here at some point
10 months ago
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reposted by
Chatrin
Andrii Gorelik
about 1 year ago
An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max,
@chatrin-c.bsky.social
and Rishov. Happy to have a small contribution in this story
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
https://www.nature.com/articles/s41467-025-61111-7
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